Module 2 Sympatholytics

Question 1

Effects of Sympatholytics drugs:
A. Orthostatic Hypotension and Reflex bradycardia
B. Mydriasis
C. Tachycardia
D. All of the above

Answer 1

C

Question 2

These type of antagonist do not dissociate from receptors

Answer 2

Irreversible Antagonists

Question 3

Agonists that dissociate from receptors

Answer 3

Reversible Antagonists

Question 4

Which of the following is/are reversible antagonist?
A. Phentolamine
B. Prazosin
C. Terazosin
D. All of the above

Answer 4

D

Question 5

An irreversible alpha-1 antagonist

Answer 5

Phenoxybenzamine

Question 6

What is the adverse effect of an irreversible alpha1 antagonist?
A. Bradycardia
B. Hypertension
C. Erectile dysfunction
D. Inhibition of ejaculation

Answer 6

D (Parasympa: erection - sympa: ejaculation)

Question 7

This drug is a competitive antagonist to both alpha 1 and alpha 2 receptors.

Answer 7

Phentolamine

Question 8

What drug/s may be used for the treatment of pheochromocytoma?

Answer 8

Phenoxybenzamine / Phentolamine

Question 9

What receptor/s is/are blocked by phenoxybenzamine?

Answer 9

Histamine (H1), ACh, and serotonin receptors

Question 10

This drug is higly selective for alpha-1 receptors

Answer 10

Prazosin

Question 11

What is the treatment of choice for BPH? This drug has a high bioavailablity. 
A. Prazosin
B. Terazosin
C. Tamsulosin
D. Doxazosin

Answer 11

C

Question 12

Which among the alpha receptor antagonist drugs has the longest half-life?

Answer 12

Doxasozin (22-hrs)

Question 13

This drug is extensively metabolized in the liver

Answer 13

Terazosin and Tamsulosin

Question 14

A pt presents with HPN, headache, palpitations, and increased sweating. Furthers tests showed that the pt has a tumor in the adrenal medulla. What drug should you give for preoperative managemnt pf the disease?

Answer 14

Phenoxybenzamine - tx for pheochromocytoma (excess catechilamines)

Question 15

This drug inhibits tyrosine hydroxylase. What is this drug and its side effect?

Answer 15

Metyrosine - extrapyramidal side effects (due decreased dopamine)

Question 16

What drug is efficacious in the treatment of mild to moderate systemic HPN?

Answer 16

Prazosin

Question 17

Which of the following is/are the effects of beta receptor antagonist drugs?
A. Positive inotropism and chronotropism
B. Negative inotropism and chronotropism
C. Increased IOP
D. Decreased VLDL

Answer 17

B. (Others kabaligtaran)

Question 18

These drugs have good oral absorption, low availability, and with rapid distribution.

Answer 18

Beta receptor antagonist drugs

Question 19

Which among the beta receptor antagonist drigs undergoes extensive hepatic metabolism?

Answer 19

Propanolol

Question 20

This drug is the prototype beta blocker

Answer 20

Propanolol

Question 21

Which among the beta receptor antagonists is similar to Doxasozin in terms of its half-life?

Answer 21

Nadolol (24hrs)

Question 22

What is/are the beta blockers that can cross the BBB?

Answer 22

Propranolol and Penbutolol

Question 23

What is the effect of beta blockers in the CVS?

Answer 23

Negative inotropism and chronotropism, increase peripheral resistance

Question 24

Which among the beta blockers are cardioselective?

Answer 24

Metoprolol, Atenolol

Question 25

``` Which of the ff is the effect of beta blockers in the eye? A. Decreased aqueous humor B. Decreased IOP C. Tx for glaucoma D. All of the above ```

Answer 25

D

Question 26

What is the metabolic and endocrine effect of beta blockers?

Answer 26

Inhibition of lipolysis and glucogenolysis, increased VLDL and decreased HDL

Question 27

What beta blocker is the choice in COPD patients?

Answer 27

Metoprolol and atenelol

Question 28

This beta blocker is highly selective to beta-1

Answer 28

Nevibolol

Question 29

This drug has a similar action with timolol

Answer 29

Nadolol

Question 30

``` Which among the beta blockers is the treatment of choice for glaucoma? A. Nadolol B. Timolol C. Levobunolol D. Betaxolol ```

Answer 30

B

Question 31

These drugs have partial beta agonist activity amd is used for HPN and angina

Answer 31

PAC-BOx-CP | Pindolol, Acebutolol, Carteolol, Bopindolol, Oxprenelol, Celiprolol, Penbutolol

Question 32

This drug is a potent alpha and beta blocker

Answer 32

Labetalol

Question 33

Which among the beta blockers is an ultra short acting beta 1 selective blocker?

Answer 33

Esmolol

Question 34

What is the most common adverse effect pf beta blockers?

Answer 34

Bradycardia

Question 35

What is the metabolic adverse effect of beta blockers?

Answer 35

Hypoglycemia

Question 36

Which among the beta blockers may be used for the treatment ofstage fright and alcohol withdrawal?

Answer 36

Propanolol

Question 37

Which among the beta blockers is/are effective in reducing mortality in patients with CHF?

Answer 37

Metoprolol, Bisoprolol, Carvedilol

Question 38

``` Which of the following is an effect of beta blockers? A. Reduce ventricular ectopic beats B. Blocks adenoreceptors C. Inhibits coversion of T4 to T3 D. All of the above ```

Answer 38

D

Question 39

What beta blockers are used for the treatment of glaucoma

Answer 39

Betaxolol, Carteolol, Levobunolol, Metipranolol

Question 40

TRUE or FALSE: Beta blockers increase the frequency of anginal episodes

Answer 40

False (reduce dapat)

Question 41

What other drugs is often used in conjunction with beta blockers?

Answer 41

Diuretics and vasodilators