Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

HEMA II LEC > MODULE 3 > Flashcards

MODULE 3 Flashcards

1
Q

Platelets arises from a unique cell of the bone marrow known as?

A

Megarkaryocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How many megakaryocytes are seen in 10x low power field?

A

2-4 megakaryocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What progenitor cell that will differentiate eventually into the formation of megakaryocytes and platelets?

A

CFU-GEMM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Megakaryocyte differentiation can also be suppressed by another transcription gene

A

MYB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Megakaryocyte are under what lineage?

A

Common myeloid progenitor cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

This is a counterpart of megakaryocyte lineage from erythrocyte lineage?

A

BFU-Meg/Burst Forming Unit-Megakaryocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Formation of hundreds colonies

A

BFU-Meg/ Burst Forming Unit-Megakaryocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Only produce dozens of the colonies

A

CFU/Colony Forming Unit-Megakaryocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Undergoes unique type of mitosis which is endoreduplication/endomitosis

A

LD-CFU-Meg/ Light Density - Colony Forming Unit- Megakaryocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Mitosis happens within the nucleus but there is no cytoplasmic dividion

A

Endomitosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Friend of GATA1, a transcription factor or gene which facilitates and help for the function of GATA1

A

FOG1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Mediates the switch from mitosis to endomitosis

A

RUNX1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

This pathway is needed for cytokinesis to take place

A

Rho/ROCK Pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Responsible for polyploidization

A

NF-E2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Earliest pre-cursor and the most immature recognizable cell in the lineage

A

Blast cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

There is a plasma membrane blebs or blunt projections

A

Megakaryoblast (MK-I)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

This stage is the end of endomitosis

A

Promegarkaryocyte (MK-II)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

The cytoplasm is azurophilic or lavender and granular and the endomitosis is absent

A

Megakaryocyte (MK-III)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Stain used to recognize the formation of lobules in megakaryocyte

A

Propidium Iodide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

If it is still attached from the membrane

A

Proplatelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Unique structure of megakaryocyte

A

Demarcation Membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Formation of bleb and pseudopodia is due to

A

Disarrangement or deformation of microtubules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

TPO receptor site present at all maturation stages

A

MPL/Myeloproliferative Leukemia

24
Q

Stem cell and common myeloid progenitor marker, disappears as differentiation proceeds

A

CD34

25
Q

Main hormone or growth factor which needed for the maturation of the platelet

A

Thrombopoietin

26
Q

Only present until the LD-CFU-Meg

A

CD34

27
Q

Can only be detected in MK-III and platelet

A

Cytoplasmic Coagulation

28
Q

Circulates as a hormone in plasma and is the ligand that binds the megakaryocyte in and MPL

A

Thrombopoietin

29
Q

Act in synergy with TPO to induce the early differentiation of stem cells

A

IL-3

30
Q

Act in the presence of TPO to enhance endomitosis megakaryocyte maturation and thrombocytopoeisis

A

IL-5 AND IL-77

31
Q

Also known as kit ligand or mast cell growth factor

A

Stem Cell Factor

32
Q

Lifespan of platelets

A

7-10 days

33
Q

Other term for thrombocytopoeisis

A

Platelet shedding/budding, thrombopoeisis

34
Q

Shape of platelets in EDTA

A

Round up

35
Q

Counter part of Mean Corpuscular Volume that measures the volume of the RBC

A

Mean Platelet Volume

36
Q

Pieces of megakaryocyte cytoplasm which is formed because of platelet shedding

A

Platelets

37
Q

Once platelet is activated, there is a formation of what

A

Pseudopods/Filopodia

38
Q

Same size with RBC, premature release and increased demand

A

Giant Platelet

39
Q

If there would be an increased presence of giant platelets, it would result to

A

Falsely elevated RBC count

40
Q

Immature platelets can be seen in

A

Acute Megakaryocytic Leukemia

41
Q

Appear in compensation for thrombocytopenia

A

Stress Platelets

42
Q

If there is a decreased platelets in the circulation, the bone marrow will

A

Increase the production of megakaryocytes

43
Q

Located centrally and is granular

A

Chromomere/Granulomere

44
Q

Surrounds the chromomere/platelets and is nongranular or clear to light blue

A

Hyalomere

45
Q

Chromomere/Granulomere contains

A

Alpha granules and glycogen granules

46
Q

Carry the receptors for important function of the platelets

A

Glycoprotein structure

47
Q

Serves as site of arachidonic acid synthesis or pathway

A

Phosphatidylinositol

48
Q

Responsible for the formation of prostaglandin and thromboxane

A

Arachidonic acid

49
Q

Receptors that responds to cellular and humoral stimuli

A

Ligadns/Agonist

50
Q

Exterior coat with glycoprotein receptor sites

A

Glycocalyx

51
Q

An integrin that binds the subendothelial collagen promoting adhesion of the platelets

A

Gp Ia/IIa

52
Q

Collagen binder receptor and member of the immunoglobin gene family

A

Gp VI

53
Q

Receptor that also binds the adhesive protein thrombospondin

A

Gp IV

54
Q

Can cross the platelet membrane and interact with acting-binding protein

A

Gp IbB

55
Q

Binds fibrinogen

A

Gp IIb/IIa

56
Q

Generating interplatelet cohesion

A

Gp IIb/IIIIIa

57
Q

Anchors plasma membrane Gp and proteoglycans

A

Microfilaments

HEMA II LEC (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions