Module 5 Lesson 2

Question 1

Flat or biconvex discs of unit dosage forms containing one or more active ingredients, compressed along with necessary aditives

Answer 1

tablet

Question 2

Ingredients used in tablet formulations

Answer 2

API & excipients

Question 3

Excipients properties

Answer 3

-Must be non-toxic and physiologically inert
- must be free from microbial contamination
- do not alter bioavailability of drug

Question 4

excipients

Answer 4

-Binder and adhesives
-Disintegrants
-glidants
-antiadherants
-lubricants

Question 5

These Materials are added either dry or in wet form to form granuels

Answer 5

binders and adhesives

Question 6

Example of binders and adhesives

Answer 6

Acacia, tragacanth, cellulose derivatives, starch paste,hydroxy propyl methyl cellulose

Question 7

-to promote breakup of the tablets

Answer 7

disintegrants

Question 8

To promote rapid release of the drug

Answer 8

disntegrants

Question 9

Reducing friction between particles

Answer 9

glidants

Question 10

To improve the flow properties of the granulations

Answer 10

glidants

Question 11

Prevent adherence of the granules to the punch faces and dies

Answer 11

antiadherants

Question 12

Examples of antiadherants

Answer 12

Talc, corn starch

Question 13

To redue the friction during tablet ejection

Answer 13

lubricants

Question 14

Examples of lubricants

Answer 14

Stearic acid, magnesium stearate, talc, PEG, surfactants

Question 15

Organoleptic agents

Answer 15

Sweetening agents, coloring agents, flavoring agents

Question 16

Sugar, mannitol, saccharine

Answer 16

Sweetening agents

Question 17

500 times seeter than sucrose

Answer 17

Saccharine (artificial)

Question 18

Use of colors and dyes in a tablet

Answer 18

Coloring agents

Question 19

Purpose of coloring agents

Answer 19

Mask of off color drugs
Product identification
Production of more elegant product

Question 20

does particle size of granulation affect the average tablet wright, weight variation, disintegration time, friability, granule flow ability

y

Answer 20

yes

Question 21

Coloring agents

Answer 21

FD & C, yellow 6-sunset yellow, FD & C yellow 5-Tartrazine

Question 22

Mostly used in chewable tablets

Answer 22

Flavoring agents

Question 23

Flavoring agents

Answer 23

Flavor oils

Question 24

TRUE OR FALSE
The dissultion of a drug depends on surface area of powder materials or granules

Answer 24

true

Question 25

for the movement of granules from hopper to die cavity sufficient flow properties are essential

Answer 25

true

Question 26

official tests

Answer 26

weight variation, disintegration, dissolution, drug content

Question 27

non official tests

Answer 27

hardness, fribality, general appearance

Question 28

crown thickness of individual tablets may be measured with

Answer 28

micrometer

Question 29

uses a spring applies diametrically to a tablet

Answer 29

stokes hardness tester

Question 30

force produced by a manually operated air pump

Answer 30

string cobb hardness tester

Question 31

makes use of hand pliers

Answer 31

pfizer tester

Question 32

makes use of hand pliers as aid

Answer 32

erweka tester

Question 33

horizontally positioned, eliminated operator variance

Answer 33

schleuniger

Question 34

acceptable hardness of ordinary compressed tablet

Answer 34

4-a0 kgf

Question 35

acceptable hardness of buccal tablet

Answer 35

7-10 kgf

Question 36

acceptable hardness of chewable tablet

Answer 36

2-3 kgf

Question 37

acceptable hardness of sublingual tablet

Answer 37

2-3 kgf

Question 38

acceptable hardness of sustained release tablet

Answer 38

10-20 kgf

Question 39

the tendency of tablets to powder, chip, or fragment which can affect the elegance appearance of the tablet

Answer 39

friability

Question 40

these tests can be performed to give indication of how well a tablet will hold up in its specified package and shipping container during shipment

Answer 40

friability friablity additional tests: vibration test drop tesst incline plane tests

Question 41

breakdown of the tablet into smaller particles or granules a process known as

Answer 41

disintegration

Question 42

a physiochemical process by which a solid substance enters the solvent phase to yield a solution

Answer 42

dissolution

Question 43

apparatus 1

Answer 43

basket

Question 44

apparatus 2

Answer 44

paddle

Question 45

apparatus 3

Answer 45

reciprocating cylinder

Question 46

apparatus 4

Answer 46

flow through cell

Question 47

apparatus 5

Answer 47

paddle over disk

Question 48

apparatus 6

Answer 48

rotating cylinder

Question 49

apparatus 7

Answer 49

reciprocating holder