Module 12-14 Flashcards
Petechiae
small red purpura or bruises that result from leakage from capilaries. They are less than 3mm in diameter. Prominent in extremeties d
Ecchymoses
Brusies larger than a centimeter usually caused by leakage from a blood vessel larger than a capillary. Red or purple and become yellow green as they heal.
Hematoma
Formed when blood leaks through a vessel and collects beneath the skin. Can occur in any organ. Color is blue or yellow, and area is slightly raised. Commonly called a bruise and is often the result of some sort of trauma including surgery.
Epistaxis
Nose bleed. Common in hemostatic defects of platelets. Can be caused by trauma or pathophysiology.
ITP
Immune thrombocytopenia. Destruction of platelets due to autoimmune Ab, and / or loss of self tolerance by CTLs or Tregs. Present only with thrombocytopenia, and due to difficulty in detecting platelet Ab diagnosis is typically made by exclusion. Treated with corticosteroids and IVIG.
DIC
Disseminated intravascular coagulopathy. Can be caused by sepsis, tumors / leukemias, trauma, transfusion and allergic reactions. Systemic coagulation and consumtion of clotting factors especially prothrombin. Can cause fatal bleeding and sometimes thrombosis.
consumption coagulopathy
A term sometimes used interchangeably with DIC, but which refers to the consumption of several clotting proteins and their inhibitors faster than they can be synthesized by the body, leading to a deficiency. This process explains the bleeding seen in DIC patients when systemic coagulation occurs in response to sepsis tumors and leukemia, burns, and trauma among others.
Acute phase protein:
These are proteins in the plasma which increase or decrease in response to inflammation. Some positive acute phase proteins are MBL, CRp, alpha 2 macroglobuilin (plasmin and thrombin inhibitor) ferritin, hepcidin, and haptoglobin. Negative acute phase proteins include albumin, transferrin, and antithrombin, and typically conserve energy and amino acids for the production of the positive phase proteins which combat inflammation.
screening testing
Screening tests measure secondary hemostasis and include the PT, APTT, TT, and quantitative fibrinogen test. These tests are cheap and easy to perform, and collectively cover a large portion of secondary hemostasis and are thus a good starting point for further reflexive testing
PPP
Platelet poor plasma or plasma with a platelet count of less than 10,000 per microliter. Obtained by spinning citrated blood at a low speed for 10-15 minutes. Useful for coagulation studies which requires some but not full amounts of platelets
Demarcation membrane system:
Internal membrane system not visible by light microscopy found in developing megakaryocytes. The system is composed of invaginations of the cytoplasmic membrane which aid in extracellular communication and eventually become the membrane of newly formed platelets.
endomitosis
Doubling of a cells DNA without nuclear or cytoplasmic division. In megakaryocytes it begins in the blast stage and is completed by phase II; can be 4N to 64N.
open canicular system
Channels leading from surface to interior which are formed from plasma membrane invaginations. Is the route of entry of external substances, exit route for granules, and provides extra membrane during platelet activation and shape change.
TUNNICA INTIMA
The innermost layer of endothelial tissue in consisting of one layer of vascular endothelial cells surrounded by a basement membrane and subendothelial connective tissue. VECs synthesize and secrete many of the signaling molecules responsible for maintaining hemostasis and initiating clot formation.
TUNICA MEDIA
Middle layer of endothelial tissue which is thicker in arteries than in veins which helps in blood pressure regulation. Consists of smooth muscle cells, and loose connective tissue composed of collagen, reticular fibers, and proteoglycans.
