Module 3 Psychiatry Drugs Flashcards
Trazodone
Serotonin antagonist and (weak) reuptake inhibitor
Antagonises Alpha-1 adrenergic receptor
Antagonises serotonin receptor 5-HT2A
Indicated for depression
SE: Drowsiness (H1 receptor blocker), orthostatic hypotension
Max dose: 600mg
Licensed 1970
Half life: 13 hours
Line of treatment: Second
Clozapine
Atypical antipsychotic
Highest affinity to D2 (nigrostrial and mesocortical) (antagonist), GABA agonist and 5HT2a antagonist
Due to being more specific, reduces SE
Indicated for Schizophrenia, mania and agitation
SE: Constipation, neutropenia, anticholinergi, NMS
Max dose: 900 mg
Licensed: 1972
Half life: 8 hours
Line of treatment: 3rd line
Citalopram
Selective serotonin reuptake inhibitor
Indicated for Anxiety and depression
SE: Suicidality can be increased, prolonged QTc (pronounced), dizziness and sleep disturbances.
Max dose: 40 mg
Licensed: 1995
Half life: 33 hours
Line of treatment: 1st
Aripiprazole
Atypical antipsychotic
Partial D2 agonist (mesolimbic, mesocortical, nigrostrial)
Indicated for Agitation, Mania and Schizophrenia
SE: Constipation, Agitation
Max dose: 30 mg
Licensed: 2002
Half life: 75 hours
Line of treatment: 1st
Paroxetine
Serotonin antagonist and reuptake inhibitor
Indicated for Depression, PTSD, menopausal symptoms
SE: Increased suicidality, prolonged QTc, dizziness and sleep disturbances
Max dose: 40 mg
Licensed: 1992
Half life: 21 hours
Line of treatment: 1st
Olanzapine
Atypical antipsychotic
D2 (mesolimbic, nigrostrial and mesocortical) and 5HT2a
Indicated for Schizophrenia, mania and agitation
SE: Constipation, anticholinergics
Max dose: 20 mg
Licensed: 1971
Half life: 30 hours
Line of treatment: 1st
Lorazepam
Benzodiazepine
Positive allosteric modulator of GABA
Indicated for Convulsions, agitation and anxiety
SE: COma, respiratory depression
Max dose: 4 mg
Licensed: 1963
Half life: 12 hours
Line of treatment: 2nd
Zopiclone
Benzodiazepine
Positive allosteric modulator of GABA receptors
Indicated for Insomnia
SE: Coma, respiratory depression
Max dose: 7.5 mg
Licensed: 1986
Half life: 4 hours
Line of treatment: 1st
Haloperidol
Typical antipsychotic
D2 (mesolimbic, nigrostrial, mesocortical)
Indicated for Nausea, Tic disorders, Agitation, Mania, Delirium and Schizoephrenia
SE: EPSES, NMS, and QTc prolongation
Max dose: 20 mg
Licensed: 1958
Half life: 40 hours
Line of treatment: 2nd
Fluoxetine
SSRI
Indicated for Depression, OCD, bulimia, PTSD and menopausal symptoms
SE: Increased suicidality, prolonged QTc, dizziness and sleep disturbaces.
Max dose: 60 mg
Licensed: 1986
Half life: 5 days
Line of treatment: 1st
Chlorprozamine
Typical antipsychotic
D2 antagonist (mesolimbic, mesocortical and nigrostrial)
Indicated for Nausea, hicups and schizophrenia
SE: EPSES, NMS and QTc prolongation
Max dose: 1g
Licensed: 1972
Half life: 36 hours
Line of treatment: 2nd
Amitruptyline
Tricyclic antidepressant
Blocks serotonin and noradrenaline reutake, also affects H1/2 and alpha receptors. Some affinity to NMDA receptor.
Indicated for Depression, chronic pain and migraine prophylaxis
SE: Often lethal in overdose, anticholinergic syndrome and GTc prolongation
Max dose: 150mg
Licensed: 1961
Half life: 25 hours
Line of treatment: 3rd
Quetiapine
Atypical antipsychotic
5HT2a and D2 (mesolimbic, nigrostrial and mesocortical). blocking 5HT2a increases dopamine.
Indicated for Schizophrenia, mania and depression
SE: Constipation, anticholinergic
Max dose: 800mg
Licensed: 1997
Half life: 7 hours
Line of treatment: 1st
Lofepramine
Bocks reuptake of Serotonin and Noradrenaline and also affects H1/2 and alpha receptors.
Newer TCAs are less danferous in overdoes
Indicated for Depression
SE: Anticholinergic syndrome
Max dose: 210mg
Licensed: 1983
Half life: 18 hours
Line of treatment: 3rd
Sertraline
Most commonly prescribed antidepressant. SSRI.
Indicated for Depression, anxiety, OCD and PTSD
SE: increased suicidality, prolonged QTc, dizziness and sleeo disturbances.
Max dose: 200mg
Licensed: 1991
Half life: 26 hours
Line of treatment: 1st
