Module 5: Unit E

Question 1

What is the difference between Suboxone and Subutex? Who is Subutex indicated for?

Answer 1

The drug Subutex is buprenorphine alone. It can be used as maintenance therapy or as a taper to facilitate detoxification.

Suboxone is a combination of buprenorphine and naloxone. The addition of this antagonist is to discourage IV drug use. If Suboxone is taken IV, withdrawal will occur.

Question 2

What is MAT?

Answer 2

Medicated assisted therapy

Question 3

What treatment drugs in the module prolong Qt interval?

Answer 3

Methadone, cocaine, buprenorphine (subutex)

Question 4

Opioid antagonist example

Answer 4

Narcan

Question 5

Indication for Narcan

Answer 5

Opioid overdose

Question 6

MOA Narcan

Answer 6

Opioid antagonist

block or reverse opioids by competitively occupying the receptor site that the narcotic occupied.

Question 7

Safety/D2D/etc for Narcan

Answer 7

Reverses the effects of respiratory depression, hypotension, and sedation.

Due to half-life, it is possible for a person who was revived to relapse back into respiratory depression after 30 minutes.

Question 8

MAT Opioid example

Answer 8

Methadone

Question 9

Indication methadone

Answer 9

long-term management of opioid addiction.

Question 10

Safety methadone

Answer 10

The use of methadone in treating drug addiction is restricted to Substance Abuse Mental Health Service Administration (SAMHSA) and state-certified programs.

Prolongs QT

Question 11

MAT

Opioids Partial agonist example

Answer 11

Buprenorphine (Subutex)

Question 12

Subutex indication

Answer 12

Opioid use disorder

Question 13

MOA subutex

Answer 13

Partial agonist at mu-opioid receptors and a full antagonist at kappa receptors

Question 14

Subutex safety

Answer 14

When used in addiction treatment, do not begin the partial agonist until withdrawal from the opioid has already started.

Question 15

MAT
Mixed
example

Answer 15

Buprenorphine and Naloxone (Suboxone)

Question 16

Indication Naltrexone or Buprenorphine

Answer 16

Opioid use disorder is used to discourage the return to the use of opioids after detoxification.

Used in the treatment of alcohol abuse and off-label for weight loss.

Question 17

Safety opioid antagonist Naltrexone

Answer 17

Naltrexone is contraindicated in patients who are active narcotic users, have severe liver disease, and/or have moderate to severe renal disease.

Question 18

BBW Naltrexone

Answer 18

hepatocellular injury may occur with excessive doses

Question 19

Medication for Maintenance of alcohol abstinence

Answer 19

Acamprosate calcium (Campral)

Question 20

Indication for Acamprosate calcium (campral)

Answer 20

maintenance of abstinence from alcohol by reducing alcohol cravings

Question 21

MOA Acamprosate calcium (Campral)

Answer 21

possibly by blocking glutaminergic N-methyl-D-aspartate receptors, while gamma-aminobutyric acid type A receptors are activated.

Question 22

Safety Campral

Answer 22

Only reduces cravings.

Contraindicated in patients with severe renal disease. Use caution when prescribing for patients with depression and the elderly.

Question 23

is used to create alcohol aversion

Answer 23

Disulfiram (Antabuse)

Question 24

MOA Antabuse

Answer 24

a potent alcohol dehydrogenase inhibitor

Question 25

Safety antabuse

Answer 25

The symptoms can range from flushing, confusion, and vomiting to tachycardia, dyspnea, and syncope. Reactions can even be fatal. The symptoms and intensity are related to the amount of alcohol ingested, the dose of disulfiram, and the time elapsed between medication and alcohol consumption.

Does not eliminate or diminish withdrawal symptoms. This drug is contraindicated for patients with psychosis, severe myocardial disease, or recently used metronidazole. This drug is contraindicated in the concomitant use of alcohol.