Module 5 Lesson 1

Question 1

Criteria of uniformity of mixtures

Answer 1

Should contain 98-102% of the API

Question 2

methods of uniformity mixtures

Answer 2

coning, and quartering, thief sampler

Question 3

Criteria for adequacy of wetness

Answer 3

wet granulation

Question 3

qualitative testing to check if the binder added is enough

Answer 3

wet granulation

Question 4

Method of adequacy of wetness

Answer 4

damp mass - press thumb - ball crumbles under moderate pressure - next stage

Question 5

not enough binder. too many fines - produce soft tablets

Answer 5

underwetting

Question 6

may clog the screen, prolong processing(drying), forms very hard aggregates

Answer 6

overwetting

Question 7

method (moisture content

Answer 7

gravimetric method, moisture balance analyzer

Question 7

acceptable limit of moisture content

Answer 7

0.5% to 1%

Question 7

gravimetric method

Answer 7

weigh - oven - weigh - oven - until constant weight is achived

Question 7

adhesion of the granules to the die wall

Answer 7

sticking

Question 8

implications of moisture content

Answer 8

sticking, picking,capping,chipping,lamination

Question 9

adhesion of the granules to the pouch

Answer 9

picking

Question 10

complete/partial separation of the top or bottom part of the tablet

Answer 10

capping

Question 11

separation of small portions of the tablets

Answer 11

chipping

Question 12

separation into two or more layers of the tablet

Answer 12

lamination

Question 13

criteria for particle sice distribution

Answer 13

25 grams or more sample

Question 14

methods for particle size distribution

Answer 14

sieve machine, mesh #

Question 15

refers to the number of linear openings per square inch

Answer 15

mesh #

Question 16

Implications for particle size distribution

Answer 16

good granules, fines

Question 17

good granules

Answer 17

85 to 90%

Question 18

fines

Answer 18

10 to 15%

Question 19

are designed to sit in a stack so that material falls through smaller and smaller meshes

Answer 19

Standard sized sieves

Question 20

range of sieves

Answer 20

40-9500um

Question 21

the microscope eyepiece is fitted with a micrometer by which the size of the particles may be estimated

Answer 21

optical microscopy

Question 22

rage of optical microscopy

Answer 22

0.2 - 100um

Question 23

particles are individually examined

Answer 23

electron microscopy

Question 24

range of electron microscopy

Answer 24

0.001 - 5um

Question 25

smallest sieve opening through which 50% or more of the material passes

Answer 25

d50

Question 26

>1000

Answer 26

very coarse

Question 27

355-1000

Answer 27

coarse

Question 28

180-355

Answer 28

moderately fine

Question 29

125-180

Answer 29

fine

Question 30

90-125

Answer 30

very fine

Question 31

by measuring the terminal settling velocity of particles through a liquid medium in a gravitational centrifugal environment using Andreasen apparatus

Answer 31

Sedimentation

Question 32

range of sedimentation

Answer 32

0.8 - 300um

Question 33

apparatus used in sedimentation

Answer 33

andreasen apparatus

Question 34

distribution of scattered intensity is analysed by computer to yield the particle size distribution

Answer 34

light scattering technique

Question 35

light scattering techniques

Answer 35

laser diffraction particle size analysis, photon correlation spectroscopy

Question 36

characterize the flow property of granules/powders

Answer 36

angle of repose

Question 37

Characterized the compressibility of the powders

Answer 37

Compressibility index and hausners ratio