Module 4 Flashcards
what the drug does to the body
pharmacodynamics
what the body does to the drug
pharmacokinetics
Pharmacokinetics includes:
absorption
distribution
metabolism
excretion
pharmacodynamics includes:
receptors
ion channels
enzymes
carrier proteins
method and rate at which drugs leave site of administration
absorption
(small intestine or liver)
after the drug leaves the systemic circulation and enters the cells
distribution
why elderly may experience toxicity
high fat, low protein
steady state
drug eliminated is equal to dose administered
half life
time to clear 50% of drug from plasma
elimination
takes 5 half lives to completely eliminate drug
Long-acting injectable pharmacokinetics
rate of absorption is slower than elimination.
20% of Asians have _____
reduced activity of 2C19 enzyme
Common Inhibitors
bupropion
clomipramine
cimetidine
SSRIs
Common inhibitors (2)
fluoroquinolones
clarithromycin
grapefruit juice
ketoconazole
nefazodone
common inducers
carbamazepine
st. john’s wort
phenytoin
phenobarbital
tobacco