Hematopoeisis

Question 1

Fetal hema place

Answer 1

yold sac

Question 2

hema place after birgh

Answer 2

yolk sac agm, fetal liver, then marrow

Question 3

stem progenitor cell %

Question 4

asymmetric cell division

Answer 4

one daughter cell becomes progenitor other remains stem cell

Question 5

unipotential

Answer 5

committed to one pathway

Question 6

stem and progenitor cell identification

Answer 6

no distinguish morphologically, only through clonal assays

Question 7

LT and ST HSC

Answer 7

Transplantation studies in lethally irradiated mice: LT takes longer, but can give rise to more.

Question 8

CD34

Answer 8

common marker for stem and progenitor cells, except CFUEMk

Question 9

EPO produced where>

Answer 9

Kidney,

Question 10

Hematopoeisis in long bones

Answer 10

absent after age 25 except in proximal ends

Question 11

STEM CELL PROPERTIES

Answer 11

multipotential, high self renewal capacity

Question 12

Stem cell phenotypse (+)

Answer 12

CD34, tHY+, cd49 f+

Question 13

STEM CELL NICHE

Answer 13

OSTEOBLASTIC NICHE SUPPORTS AND MAINTAINS, QUIESCNENCE OR SELF RENEWAL. VASCULAR NICHE PROVIDES SIGNALS.

Question 14

Growth factor functions

Answer 14

produced by stromal cells. Multpiple biological activity (pleotrophic), redundancy, INTERPLAY OF SEVERAL GFS OFTEN INVOLVED, INTERACT WITH MEMBRANE RECEPTORS, COMMONLY ACT SYNERGISTICALLY, PROMOTE SURVIVAL AND DIFFERENTIATION.

Question 15

early acting growth factors

Answer 15

SCF, FL, IL-3, GM-CSF, IL-6, and IL-11.

Question 16

scf

Answer 16

suppresses apoptosis of HSCs and promotes the proliferation and differentiation of stem cells, multilineage progenitor cells, and some committed progenitor cells (CFU-GEMM, GMP, CFU-Mk, BFU-E).

Question 17

FL

Answer 17

(FL) increases recruitment of primitive HSCs/HPCs into cell cycle and inhibits apoptosis.

McKenzie, Shirlyn B.; Williams, Lynne. Clinical Laboratory Hematology (3rd Edition) (Pearson Clinical Laboratory Science Series) (Page 47). Prentice Hall. Kindle Edition.