Module 3 Connective tissue Part 3 Flashcards
Are found in areas of adjacent bones. They
are covered and held together firmly by
connective tissues
Joints
The degree of movement between the bones
are defined by the
Joints
Classification of joints
- Synarthroses
- Diarthroses
it permits very limited
movements or no movement at all.
Synarthroses
permits bone to move freely
examples: elbow and knee
Diarthroses
Can be subdivided into cartilagenous and fibrous joints which depends on the tissues that binds the joints
Synarthroses
Major subtypes of Synarthroses
- Synostoses
- Syndesmoses
- Symphyses
bones are jointed only by bones. Does not
allow movement
Synostoses
only dense connective tissue unites the
bones
Syndesmoses
immobile joints. Ends are covered by pad
of fibrocartilage between articular cartilage
Symphyses
example of Symphyses
Pubic symphysis
examples of Synostoses
unite the skull bones of older adults
example of Syndesmoses
posterior region of the sacroiliac
joints
Proper alignment of the bones are maintained by the ligaments and capsule of dense connective tissue
Diarthroses
Joint cavity sealed capsule that contains synovial
fluid.it is lined by specialized connective tissue
called synovial membrane
Diarthroses
extends fold and villi to the
cavity and secretes synovial fluid which act as
lubricant
Synovial membrane
came from plasma., with higher
concentration of hyaluronan
Synovial fluid
secreted by the cells of synovial
membrane
Hyaluronan
2 specialized cells in synovial membrane
- Macrophages
- Fibroblastic synovial cells or type B cells
-like synovial cells or type A
cells
Macrophages
derived from monocytes, remove wear -and –tear
debris from the synovial fluid
Macrophages
Regulate inflammation that may take place in the
diarthrotic joints
Macrophages
Produce lots of hyaluronan and extracellular
components
Fibroblastic synovial cells or type B cells
Lubricates the joints to reduce friction, supplies
oxygen and nutrients to the articular cartilage
Fibroblastic synovial cells or type B cells
Specialized type of connective tissue
- Cartilage
- Bone
- Blood
Rbc production
Erythropoiesis
Hormone that stimulates the rbc production
Erythropoietin
Produced by the kidney
Erythropoietin
Decreased number of circulating rbc
Erythrocytopenia
Decreased in oxygen carrying capacity of rbc
Anemia
Not a disease but a symptom
Anemia
Rbc is bigger than its normal size
Macrocytic
Rbc is smaller than its normal size
Microcytic
Rbc in normal size
Normocytic
Variation in rbc shape
Poikilocytosis
Variation in rbc size
Anisocytosis
Rbc appearing darker than normal due to increased hgb content
Hyperchromic
Rbc appearing paler due to decreased hgb
Hypochromic
Rbc with normal hgb content
Normochromic
Specialized Type of Connective tissue
C. Blood
- Erythropoiesis
- Erythropoietin
- Erythrocytosis
- Erythrocytopenia
- Anemia.
- Macrocytic
- Microcytic
- Normocytic
- Poikilocytosis
- Anisocytosis
- Hyperchromic
- Hypochromic
13.Nomochromic
is pumped by the rhythmic contractions
of the heart flowing in a single direction at a
close circuit called circulatory system.
Blood
A specialized connective tissue has
fluid extracellular matrix known as plasma, with
suspended cellular elements
General function of specialized Type of Connective tissue
C. Blood
- Transport
- Maintain/regulate-Homeostasis
- Serve as body’s defense mechanism against
infection
Specialized type of CT
C. Blood
Transports
– oxygen & carbon dioxide
– nutrients to tissues and organs
– hormones to target organs
Specialized type of CT
C. Blood
Maintain/regulate-homeostasis
– water, acid-base balance
– body temp
– degree of irritability of tissues
Specialized type of CT
C. Blood
Characteristics
1.pH- slightly basic ( 7.35-7.45)
2. Higher density & viscosity than water
3. Blood volume is around 8% of total body
weight
4. Blood is composed of 55% plasma and
45% cellular elements
Why does specialized Type of Connective tissue
Blood have Higher density & viscosity than water
due to formed elements
Blood total body weight to
Male?
Female?
Male 5-6 liters
female 4-5 liters
Specialized type of CT
C. Blood
Components
- Liquid components
- Formed components
2 types of liquid components
- Plasma
- Serum
colorless fluid & 90% H2O
Plasma
Components of plasma
Components: water, Inorganic salts (Na, Ca, Mg,
K, Cl2, PO4, BiCO3) & plasma proteins (Albumin,
Globulin & fibrinogen)
Gases: N, H, O2
The fluid matrix of whole blood
Plasma
liquid portion of clotted blood w/o fibrinogen
Serum
Contains growth factors and other proteins
released by the platelets during clotting process
Serum
3 types of formed elements
- Erythrocytes or Red blood cells
- Leukocytes or White blood cells
- Thrombocytes or Platelets
Erythrocytes
MATURATION TIME?
SURVIVAL TIME
3-5 DAYS
120 DAYS
GRANULOCYTES
MATURATION TIME?
SURVIVAL TIME
5-6 DAYS
Neutrophil- 1-4 days
Eosinophils- 1-2 weeks
Basophils- Several months
MONOCYTES
MATURATION TIME?
SURVIVAL TIME
5-6 DAYS
HOURS-YEARS
LYMPHOCYTES
MATURATION TIME?
SURVIVAL TIME
variable
(days-hours)
HOURS - YEARS
PLATELETS
MATURATION TIME?
SURVIVAL TIME
4-5 DAYS
10
Characteristic of Erythrocytes
Biconcave disc (6-8μ in diameter)
Formed in the bone marrow
Non-nucleated
Ave life span of 30-120days
Oxygen binding pigment responsible for the
transport of most O2 in the body
Hemoglobin
Compound of iron and protein
Hemoglobin
Combined readily with O2 to form oxyhemoglobin
Hemoglobin
Hemoglobin combines with O2
Oxyhemoglobin
Characteristic of
Leukocytes or white blood cells
Has nucleus and cytoplasm
Types of leukocytes
- Granulocytes
- Agranulocytes
Types of leukocytes
- Granulocytes
- Agranulocytes
Types of Agranulocytes
- Lymphocyte
- Monocytes
Types of Granulocytes
- Neutrophil
- Eosinophil
- Basophil
- Stab or band or staff cell
Cytoplasmic characteristics of neutrophil
With fine lilac-pink granules diffusedly distributed
* Granules do not lie in over the nucleus
Nuclear characteristics of neutrophil
Nuclear lobes connected by thin filaments
* Coarse and clumped chromatin
Has active role in the phagocytosis of
bacteria and other small particles
Neutrophil
Usually the first leukocyte to arrive
at the site of infection
Neutrophil
Cytoplasmic characteristics of Eosinophil
Reddish-orange large granules
* Granules do not lie in over the nucleus
Nuclear characteristics of Eosinophil
Nuclear usually segmented 2 lobes
* Coarse and clumped chromatin
Helps in killing parasitic worm or helminths
with the help of Major Basic Protein that is
present in eosinophil together with
eosinophil peroxdase and other enzymes and
toxins
Eosinophil
Modulates inflammatory responses through
releasing of chemokines, lipid mediators and
cytokines
Eosinophil
Has important role in inflammatory
response due to allergies
Eosinophil
Cytoplasmic characteristics of Basophil
- Bluish-black with variable size granules
- Granules unevenly distributed and lie in over
the nucleus
Nuclear characteristics of Basophil
Nucleus is indistinct
* Unsegmented or bilobed nucleus
Release heparin, histamine &
peroxidase
Basophil
Involved in intermediate & delayed
hypersensitivity reaction
Basophil
Cytoplasmic characteristics of Stab or band or staff cell
Similar to neutrophil with lilac granules
* Indentation is not more than ½ of the total cell
width of cell’s indent point
Nuclear characteristics of Stab or band or staff cell
Nucleus is curved, elongated or sausage shaped
Cytoplasmic characteristics of small or typical lymphocytes
- Sky blue
- Small amount with darkest blue cytoplasm
- Lacking granules
Nuclear characteristics of small or typical Lymphocytes
- Nucleus is compact, large, round
- Almost occupies entire cell
Cytoplasmic characteristics of big or atypical Lymphocytes
Sky blue
* Abundant cytoplasm
Nuclear characteristics of big or atypical Lymphocytes
- Nucleus is immature looking with fine chromatin
Has different roles in immune
defense from invading
microorganisms, some parasites and
abnormal cells
Lymphocytes
Cytoplasmic characteristics of Monocytes
- Blue gray cytoplasm
Nuclear characteristics of Monocytes
- Single nucleus ,partially lobulated, deeply
indented or horseshoe shaped
Chromatin are fine parallel strands
Precursor of macrophages and cells in
connective tissues like osteoclast,
microglia
Monocytes
Monocyte-derived cells serves as
antigen presenting cells which is
important role in immune response
Monocytes
Irregular fragments of cells formed in the
bone marrow
Thrombocytes
Thrombocytes is from a much larger cell called
Megakaryocytes
Non- nucleated and difficult to count
Thrombocytes
Lightest element of blood
Thrombocytes
Adhere easily on surface
Thrombocytes
– Easily disintegrates
Thrombocytes
Maintain the integrity of BV
Thrombocytes
Forms hemostatic plugs to stop blood
loss from injury vessels
Thrombocytes
Releases serotonin
Thrombocytes
2-4μm in diameter
Thrombocytes
Cell size-14-20 um
Monocytes
Cell size- 12-15 um
Big or atypical lymphocyte
– Cell size- 6-10 um
Small or typical lymphocyte
Cell size- 10-15 um
- Neutrophil
- Eosinophil
- Stab or band or staff cell
Cell size- 10-14 um
Basophil