Module 2 Unit 2: Liver Enzymes

Question 1

Group of enzymes that catalyze the interconversion of amino acids to 2-oxo-acids by transfer of amino groups

Answer 1

Aminotransferases

Question 2

Aspartate aminotransferase is also known as

Answer 2

Serum glutamate oxaloacetate transaminase

Question 3

Alanine aminotransferase was formerly called

Answer 3

Serum glutamate pyruvate transaminase

Question 4

TRUE or FALSE: Pyridoxamine-5’-phosphate and its amino acid analogue pyridoxal-5’-phosphate act as coenzymes in the amino-transfer reactions.

Answer 4

False; Pyridoxamine-5’-phosphate is the amino acid analogue of Pyridoxal-5’-phosphate

Question 5

Involved in the transfer of an amino group between aspartate and a-keto acids

Answer 5

Aspartate aminotransferase (AST)

Question 6

Catalyzes the transfer of an amino group from alanine to a-ketoglutarate with the formation of glutamate and pyruvate

Answer 6

Alanine aminotransferase (ALT)

Question 7

TRUE or FALSE: AST is completely extramitochondrial.

Answer 7

False; AST is both intra- and extramitochondrial

Question 8

AST is most commonly distributed in the _____ while ALT is found primarily in the _____.

Answer 8

Body tissues, Liver