Module 2.2 Flashcards
THe dominant trait is always expressed
Dominant allele cannot completely mask effect of recessive allele so it blends
Non-mendelian inheritance both alleles are equally dominant
This dominance where a heterozygote has more extreme phenotype than its parents
Complete dominance
Incomplete dominance
co dominance
Overdominance
Autosomal dominant diseases (4)
Huntington’s disease
achondroplasia (dwarfism)
polycystic kidney disease
polydactyly
Autosomal recessive inheritance (4)
Cystic fibrosis
Tay-Sachs
Hemochromatosis
phenylketonuria (PKU)
Base letter of MN blood type L comes from who (2)
Landsteiner
Levine
Codominance disease/conditions (2)
Sickle cell anemia
ABO blood groups
Malaria causing disease that is cancelled by sickle cell
Plasmodium falciparum
Heterozygotes:
Cystic fibrosis
Thalassemia
Deafness
CYSTIC FIBROSIS
Cholera
Typhoid fever
THALASSEMIA
Malaria
DEAFNESS
Thicker Epidermis
THe I antigen in the blood type
isoagglutinogen
The Gene necessary to produce A and B antigens
Adds sugar frucose to substance
H Gene
T or F: Whenever inbreeding occurs the proportion of rare homozygotes increases in frequency
True
Group of people who would be incompatible when rossmatched with red cells of all normal ABO groups
Bombay
w/ h gene
T or F: lethal alleles only cause organism to die if it is heterozygous
F, it will die if homozygous
Genes that kill homozygous and heterozygous individuals
Genes that only handicap their possessor
Homozygote for allele is recessive
Completely lethal genes
subvital, sublethal
Recessive lethal genes
Lethal genes in flies (say scientific name)
Drosophila melanogaster
Curly wings
Plum eyes and stubble bristle
Has a gene lethal in homozygous state due to interfering with spinal development or just cause lack of tail
Manx cat
Recessive Lethal gene that is due to deficiency of hexo saminidase A
Inability to break down specific membrane lipids
Destroys nerve cells in brain and spinal cord
Motor skills lost
Exaggerated startle reaction
Other intellectual and physical disability
Tay-Sachs disease
Recessive Lethal gene condition that causes early death through 2 doses of a recessive allele
Sickle cell anemia
Dominant lethal gene, a progressive diorder callled ___. Appear usually at 30s or 40s, affects brain’s __ which is motor control, learning, emotional.
Increased blinking, abnormal eye movements, abnormal speech
Cognitive impairments
Depression
Huntington’s Disease
Conditional temperature sensitive lethal genes in flies (___) which kill larva at 30 C
Drosophila melanogaster
Conditional lethal gene in humans, if they consume fava they develop anemia. G6PD allele
Favism
Semi-lethal genes in humans that can impair the blood clotting, can only kill some individuals
Hemophilia
