Module 4 Muscular Tissue Flashcards
Bundle of muscle fiber
Fascicle
thread like structures w/
contractile function
Myofibrils
finer structure inside myofibrils
Myofilaments
dense CT, surrounds whole muscle
Epimysium
thinner covering around fascicle or
a bundle of muscle fiber
Perimysium
delicate layer of reticular fibers
around each muscle fiber
Endomysium
cytoplasm of a muscle fiber
(acidophilic)
Sarcoplasm
plasma membrane of a muscle cell
Sarcolemma
linear unit, basic functional unit
of myofibril
Sarcomeres
granules in the sarcoplasm (under
EM is actually mitochondria)
Sarcosome
endoplasmic reticulum,
membranous sacs which encircles
each myofibril
Sarcoplasmic reticulum (SR)
Muscular Tissues: General Characteristics:
- Cells elongated (called fibers)
- Sarcoplasm
- Plasma membrane
- Acidophilic staining
- Contraction depends on
myofilaments
6.Cells held together by loose areolar
Connective Tissue containing blood
vessels and nerves
appears fibular
due to myofibrils
Sarcoplasm
Muscular Tissues: General Functions:
- Movement
- Posture maintenance
- Joint stabilization
- Heat generation
skeletal and smooth muscle aid in movement of
bones and fluids
Movement
skeletal muscles contract to maintain the body
position
Posture maintenance
tendons that cross over stabilize joint as the
muscle tone (constant low level contraction)
places tension on the tendon
Joint stabilization
muscular contractions generate heat influencing
body temperature
Heat generation
Muscular Tissues: Special Functions:
- Contractility (able to contract)
- Extensibility (able to extend)
- Excitability (able to become excitable)
- Elasticity
when long cells shorten simultaneously, pulling force is
created, contracts the muscle reduce overall size then
cause movement or stabilization
Contractility
at the end of contraction, muscle may return to
original length by relaxing or extending with the aid of
opposing muscle
Extensibility
muscle cells respond to nerve impulses
Excitablity
Recoils (back to it’s normal size) after stretch
Elasticity
Muscular Tissues: Composition
- Muscle fibers
- Loose areolar CT
outermost layer, a sheath of
dense connective tissue (CT) externally
surrounds the entire muscle
Epimysium
a sheath of fibrous CT
surrounding fascicles
Perimysium
a sheath of reticular fibers
surrounding the bundles within the fascicles
Endomysium
intercellular substance
that held together muscle fibers
Loose areolar CT
Types of Muscle tissue
- Skeletal muscle
- Smooth muscle
- Cardiac muscle
somatic
striated and voluntary muscles
Skeletal muscle
Have Intercalated disk
striated involuntary muscles
Cardiac muscle
plain/visceral or
non-striated/involuntary muscles
Smooth muscle
plain/visceral or
non-striated/involuntary muscles
Smooth muscle
walls of hollow organs
Smooth muscle
only in the wall of
the heart
Cardiac muscle
Attach to and move skeleton
Skeletal muscle
It is 40% of body weight
Skeletal muscle
Fibers = multinucleate cells (embryonic cells fuse)
Skeletal muscle
Cells obviously striated
*Contractions are
voluntary
Skeletal muscle
It is spindle or fusiform shaped
Smooth muscle
not branched and no striations
Smooth muscle
Cells somewhat compact in
arrangement
Smooth muscle
It has very scanty intercellular
subs (has least amount of
Loose areolar CT)
Smooth muscle
Few long slender
mitochondria
Smooth muscle
Scanty ribosomes and ER
*
Smooth muscl
Scanty ribosomes and ER
*
Smooth muscle
Sarcolemma showing pinocytic
vesicles
Smooth muscle
Single nucleus - bulging and
centrally located
Smooth muscle
Myofibrils of smooth muscle IS
non-stiriated
myofilaments of smooth muscle
not distinct
cannot consciously control movement
Involuntary
very slow and sustained
Is very fatigue resistant
Contraction
Distribution of smooth muscle
mainly in the walls of hollow visceral organs
-In blood vessels: walls of vein and arteries
-In reproductive and glandular systems
-in digestive and urinary systems:
-In integumentary system
smooth muscle In blood vessels: walls of vein and arteries
To regulate blood pressure and flow
smooth muscle in reproductive and glandular systems
To produce movements
Smooth muscle in digestive and urinary systems:
- forms internal sphincters of anus
- produces contractions
What causes goose bumps?
Arrestores pitorum or arrector pili muscles
Smooth muscle distribution
and its MAJOR LOCATION
- Inside the eye
- Respiratory tubes
- Urinary organs
- Reproductive organs
- Digestive organs
- Walls of vessels
NEED BASAHIN THIS
Lining of hollow visceral organs
* the walls of the digestive system ex. stomach,
bladder, respiratory passages
* Middle to lower part of esophagus
* Walls of ducts and glands associated with alimentary tract
* Walls of respiratory passages (trachea to alveolar ducts
urinary & genital ducts)
* Walls of arteries, veins & larger lymphatics
* Spleen
* Arrestores pitorum or arrector pili muscle (goose flesh)
* Iris & ciliary body of the eye concerned with accomodation,
constriction & dilation of pupil
* Areola of mammary gland
* Subcutaneous tissue of scrotum
Smooth Muscle: Functions MAJOR
To alter activity of various body parts to meet
needs of the body
SMOOTH MUSCLE: FUNCTIONS SPECIFIC
- Contraction of the bladder
- Move food through the intestines (peristalsis)
- Peristaltic movement to move feces down the
digestive system - Contraction of smooth muscle in the trachea and
bronchi w/c decreases the size of the airways - Constriction and dilation of blood vessels
- Constriction, accomodation and dilation of pupil
- Uterine contraction during birthing
It has characteristics of both
skeletal and smooth muscle
CARDIAC MUSCLE
Contractions lasts longer than
a skeletal muscle twitch
CARDIAC MUSCLE
It depends on aerobic
respiration to generate ATP
CARDIAC MUSCLE
It is very fatigue resistant
CARDIAC MUSCLE
Activation of cardiac muscle
is
INVOLUNTARY LIKE SMOOTH MUSCLE
CARDIAC MUSCLE HAS
INTERCELATED DISK
CELLS OF CARDIAC MUSCLE
Single spherical centrally located nucleus
(Branches have no nucleus)
CARDIAC MUSCLE THAT SERVE AS
junction between cardiac cells
intercalated disk of Eberth
FIBERS OF CARDIAC MUSCLE (SHAPE)
elongated ,branches, w/ numerous areolar CT
FIBERS THAT IS IN CARDIAC MUSCLE
Myofibrils striated w/ distinct actin & myosin
CARDIAC MUSCLE DISTRIBUTION
Muscle layer of the heart
o Walls of the aorta, vena cava and pulmonary
vessels
Muscle layer of the heart
MYOCARDIUM
FUNCTION OF CARDIAC MUSCLE
To provide the contractile activity of the
heart
IT IS A SPECIAL FUNCTION UNIT OF HEART
Conduction System of the Heart
responsible for generating and conducting
electrical impulses for the heart
CONDUCTION SYSTEM OF THE HEART
cause heart to contract and pump blood
throughout the body
CONDUCTION SYSTEM OF THE HEART
HEART IS Made up of 5 elements
- Sino-atrial (SA)
- Atrio-ventricular (AV) node
- Bundle of His
- Left and right bundle branches
- Purkinje fiber node
DISCOVERS SINOATRIAL NODE OR THE Pacemaker
, Node of Keith & Flack
Located below the epicardium at the junction of superior vena cava & right atrium
SINOATRIAL NODE
DISCOVER ATRIOVENTRICULAR NODE
NODE OF TAWARA
Located below the endocardium, on the lower part of
the interatrial septum
ATRIOVENTRICULAR NODE
Delays cardiac impulses from sinoatrial node to
allow atria to contract and empty the contents first
ATRIOVENTRICULAR NODE
Relays cardiac impulses to the atrioventricular
bundle
ATRIOVENTRICULAR NODE
bundle of fibers located within the septum of
the heArt
ATRIOVENTRICULAR BUNDLE OF HIS
Carries cardiac impulses down the
septum to ventricles via the Purkinje fibers
ATRIOVENTRICULAR BUNDLE
The right bundle carries nerve impulses,
cause contraction of right ventricle
LEFT AND RIGHT BUNDLE BRUNCHES
Left bundle carries nerve impulses that
cause contraction of left ventricle
LEFT AND RIGHT BUNDLE FIBERS BRUNCHES
Located beneath the endocardium on either side of
the cardiac septum
PURKINJE FIBERS
Relays cardiac impulses to ventricular cells
causing ventricle contraction
PURKINJE FIBERS
CHARACTERISTICS OF PURKINJE FIBER
- Pale in color
- Fewer branches, nuclei, striations
- Bigger in diameter
- Shorter in size
- Lies in abundant amount of loose areolar connective
tissue
CELLS OF SKELETAL MUSCLE
elongated cells that do not branch
w/ larger diameter
Nucleus: appears multinucleated
Flattened and peripherally located
FIBERS OF SKELETAL MUSCLE
Myofibrils are striated
W/ distinct myofilaments (actin & myosin)
Moderate amount of Loose Areolar CT
Without intercalated disk
myofibrils grouped into parallel
bundles longitudinally
“Kollicker’s Column”:
3 TYPES OF SKELETAL FIBERS
-RED FIBERS
-WHITE FIBERS OR FAST MUSCLE FIBER
-INTERMEDIATE FIBER
slow twitch high oxidative fibers
RED FIBERS
Appears red due to presence of muscle pigment
MYOGLOBIN
Have smaller diameter & sarcoplasm (IT HAS about half OF the diameter of fast fibers)
RED FIBERS
Contain numerous large sarcosomes
RED FIBERS
Rich blood supply > higher oxygen supply
RED FIBERS
According to function, contracts more
slowly so fatigue less quickly (running)
RED MUSCLE
take ~3x as long to reach peak tension after
stimulation
RED FIBERS
MANY MITOCHONDIRA
RED FIBERS
Energy source OF RED FIBERS
: oxidative phosphorylation
CHARACTERISTIC OF White Fibers / Fast Muscle Fibers
Larger diameter
o Pale due to less pigmeNT
o With smaller, functional sarcosome
o Poor blood supply
- MOST COMMON
- VERY FEW MITOCHONDIRA
-CONTAINS DENSELY PACKED MYOFIBRILS
Pale due to less pigment
(Less myoglobin)
reach peak twitch tension in 0.01 sec or less after
stimulation
WHITE FIBERS OR FAST MUSCLE FIBER
Similar with red fibers but with smaller
sarcosome
INTERMEDIATE FIBER
Contracts faster so fatigue more quickly
WHITE FIBERS OR FAST MUSCLE FIBER
ENERGY SOURCE OF WHITE FIBERS OR FAST MUSCLE FIBERS
anaerobic glycolysis (w/ large
glycogen reserves
embryonic cells that fuse to develop muscle fibers
MYOBLAST
unfused cells that remain in adult skeletal muscle
MYOSATELLITE CELLS
Dense sheet or broad band of irregular connective
tissue that surrounds muscles
FASCIA
plasma membrane of a muscle fiber surrounding the sarcoplasm (cytoplasm) containing mitochondria, and myofibrils
SARCOLEMMA
transverse tubule encircling a myofibril, storing
calcium for muscle contraction
SARCOPLASMIC RETICULUM
cylindrical bundles of myofilaments
MYOFIBRILS
LIE PARALLEL TO ONE ANOTHER
MYOFIBRILS
responsible for muscle fiber contraction
myofibrils
protein filaments
myofilaments
organization of these produce alternating
light/dark bands
MYOFILAMENTS
IF MYOFILAMENTS IS THIN IT IS COMPOSED OF
PRIMARILY ACTIN
IF MOFILAMENT IS THIC IT IS COMPOSED OF
PRIMARILY MYOSIN
Repeating functional units of
myofilaments responsible for muscle
contraction
SARCOMERES
approximately 10,000 end to end in a
myofibril
SARCOMERES
Contain: thick/thin filaments,
proteins
SARCOMERES
differences in size, density, and
distribution account for the banded
appearance
SARCOMERES
IN SARCOMERES Dark bands ARE
A BANDS
IN SARCOMERES LIGHT BANDS ARE
I BANDS
Separate one sarcomere from the next
Z discs/Z band (telophragma)
Thick and thin filaments overlap one anotheR
Z discs/Z band (telophragma)
Darker middle part of the sarcomere
A band (Anisotropic)
Lighter, has thin filaments but no thick filaments
I band (isotropic)
Center of each A band which contains thick but no
thin filaments
H zone/H band (intermediate disc of Hensen)
Supporting proteins that hold the thick filaments
together in the H zone
M line/M band (Mesophragma)
Myofibrils are built from three kinds of
proteins
- CONTRACTILE PROTEIN
- REGULATORY PROTEIN
- STRUCTURAL PROTEIN
Myofibrils are built from three kinds of
proteins
- CONTRACTILE PROTEIN
- REGULATORY PROTEINS
- STRUCTURAL PROTEIN
Generate force during contraction
CONTRACTILE PROTEIN
Switch the contraction process on and off
REGULATORY PROTEINS
Align the thick and thin filaments properly
STRUCTURAL PROTEINS
Provide elasticity and extensibility
STRUCTURAL PROTEIN
Link the myofibrils to the sarcolemma
STRUCTURAL PROTEIN
Functions as a motor protein which can
achieve motion
MYOSIN
Convert ATP to energy of motion
MYOSIN
Projections of each myosin molecule
protrude outward
MYOSIN HEAD
THICK FILAMENTS?
THIN FILAMENTS?
MYOSIN
ACTIN
molecules provide a site where myosin
head attach
ACTIN
iT IS also part of the
thin filament
Tropomyosin and troponin
Strands of tropomyosin cover the myosin-
binding sites
ACTIN
Stabilize the position of myosin
TITIN
2 STRUCTURAL PROTEINS OF SKELETAL MUSCLE
TITIN
DYSTROPHIN
accounts for much of the elasticity and
extensibility of myofibrils
TITIN
Links thin filaments to the sarcolemma
DYSTROPHIN
BABY!! BASAHIN MO TONG THEORY NI HUXLEY THE SLIDING THEORY OF HUXLEY NEED BASAHIN TO HA <3
-PAEZ
OKAY SABI MO BABY EH
fiber is stimulated to contract
* actin and myosin filaments react by past sliding by
each other but w/ no change of length
o Thick myosin strand in A band is stationary
o Thin actin filament attached to Z discs extend further
into A band
o May eventually obliterate the H line
o The thin filaments attached to Z disc drawn toward
each other
o Sarcomeres are compressed, myofibrils shortened and
contraction occurs
o Note: contraction occur not because of shortening but
due to increase in the overlap b/w filaments
SKELETAL MUSCLE DISTRIBUTION
-WIDELY DISTRIBUTED
-Tongue & upper part of the esophagus
attached to entire skeletal system of the
body
external urethra & external anal
sphincter
lower part is involuntary in nature
Tongue & upper part of the esophagus
although unattached to the skeletal
system, it is classified as striated voluntary
Tongue & upper part of the esophagus
Similar with red fibers but with smaller
sarcosome
Intermediate fiber
Speed of contraction is comparable to that
of the white fibers
Intermediate fiber
is blocked from binding to actin
Myosin