Module 3 Flashcards
integrin
major transmembrane protein allowing a cell to attach to the ECM
laminin
extracellular adhesive/attachment
glycoprotein
cross shaped molecule with several binding domains
lamin
structural protein found in nucleus
collagen
ECM structural support, high or low as needed by tissue
most abundant protein in body
fibronectin
adhesive/attachment
proteoglycans
protein polysaccharide complexes consisting of core protein strand with polysaccharide attachments
space filling, resist compression and provide cushion
acidic (sulfate groups) bind to cations and water
talin
attaches integrin to the actin cytoskeleton
key regulator of the communication between the actin cytoskeleton and the ECM
vinculin
attaches integrin to the actin cytoskeleton
key player in cell-matrix and cell-cell adhesions that build a strong physical connection for transmitting forces between the cytoskeleton, the extracellular matrix, and cell-cell connections
paxilin
protein
interact w talin and FAk
sends signals to nucleus
selectins
relys on calcium dependent binding
lectins
allows selectin to recognize a particular sugar moiety
focal adhesion kinase
groups of integrins form this contact point for adhesion
cadherins
glycoprotein that adheres cells together in the transmembrane
calcium dependent
tissue specific
catenins
alpha and beta involved in adheres junctions
IgCAMs
immunoglobulin family of cell adhesion molecules
proteins that bind to one another and some other adhesion molecules
calcium independent binding
plectin
protein that forms cross bridge with intermediate filaments for structure
Hemidesmosome
nexin
forms a bridge to link doublets (a and B tubules) together in flagella structure
actin
helical protein filament formed by polymerization of globular actin molecules
actinin
BP180
used in hemidesmosome
specialized adhesion protein
claudin
involved in tight junctions
paired with other proteins to form a barrier
occludin
tight junctions
ZO proteins adhesion proteins work with claudin on joining cell
in tissue
ZOs
cytosolic adhesion modules
JAMs
transmembrane protein used in tight jxns
microfilaments
solid filaments involved in contraction
microtubule
rigid tubes providing internal cellular support
heterodimer formed from alpha and beta tubulin, 13 heterodimer orient in circular fashion
cofilin
destabilize F-actin
profilin
appears to accelerate polymerization
F-actin
tropomyosin
fits in grooves of actin filament during contraction to allow binding with myosin
troponin
control of calcium binding
prevents binding when muscles fatigued, prevents actin-myosin interaction and occurs when calcium depleted in cell environment
Z-disk
actin and myosin can create a structural link to z-disk through anchoring structures
end of sarcomere