module 4 (exam 3) - animal diversity Flashcards
define the cochlea
a coiled, fluid-filled tube where sound energy is transduced to electric signals
sound pressure waves travel through the _____ and vibrate the _____
auditory canal; tympanic membrane
the _____ transmit vibrations of the tympanic membrane to the oval window of the _____
ossicles; cochlea
vibrations at the _____ create pressure waves in fluid-filled cochlear canals
oval window
pressure waves in _____ flex adjacent membranes
cochlear canals
when the _____ is flexed, it bends sterocilia on hair cells in the _____
organ of Corti
the movements of sterocilia are transduced into action potentials in the _____
auditory nerve
define the skeletal system
what most animals use for a rigid support structure to attach muscles to and move
define a hydrostatic skeleton
a volume of fluid enclosed inside a body cavity & surrounded by muscle
who has hydrostatic skeletons?
soft bodied invertebrates (ex. worms)
define an exoskeleton
an external skeleton - a rigid outer surface to which muscles are attached
who has exoskeletons?
arthropods & insects
define an endoskeleton
an internal skeleton covered by other, soft body tissues
who has endoskeletons?
vertebrates
what causes the rigidity of animals with hydrostatic skeletons?
high internal fluid pressure
in what parts of the body do humans rely on a hydrostatic skeleton?
in the discs of vertebral columns and in articular cartilage of joints
_____ cause segments of exoskeletal animals to move
muscle contractions
which animals have simple exoskeletons? which have complex?
mollusks have simple
arthropods have complex
define a cuticle (skeletal)
a type of exoskeleton that covers the outer surface of arthropods
exoskeletons are made of what?
chitin - a nitrogen containing polysaccharide
what are the 3 bone shapes in an endoskeleton?
rod, plate, or tube-like
in an endoskeleton, bones are attached to each other with what?
joints
what are the 2 types of connective tissues in an endoskeleton?
cartilage and bone connective tissue
define cartilage cells
a matrix of tough & rubbery mix of polysaccharides & collagen protein
what 2 types of places in the body is cartilage found in?
where stiffness & resilience are needed (ex. joints)
stiff & flexible supportive structures (ex. nose & voice box)
what is bone made of?
collagen fibers & calcium phosphate
what makes bone hard?
calcium phosphate crystals
bone is a reservoir for what?
calcium
what are the 3 types of living cells of bone?
osteoblasts, osteocytes, and osteoclasts
what is the function of osteoblasts?
put new matrix material on bone surfaces
what is the function of osteocytes?
former osteoblasts that are now inside cavities in bone
what is the function of osteoclasts?
break down old bone & release calcium from bone into extracellular fluid
what are the 2 main types of bone?
membranous bone & cartilage bone
what is the function of membranous bone?
give an example of where it is found
forms on a scaffold of connective tissue membrane
found on outer bones of skull
what is the function of cartilage bone?
give an examples of where it is found
first forms as a cartilaginous structure that looks like future mature bone, then slowly hardens/ossifies into bone
found in bones of limbs
T or F: cartilage bone can grow through the ossification process
true
in what direction does ossification proceed?
first in the center of long bone, then outward at ends
define epiphyseal plates
places where cartilage that forms between ossification centers
what is compact bone?
solid & hard bone that forms the hard white outer region
what is cancellous bone like?
it is rigid but has internal cavities & looks spongy
define bone marrow
living tissue that stores fat or produces red blood cells in bone cavities
define spongy bone
it is honeycombed with many small cavities within compact bone
where is spongy bound found within a bone?
more at the ends of long bones
define a joint
2 or more bones coming together
muscles can work in how many directions?
only 1
define tendons
straps of connective tissue that connect muscles to bones
define ligaments
attach bone to bone
define a fulcrum (lever systems)
a joint between where the load is and where the force is
define a load arm (lever systems)
the distance between the load & fulcrum
define a force arm (lever systems)
distance between force & fulcrum
what is the function of a class 1 lever?
give an example in the human body
the load moves opposite direction as application of force
ex. raising chin puts force on muscles in back of neck
where is the fulcrum located relative to the load and force in a class 1 lever?
fulcrum located equally between force & load points
what are the relative locations of the fulcrum, load, and force points in a class 2 lever?
load is located between the fulcrum and the points of force application
what is the function of a class 2 lever?
give an examples in the human body
makes it possible to move heavy objects a short distance
ex. standing on tip toes (fulcrum) applies force to calf muscle
what are the relative locations of the fulcrum, load, and force points in a class 3 lever?
point of force application is between the fulcrum and the load
what is the function of a class 3 lever?
give an examples in the human body
makes it possible to move loads over large distances & with speed
ex. throwing a ball - load is in hand, force is in bicep, fulcrum is elbow
define incisors (teeth)
teeth at front of the mouth
define canines (teeth)
specialized teeth for piercing prey bodies
define premolars (teeth)
teeth in back (next to canines) adapted for crushing and shredding tougher foods
define molars (teeth)
teeth in way back adapted for crushing and shredding tougher foods
what is the temporomandibular joint?
in mammals, a specialized jaw joint
how many teeth do adult humans have?
32
define adaptive radiation
diversification of one species into many that live in different habitats
define pathogens
harmful organisms and viruses that can cause disease
an animal’s defense system depends on what?
the ability to recognize between the animal’s own molecules and the invader’s
what are the 3 phases of the defense system?
recognition, activation, and effector
name 6 human defense systems that are present at all times
defenses in the airway, skin, eyes, ears, nose, and digestive tract
name 4 defense systems that animals besides humans may have
barks, leaf cuticle, exoskeleton, egg shells
define the innate/nonspecific defense mechanism
a genetically inherited mechanism that provides the first line of defense against pathogens
which animals have innate defense mechanisms?
all animals
define adaptive defenses
mechanisms aimed at specific pathogens
which animals have adaptive defense mechanisms?
only vertebrates
adaptive defenses are activated by what?
innate immune system
define antibodies
proteins that recognize, bind, and help destroy specific pathogens
antibodies can be made by what defense system?
adaptive only
define immunity
when an organism has sufficient defenses to avoid biological invasion by a pathogen
which protein is critical to immune response?
what does it do?
toll proteins begin a cascade that eventually produces defense molecules
what does PAMPs stand for?
pathogen-associated molecular patterns
T or F: there is no coordination between innate and adaptive immune responses
false - there is coordination
define white blood cells AKA leukocytes
specialized cells for immune system functions
define phagocytes
large cells that ingest pathogens by phagocytosis
define lymphocytes
adaptive & innate immunity cells including T & B cells
what type of cell is a mast cell?
what is the function of mast cells?
phagocyte
releases histamine & other signals that constrict blood flow from a wound and increase blood flow to a wound area
what type of cell is a neutrophil?
what is its function?
phagocyte
stimulates inflammation & kills invading cells via phagocytosis
what type of cell is a macrophage?
what is its function?
phagocyte
releases cytokines that recruit other cells to a wound site and stimulates activities in wound area, also kills cells by phagocytosis
what 4 places in the human body is lymphoid tissue found?
thymus, bone marrow, spleen, & lymph nodes
define blood plasma
blood solution with ions, small molecule solutes, and soluble proteins
define lymph
a fluid derived from blood and other tissues but has no red blood cells
what are 3 things in the first line of innate defense?
skin, mucous membranes, and chemicals
what are 5 things in the second line of innate defense
phagocytosis, complement proteins, interferons, inflammation, fever
the first line of defense is _____ (physical barrier; cell) derived and the second line of defense is _____ (physical barrier; cell) derived
physical barrier, cell
define mucous
a barrier defense against pathogens in innate immunity in animals - secreted by mucous membranes
define lysozyme
an enzyme in saliva, tears, and nasal secretions that hydrolyzes bacterial cell walls
define defensins
a type of protein made by phagocytes that kills bacteria and enveloped viruses by insertion into their cell membranes
pattern recognition receptors (PRRs) do what?
recognize nonself molecules
define natural killer cells
a class of lymphocytes - distinguish infected body cells and lyse pathogens
define inflammation
tissue response to an injury or infection
includes redness, swelling, and heat
define allergic reactions
a harmless, nonself molecule binds to mast cells which cause a release of histamine and inflammation
define autoimmune diseases
immune systems can’t tell difference between self & nonself molecules & attacks the body
define sepsis
inflammation from an invading bacterial infection spreads throughout the body, dilating blood vessels and dropping blood pressure
name 5 characteristics of the innate immune system
occurs in all animals
both cell-mediated and secreted components
rapid response
broad response against pathogens
no memory when infections recur
name 5 characteristics of the adaptive immune system
occurs only in vertebrates
both cell-mediated and secreted components
slow response
specific response against pathogens
memory & speed when infections recur
what experiment led to learning how immunity works?
testing diptheria using guinea pigs & injecting them with blood serum
define active immunity
acquired immunity from one’s own production of antibodies in response to presence of nonself molecules
define passive immunity
the process of acquiring immunity from antibodies received from another individual
what are the 2 parts of adaptive immunity?
humoral and cell mediated
how does humoral adaptive immunity work?
through body fluids - does not require cell to cell contact
utilizes B cells that make circulating antibodies active against extracellular pathogens
what are B cells (lymphocytes) & what is their function?
white blood cells that produce antibodies
how does cell mediated (AKA cellular) adaptive immunity work?
requires cells to contact one another to work
uses T cell receptors and T cells directed towards fighting off pathogens
what is a T cell receptor and what are its functions?
a protein complex found on the surface of T cells that is responsible for recognizing fragments of antigens
what is a T cell (lymphocyte) and what are its functions?
white blood cells responsible for responding to antigens, including allergies & tumors
name 4 key features of adaptive immunity that make it successful?
specific production of antibodies and binding of antigens
ability to distinguish self and nonself molecules
ability to respond to many nonself molecules
immunological memory
define immunological memory
the immune system’s ability to remember antigens on a particular type of pathogen that it had previously come into contact with
define antigen
any (foreign) molecule that elicits an immune response
define epitopes (AKA antigenic determinants)
sites/regions on the antigen that bind to T cell receptors & antibodies to be recognized by the immune system
compare primary vs secondary immune responses
primary: after 1st antigen infection, antibodies & T cells are produced
secondary: after 1st immune response, is faster & more powerful than primary response
define herd immunity
idea that an unvaccinated person won’t get sick because their probability of contacting an infectious person is low
what is the required % of immune people in a population to achieve herd immunity?
90% - different sources say different things
define cytotoxic T cells
workhorses of cellular immune system - can kill many strong pathogens including cancer cells
what are the 3 phases of immune responses?
recognition, activation, and effector
what happens during the recognition phase?
an antigen is inserted into the cell membrane of an antigen-presenting cell with unique antigen binding structures protruding from the cell membrane
what happens during the activation phase?
T-helper cells recognize the antigen on a cell & further propagates & releases cytokines that stimulate B & cytotoxic T cells
what happens with humoral immunity during the effector phase?
cells of B clones make antibodies, which bind to pathogenic cells - bound antibodies attract phagocytes to ingest & destroy the pathogen
what happens with cellular immunity during the effector phase?
clones of cytotoxic T cells bind to cells with antigens exposed & destroy them
define T-helper cells
T cells that have receptor proteins for specific antigens
antibodies (AKA immunoglobulins) have how many antigen-binding sites?
what is the name classifying this #?
minimum of 2 sites
bivalent = 2
antibodies have how many polypeptide chains? how are they classified?
4 chains - 2 long heavy chains and 2 short light chains
define agglutination
binding of multiple antigens and multiple antibodies
IgG antibodies many up what % of total circulating antibodies?
80%
what is the structure of IgG antibodies & where are they found in the body?
monomers
found free-floating in blood plasma
define opsonization
a process by which microbes in blood and tissue fluids bind IgG antibodies and thereby are “tagged” for destruction by phagocytes
give the process of opsonization by IgG antibodies (2 steps)
1) antibody molecules bind to pathogen AND to receptors on the surface of a macrophage
2) binding of the antibodies to receptors activates phagocytosis
define a monoclonal response
immune response against a single epitope - creates a single clone of B cells
define a polyclonal response
immune response against multiple epitopes - creates multiple clones of B cells
define antigen presentation
fragments on the cell surfaces that function as antigens
what are the benefits of antigen presentation?
allows interaction & communication between innate and adaptive immune systems
different types of immune cells are all derived from what type of cells (and where are they found)?
stem cells in bone marrow
stem cells in bone marrow make a first differentiation into what 2 kinds of stem immune cells?
myeloid stem cells & lymphoid stem cells
lymphoid stem cells go on to produce what 2 immune cells?
where are the 2 types found?
B lymphocytes (mature in bone marrow)
T lymphocytes (mature in thymus)
what does binding of cytotoxic T cells result in?
causes the death of the cell displaying the antigen
what does binding of T-helper cells result in?
activation of the adaptive immune response
define the major histocompatibility complex (MHC)
a genetic system that allows large proteins in immune system cells to identify compatible or foreign proteins
what 3 cell types are used in cellular immunity effector cells?
cytotoxic T cells, T-helper cells, and MHCs
give 4 characteristics of a T cell receptor’s structure
has a place for antigens & MHC to bind
is a glycoprotein
has 2 polypeptide chains (alpha and beta)
has both variable and constant regions
T cell receptors can only bind to antigens when?
when there is an MHC protein on the surface of the antigen-presenting cell
where are MHC I molecules present?
on the surface of every nucleated cells in mammals
where are MHC II molecules present?
on the surfaces of macrophages, B cells, and dendritic cells
define “tregs”
regulatory T cells - ensure that immune responses don’t get out of control, mediate tolerance to self antigens
how do tregs function (2 steps)
1) treg cell binds to the MHC complex of a cell presenting a self-antigen
2) if a Tc or TH cell is also bound to the antigen-presenting cell, the treg releases cytokines, which suppress the Tc or TH cell response and cause apoptosis
define human immunodeficiency virus (HIV)
a retrovirus that attacks the body’s immune system
define acquired immune deficiency syndrome (AIDS)
a disease that results from an HIV infection once it has progressed to a certain point
how does HIV/AIDS take over the body?
reduces # of T-helper cells, macrophages, & antigen-presenting dendritic cells, which allows HIV infection to increase and destroys immune response ability
define zoonosis
a disease that can be given to humans from animals
define a vaccine
either an inactive form of a pathogen or an antigenic compound of the pathogen
how does a vaccine promote immunity?
it generates memory cells without making the person sick
define endocrine cells
cells that secrete hormones into blood
which 2 types of body cells work together to control other cell types in the body?
endocrine and nerve cells
define a target cell
a cell that receives a chemical signal from a nerve or endocrine cell
what are the 2 main differences between the endocrine and nervous systems?
endocrine: slow and broadcast
nervous: fast and addressed
define broadcast
the signal sent affects many other cells on the way to affecting the target cell
how does the endocrine system transfer hormones?
through the blood
define addressed
the signal sent only affects the target cell
how does the nervous system transfer signals?
through chemical signaling