Module 2- general info Flashcards
types of antibiotic therapy
empiric, definitive, prophylactic, therapeutic, subtherapeutic, superinfection
types of bacteria
bacilli- rod
cocci-round
gram -
gram +
gram + bacteria
2 layer cell wall that is easy to penetrate
gram - bacteria
3 layer cell wall = more difficult to penetrate
mycobacterium
special bacteria, waxy cell wall, harder to kill
mycobacterium tuberculosis-
virus characteristics
reproduce inside cell
=effort to kill virus usually toxic to host
antibiotics are ineffective
fungi characteristics
plant like organisms that don’t need to survive
primary fx is to eat dead tissue
treat with antifungals
parasite characteristics
may live in host cells, organs, structures
helminths
worms that live in intestines
example of parasitic infection
malaria
aerobic bacteria
require oxygen to survive
aerobic bacteria usually found in
mouth, GI, lungs
anaerobic bacteria
don’t need oxygen to survive
example of anaerobic
gangrene caused by clostridium perfringes
types of bacteria antibiotics
bactericidal and bacteriostatic
bactericidal antibiotics
kills bacteria directly by:
weakened cell wall =open and lyse
bind to ribosomes and dec. protein synthesis depleting replication; or kill directly
bacteriostatic antibiotics
interfere w/ bacteria replication -> slows protein synthesis= gradually decreasing number of bacteria in system allowing immune system to kill remaining
which antibiotics are beta lactams
penicillin’s and cephalosporines
what type of antibiotics can cause antibiotic resistance?
broad spectrum antibiotics
disinfectant
often kill organisms, only used on non-living objects
bactericidal
antiseptic
applied to living tissue,
bacteriostatic
antiretroviral therapy (ART)
reduces replication of HIV
interfere w/ life cycle of HIV retrovirus
types of antiretroviral drugs
viral entry blockers
enzyme inhibitors
viral entry blockers kinds
entry fusions inhibitors and CCR5 inhibitors
entry fusion inhibitors
inhibit HIV disease that is advanced or resistant
CCR5 antagonists
treat only HIV 1 which binds to CCR5- blocks fusions of HIV to CD4 cells
enzyme inhibitors
nucleoside transcriptase inhibitors, integrase inhibitors, protease inhibitors
viral replication
viruses can not replicate on own, must be attached and enter host cell (called fusion)
viruses can enter body through 4 routes
inhalation to resp tract, ingestion GI tract, transplacental, inoculation- skin mucous membranes
antitubercular drugs
reduce cough to reduce infectiousness
reduce s/s
antifungal drug therapy treats
yeasts, molds
yeasts
single celled fungus, reproduce by budding
molds
multi- cellular, characterized by long, branching filaments (hyphae)
HIV characteristics
intracellular parasitic virus, has genetic material used to reproduce in form of RNA rather than DNA
attacks CD-4 cells that play role in immune system
2 forms of HIV
HIV 1 (worldwide) HIV2 (common in west africa) and develops more slowly
phases of retrovirus
- attachment/binding
- uncoating and fusion
- DNA synthesis
- integration
- transcription
- translation
- cleavage
- budding