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HEMA II LEC > HEMA 2 LECTURE > Flashcards

HEMA 2 LECTURE Flashcards

1
Q

What quantitative WBC disorder is hairy cell
related to?

A

MONOCYTOPENIA

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2
Q

Aside from hairy cell, what viral disorder decreases monocytes?

A

Epstein-Barr virus

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3
Q

What if there will be obstruction in the lymphatic circulation, what WBC quantitative disorder is expected?

A

LYMPHOCYTOPENIA

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4
Q

Pertussis Infection

A

LYMPHOCYTOSIS

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5
Q

Protozoal Infection

A
  • MONOCYTOSIS
  • NEUTROPHILIA
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6
Q

After BM failure recovery

A

MONOCYTOSIS

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7
Q

Steroid therapy

A
  • NEUTROPHILIA
  • MONOCYTOPENIA
  • EOSINOPENIA
  • BASOPENIA
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8
Q

Physical Activity

A

NEUTROPHILIA

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9
Q

Overwhelming Infection

A

NEUTROPENIA

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10
Q

Hookworm infection

A

EOSINOPHILIA

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11
Q

Exposure to drug and allergens

A
  • BASOPHILIA
  • EOSINOPHILIA
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12
Q

LAP result in leukemoid reaction

A

INCREASED LAP

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13
Q

Decreased LAP score

A

CGL / CML

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14
Q

Leukoerythroblastic reaction can be present in what MPN?

A

Primary myelofibrosis

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15
Q

Disorder if there is absence of cell surface adhesion protein in WBC

A

LAD (Leukocyte Adhesion Deficiency)

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16
Q

Formation of large dark granules, associated with mucopolysaccharidosis

A

Alder-Reilly Anomaly

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17
Q

Giant granules of the cytoplasm of WBC

A

Chediak Higashi

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18
Q

Disorder representing bilobed neutrophil with dark staining nuclei

A
  • Pelger-Huet Anomaly
  • Other name: Neutrophil
  • Hyposegmentation
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19
Q

Enzyme released by eosinophil to form charcot-leyden crystals

A

LYSOPHOSPHOLIPASE

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20
Q

Term wherein WBC release content of granules

A

DEGRANULATION

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21
Q

Type of neutrophilia with redistribution of marginated granulocyte pool to circulating granulocyte pool; occurs 20-30 minutes

A

IMMEDIATE NEUTROPHILIA

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22
Q

Type of cells expected to see with “shift to the left”

A
  • BLASTS / BANDS
  • IMMATURE CELLS
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23
Q

Expected description of BM with high M:E Ratio

A
  • HYPERPLASIA
  • HYPERCELLULAR
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24
Q

Condition in which granulocytes cannot be released front the bone marrow

A

MYELOKATHEXIS

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25
Q

Neutrophil precursors undergoing selective apoptotic death in newborns

A

KOSTMANN’S SYNDROME

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26
Q

Other term for Kostmann’s Syndrome

A
  • INFANTILE GENETIC AGRANULOCYTOSIS
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27
Q

WBC to increase in agranulocytosis

A

Agranulocytes : mono and lympho

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28
Q

Between Job’s and Lazy Syndrome. Both random and directional motility impaired

A

Lazy Syndrome

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29
Q

Job’s Syndrome, what is impaired

A

Directional motility

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30
Q

Condition with strong oxidant deficiency

A

Myeloperoxidase deficiency

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31
Q

Replacement of BM cells by malignant cells

A
  • Primary myelofibrosis
  • MMM
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32
Q

WBC with Dohle inclusion in cytoplasm and presence of giant platelets

A

May Hegglin Anomaly

33
Q

No dohle inclusion body with presence of giant platelets

A

Bernard Soulier disease

34
Q

Deficient in enzyme glucocerebrosidase

A

GAUCHER DISEASE

35
Q

Enzyme deficient in Niemann Pick disease

A

Sphingomyelinase

36
Q

Specific WBC that serves as hallmark of megaloblastic anemia

A
  • Hypersegmented neutrophil
  • Neutrophil Hypersegmentation
37
Q

Giant brown granules resulting to impaired bactericidal activity

A

Chediak Higashi

38
Q

Cells / lineage involved with primary myelofibrosis. (increase)

A

Granulocytes and megakaryocytes

39
Q

Primary myelofibrosis. Expected mutated gene

A

JAK2, MPL, CLA-R

40
Q

Aside from myelofibrosis, what MPN also has 3 mutation

A

Essential thrombocytopenia

41
Q

Predominant cell increased in polycythemia vera

A

Erythrocytes

42
Q

In PCV, 90-95 % patients will have this mutation

A

JAK2V617F

43
Q

Acute lymphobasltic leukemia, L1

A

Small homogenous lymphoblast

44
Q

Is your L3 the same with Burkitt’s Lymphoma?

A
  • NAUR!
  • Burkitt’s Lymphoma: mature cells
  • L3: “burkitt type” only, lymphoblasts
45
Q

Where does Burkitt’s Lymphoma belong, Hodgkin
or Non-Hodgkin?

A

Non-Hodgkin’s Lymphoma

46
Q

L3. expected appearance of cells

A

Both nucleus and cytoplasm have VACUOLES

47
Q

Multiple myeloma

A

Plasma cells

48
Q

Non-hodkin’s lymphoma. What type of cells can be seen?

A
  • B-lymphocytes with normal morphology
  • Neoplasmic cell
49
Q

M7

A

Megakaryoblast

50
Q

M5a

A
  • “Schilling’s Leukemia”
  • Monoblast, immature cells
51
Q

M2

A

Myeloblast with granulocytes

52
Q

Start appearance of auer rods

A

M1

53
Q

M4Eo

A

Myelomonocytes and Eosinophils

54
Q

DIC

A

M3 (Hypergranular)

55
Q

Type of leukemia with myelocyte cells usually mature stages

A

Chronic

56
Q

Condition with predominantly mature cells involved

A
  • MPN (MYELOPROLIFERATIVE NEOPLASM)
57
Q

Cytopenia, ineffective hematopoeisis, increased apoptosis

A
  • Dysplasia
  • MDS
58
Q

Type of mutation occurring in chromosomes

A

Somatic mutation

59
Q

Diagnosis for AML. what is the basis of WHO?

A
  • > 20% blasts
  • FAD: >30%
60
Q

Malignancy with fusion of BCR-ABL region of chromosome

A

CML / CGL

61
Q

BCR-ABL is what type of chromosome?

A
  • Philadelphia chromosome
  • Translocation between the long arms of
    chromosome 9 and 22
62
Q

Chronic / Acute. Both blast and mature cells
involved

A

Acute

63
Q

Myeloproliferative disorder with increased
granulocytes (neu, baso, eo)

A

CGL / CML

64
Q

Expected EPO level with primary polycthemia

A
  • Decreased or normal
  • Other name: Osler’s or polycythemia rubra vera
  • Malignant - does not respond to level of EPO
  • If secondary - increased
65
Q

Two inclusion in cells involved in AML

A
  • Auer rods
  • Phi bodies
66
Q

AMLs with presence of Auer rods

A

M1, M2, M3m/v, M6

67
Q

Other term for acute erythroleukemia

A
  • Di guglielmo leukemia
  • M6
68
Q

Type of AML with high platelet

A

M7

69
Q

L1, L2, L3 increase with

A
  • Age and severity
  • Homogenous / heterogenous: morphology
70
Q

Lymphocytosis with smudge cells

A

CLL

71
Q

Predominant chromatin pattern of smudge cell

A

Soccer ball ; cobblestone appearance

72
Q

How can we stain hairy cells

A

TRAP

73
Q

Morphology of BM with many hairy cells

A

Fried egg appearance

74
Q

BM sample collection (hairy cells)

A

Dry tap

75
Q

Between AML and ALL. which is more common in children

A

ALL

76
Q

Lymphocytes with folded/ cerebriform nucleus

A
  • Mycosis Fungoides / Sezary Syndrome
  • Mycosis fungoides: benign, cutaneous
  • Sezary Syndrome: malignant, systemic
77
Q

Neoplastic cell involved in Hodgkin’s lymphoma

A

Reed sternberg cell

78
Q

Correlation between increased ESR in multiple
myeloma

A

Ig in plasma cell → ↓ zeta potential (less -
charge) → rouleaux formation → ↑ ESR

HEMA II LEC (6 decks)

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