Module 11: Nutrition and Its Role Flashcards

1
Q

What were the Canadian Cardiovascular Society’s 4 Recommendations for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease? Describe each.

A

1) Adopt healthy eating habits
- Limit intake of saturated fat and trans fatty acids, simple sugars, refined carbohydrates
- Emphasize a diet rich in vegetables, fruit, whole-grain cereals, and polyunsaturated and monounsaturated oils, including omega-3 fatty acids

2) Achieve and maintain a healthy weight
- Waist circumference: <94cm males, <80cm females

3) BMI <27 as a minimum goal
- optimally <25

4) Engage in regular physical activity
- 60 min light
- 30-60 min moderate
- 20-30 min of vigorous activity
- 4-7days/week

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2
Q

Describe the guidelines developed by the National Cholesterol Education Program (NCEP), Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (ATP-III) to reduce LDL-cholesterol

A

1) Total fat 25 - 35% of total calories

2) Saturated fats <7% of total calories
- Minimize saturated and trans fat (bad fats); encourage small amounts (2-3 Tbsp) of unsaturated fats (good fats)
- 5-70 total grams fat/day
- 11-17 grams of saturated fat/day

3) Dietary cholesterol <200 mg per day
4) Total fibre 20 - 30 g per day

5) plus LDL-lowering therapeutic options
- Plant stanols/sterols (2 g per day)
- Viscous (soluble) fiber (10–25 g per day)

6) Weight reduction
7) Increased physical activity

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3
Q

What are sources of saturated fat?

A
  • solid fat that comes from animal sources, like the skin on chicken, the marbling in steak, the white part of bacon and the fat in milk, cream, and cheese, and in certain types of processed foods that contain fully hydrogenated vegetable oil
  • commonly found in meat and dairy products.
    commonly found in coconut and palm oils.
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4
Q

What is the principal dietary determinant of LDL levels?

A

Saturated fats

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5
Q

What are the 4 most common saturated fatty acids in the human diet

A

Lauric, myristic, palmitic, and stearic acids

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6
Q

Calculate the recommended total fat and saturated fat and mono poly unsaturated fatty acids for a diet of

1) 1500kcal
2) 1600kcal
3) 1800kcal
4) 2200kcal

A
1) 1500kcal
Fat (30%) = 450kcal / 9 = 50grams
Saturated fat (7%) = 105kcal / 9 = ~11 grams
Mono PUFA grams = 39
- 1 tsp = 4g fat = 36kcal (1g = 9kcal)
2) 1600kcal
Fat (30%) = 450kcal / 9 = 50grams
Saturated fat (7%) = 105kcal / 9 = ~11 grams
Mono PUFA grams = 39
3) 1800kcal
Fat (30%) = 450kcal / 9 = 50grams
Saturated fat (7%) = 105kcal / 9 = ~11 grams
Mono PUFA grams = 39
4) 2200kcal
Fat (30%) = 450kcal / 9 = 50grams
Saturated fat (7%) = 105kcal / 9 = ~11 grams
Mono PUFA grams = 39
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7
Q

How do trans fat affect the different and total cholesterol?

A
  • raise the total and LDL cholesterol and lower HDL cholesterol.
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8
Q

How are trans fat produced?

A
  • chemically produced trans-unsaturated fatty acids.

- formed when oils are partially hydrogenated and end up behaving much more like saturated fat

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9
Q

Examples of where to find trans fat?

A

some trans fatty acids occur naturally (like in milk and meat), the majority come from baked goods, fast foods, snack foods, some hard or stick margarines, and shortening

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10
Q

Trans fatty acids are:

  • formed when ____ are converted to _____. thru a Process known as _______.
  • the Down regulate ______.
  • also decreases ______.
  • found in processed foods such as ________.
A

Trans fatty acids are:

  • formed when liquid oils are converted to solid fats. thru a Process known as hydrogenation.
  • the Down regulate LDL receptors.
  • also decreases HDL.
  • found in processed foods such as baked goods, chips, cookies.
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11
Q

Even when calories remain the same between diets, by substituting either _____ or _____ fat for _____ fat can reduce serum LDL cholesterol

A

Even when calories remain the same between diets, by substituting either MONOUNSATURATED or POLYUNSATURATED fat for SATURATED fat can reduce serum LDL cholesterol

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12
Q

Example of foods that are high in monounsaturated fats

A

1) Olive oil, Canola oil
2) Avocado
3) Oleic acid - less prone to oxidation and does not decrease HDL
4) NUTS: “instead of” not in “addition to” WATCH PORTION (¼ cup)Poly

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13
Q

How can Polyunsaturated fats be divided?

A

omega-3 and omega-6

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14
Q

Example of 2 omega-3 fats and what food are they found in

A

Docosahexanoic (DHA) and eicosapentanoic (EPA) are types of omega-3 fat found in fatty fish like salmon, sardines, mackerel, and herring, and seafood – oysters

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15
Q

What is an omega-3 fat thats essential but the body can’t synthesize?

A

Alpha linolenic acid

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16
Q

Sources of alpha linolenic acid?

A

flaxseed and flaxseed oil, canola and soybean oil, and some margarine and spreads made with these oils

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17
Q

What is Linoleic acid? Found in what food?

A
  • a type of omega-6 fat, is fairly common in the North American diet
  • vegetable oils, like corn, safflower, or soybean oil.
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18
Q

How does the Canadian Cardiovascular Society recommend to lower triglycerides and/or increase HDL-C

A
  • increase in the intake of omega-3 fatty acids

- also omega-6 intakes have been associated with cholesterol lowering

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19
Q

Polyunsaturated fats:

  • upregulate LDL by up regulating ______
  • PUFA intake relative to sat fat results in _____ ¯apo B production
  • Are _____ and _____ acids
  • Are _____ at room temperature
  • Found in _______
A

Polyunsaturated fats:

  • upregulate LDL by up regulating LDL RECEPTORS
  • PUFA intake relative to sat fat results in DECREASED ¯apo B production
  • Are LINOLEIC and LINOLENIC acids
  • Are LIQUID at room temperature
  • Found in SAFFLOWER, SUNFLOWER, CORN, AND SOYBEAN OILS
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20
Q

What are the dietary recommendations on how to inc omega-3 FAs?

A

Increase n-3 fatty acids:

1) Eat fish 2-3x/wk
- Salmon, mackerel, sardines and herring
- Contains eicosapentanoic acid (20:5n-3, EPA)
docosahexanoic acid (22:6n-3, DHA)

2 )Plants: (flaxseed, canola, soybeans):

  • alpha-linolenic acid (18;3n-3, LNA)
  • not as biologically efficient as EPA and DHA
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21
Q

How does omega 3 reduce cardiac risk?

A

modifying thrombogenesis, arrhythmia, serum lipids, endothelial function, hypertension and decrease inflammation

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22
Q

When is Fish oil supplements on a routine basis beneficial?

A

in some patients with very high triglyceride levels (7% decrease for every 1g of fish oil)

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23
Q

Example of foods high in cholesterol?

A
  • shrimp
  • egg
  • liver
  • cheese
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24
Q

What are the dietary recommendations for high cholesterol food?

A

Animal products only (< 200 mg cholesterol/day)

  • Limit to 2 egg yolks/wk
  • Limit to 4-6oz of meat, poultry and fish/day
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25
Q

Cholesterol is:

  • Only found in _____ products.
  • LDL but less than _____ fat.
  • _____regulates LDL receptors.
  • Response is _____.
  • ____ content of diet.
  • presence of other _____.
  • ______ of an individual to dietary cholesterol.
  • lipid profile and ____ status.
A

Cholesterol is:

  • Only found in ANIMAL products.
  • LDL but less than SATURATED fat.
  • DOWNregulates LDL receptors.
  • Response is VARIABLE.
  • FA content of diet.
  • presence of other STEROLS.
  • SENSITIVITY of an individual to dietary cholesterol.
  • lipid profile and DIABETIC status.
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26
Q

What are the Dietary recommendations for carbs?

A

1) Limit simple sugars and refined carbohydrates as follows:
355ml pop = 10 tsp of sugar (156kcal)
250ml apple juice = 7.4tsp of sugar (119kcal)
500ml Gatorade = 8 tsp of sugar (127kcal)
2tsp of sugar in 4c coffee/day =8tsp (128kcal)
Mocha frappuccino tall, no whipped cream = 10tsp (200kcal)
1tsp=4g sugar=16kcal

2) Distribute carbs evenly throughout the day
3) Eat regular meals and snacks!

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27
Q

Benefit of insoluble vs. soluble fiber?

A

Insoluble fibre increases gastrointestinal motility and reducing mechanical problems such as hemorrhoids, constipation, diverticulosis and possibly colorectal cancer vs. soluble fibre may lower blood cholesterol levels and may reduce the risk of heart disease.

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28
Q

Examples of soluble fibre?

A

atype of non-digestible carb that is found in foods like oatmeal, beans, apples, and pears

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29
Q

How do soluble fibre lower blood cholesterol?

A

binding with cholesterol in the SI and carrying it to the LI for removal

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30
Q

Example of insoluble fibre?

A

wheat bran, whole grains, peas, root vegetables and strawberry seeds

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31
Q

Why is fibre called soluble/insoluble?

A

Soluble fibre components are soluble in water

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32
Q

What is Canada’s Food Guide recommendation for fibre?

A

1) Choose whole-grain, high-fibre foods
2) Aim for 21-38 grams fiber/day
3) Aim for 10-25 grams of viscous (soluble fiber) /day
4) Soluble fiber – oats, beans, lentils, barley, and psyllium, some fruits and vegetables, pectin
5) Insoluble fiber – wheat bran, whole grain foods, skins/seeds, nuts and nut butters, fruits and vegetables

33
Q

How does fibre dec LDL conc

A
  • Bind to bile acids during formation of micelles

- bile acid excretion and up regulate LDL receptors

34
Q

Example of a food with fibre (say serving size of food, amount of soluble fibre per serving, and total fibre per serving)

A

1 medium apple
soluble fibre/serving: 1.0g
total fibre/serving: 3.5g

35
Q

for every ____ serving/day increase in fruits and vegetable intake, there was a ____% lower risk of CHD

A

for every 1 serving/day increase in fruits and vegetable intake, there was a 4% lower risk of CHD

36
Q

What specific components of fruits and vegetables are heart-healthy?

A
  • potassium, and decreased blood pressure
  • folate and reduced homocysteine
  • Include sources of micronutrients such as antioxidants, folic acid and phytosterols
37
Q

What are the recommendations for alcohol?

A
  • No more than 2 drinks per day for males and 1 drink per day for females
  • People with high TGs should minimize alcohol intake
38
Q

Why might light-to-moderate consumption may be associated with a reduced risk for developing coronary heart disease and ischemic stroke?

A

alcohol induced changes may occur in serum lipids, lipoproteins, blood clotting proteins and may increase HDL cholesterol

39
Q

How can diets work (in the prevention and treatment of CVD)?

A

Diet can modify:
1) Lipid concentrations
by affecting cholesterol absorption, chylomicron and VLDL production, and regulation of LDL receptors
2) Progression of CVD by affecting oxidation of LDL cholesterol, thrombogenesis, and LDL particle size

40
Q

What dietary factors, which affect lipid concentrations, should be modified? How do they affect lipid conc?

A

Factors which affect lipid concentrations:

1) Total fat
- inc serum cholesterol and TGs by increasing chylomicron and/or VLDL production

2) Saturated fat (C12, C14, C16)
- inc LDL cholesterol by down regulating LDL receptors

3) Trans fatty acids (C18:1 trans)
- Avg consumption: 5.3 grams per day in U.S.
- Increases serum total and LDL-cholesterol (Lesser extent than saturated fat)
- May decrease HDL-cholesterol

4) Mono and polyunsaturated fatty acids:
- Reduces LDL cholesterol when substituted for saturated fats by up regulating LDL receptors
- Increase PUFA intake relative to saturated fat results in a decrease in apo B production

5) Dietary cholesterol
- Increases LDL cholesterol by down regulating LDL receptors –> Not to the same extent as saturated fat)
- -> Response is variable
- -> Fatty acid content of diet
- -> Presence of other sterols
- -> Sensitivity of an individual to dietary cholesterol
- -> Lipid profile and diabetic status

6) Excess calories, excess refined carbohydrates, binge eating
- Increases TGs by increasing VLDL production

7) Low fat, high sugar diet, binge eating
- Affects progression of CVD
- May contribute to metabolic syndrome
- -> Small dense LDL particles
- -> Hyperinsulinemia
- -> Abnormal glucose tolerance
- -> Increased abdominal circumference

8) Fibre, especially soluble fibre:
- Reduces LDL cholesterol by reducing cholesterol absorption, and increase bile acid excretion and up regulate LDL receptors
- Gel-forming fibres - pectin, oats, psyllium, guar gum may lower total and LDL-cholesterol
- small effect of soluble fibre within practical range of 2-10g/day
e. g. 3 g soluble fibre from 3 apples could decrease total cholesterol by approximately 0.13 mmol/L or 2%
- Insoluble fibre does not affect cholesterol, in the Nurse’s Health Study (highest vs lowest quintile) saw a 34% decrease in the risk of CVD.

9) Alcohol:
- Increases TGs by increasing VLDL production
- Increases HDL cholesterol in many individuals
- May decrease HDL cholesterol in those with high triglycerides

41
Q

What are 3 examples of phytosterols?

A

Sitosterol, campesterol, stigmasterol

42
Q

Phytosterols are structurally similar to?

A

Cholesterol

43
Q

Fxn of phytosterols?

A

Reduces absorption of cholesterol in gut

44
Q

Where are phytosterols found

A

plant foods especially with a high fat or fiber content (wheat germ, nuts, seeds, legumes, soybeans, vegetable oils)

45
Q

Dietary recommendation of phytosterols?

A

Diet – 100-400mg/day – range between 59-749mg/day

46
Q

relationship btwn antioxidants and CVD?

A

Clinical trials have failed to demonstrate a beneficial effect of antioxidant supplements on CVD morbidity and mortality.

47
Q

adverse effects of antioxidants?

A

1) HATS
2) Pts with known CVD and/or
3) on statin – are advised to d/c
4) vitamin E and C

48
Q

What are 3 examples of flavonoids

A

flavones, catechins, anthocyanins

49
Q

What foods are flavonoids found?

A
  • Present in fruits, vegetables, nuts and seeds

- > Main sources are tea, onions, soy, chocolate, wine

50
Q

Epidemiological studies suggest inverse relationship with coronary heart disease, possible mechanism?

A

1) act as antioxidants and inhibit oxidation of LDL

2) inhibit platelet aggregation

51
Q

Effect of a Mediterranean-Style Diet on Endothelial Dysfunction and Markers of Vascular Inflammation in the Metabolic Syndrome?

A

Patients consuming the intervention diet had significantly reduced serum concentrations of hs-CRP, decreased insulin resistance, and endothelial function score improved

52
Q

What is the DASH diet?

A

The DASH Diet based on 2 studies, DASH and DASH-Sodium, that looked at ways of reducing BP through changes in diet.

  • In DASH study, 3 eating plans: 1 similar in nutrients to what most North Americans eat; the same plan but with extra vegetables and fruit; or the DASH diet (rich in veggies, fruit, low-fat dairy foods, lower in saturated fat, total fat and cholesterol). Cutting total fat, sat fat, and cholesterol while upping FnV and low fat dairy means higher in K, Mg, Ca, and fibre. Alcohol was limited to 1-2 drinks/day. Na kept at 3000mg.
  • DASH diet decreased BP, results 5.5 point dec in systolic and 3 points for diastolic

In DASH-Sodium study, the 3 plans were combo diet with either 3,300, 2,300, or 1,500 mg Na (2/3 of a teaspoon of salt). Best results (greatest dec in BP) seen with 1500mg Na. People with HTN had the largest decrease in BP (11.5 vs. 7.1)

53
Q

The Evolution of Obesity: This is a common picture first demonstrated in Time Magazine.
This image depicts the evolution of our society: from the _____ to ______ individual.

A

The Evolution of Obesity: This is a common picture first demonstrated in Time Magazine.
This image depicts the evolution of our society: from the HUNTER GATHER to SEDENTARY individual.

54
Q

What is overweight vs obese?

A
  • Overweight = BMI ≥25 kg/m2

- Obese = BMI ≥30 kg/m2

55
Q

over ___% of the population in Saskatchewan and NWT are obese, while ____% of Ontario, Manitoba and Alberta are considered obese. Quebec and British Columbia have the ____ percentage of obesity in Canada.

A

over 20% of the population in Saskatchewan and NWT are obese, while 15-19% of Ontario, Manitoba and Alberta are considered obese. Quebec and British Columbia have the lowest percentage of obesity in Canada.

56
Q

Direct costs of obesity in Canada estimated to be over $_____, this estimation corresponded to _____% of total health care expenditures for all diseases 
in Canada in 1997. Does this include direct or indirect or both?

A

Direct costs of obesity in Canada estimated to be over $1.8 billion, this estimation corresponded to 2.4% of total health care expenditures for all diseases 
in Canada in 1997.

This estimate does NOT include INDIRECT costs to our society through reduced economic productivity, job loss, sick days from work, etc.

57
Q

What are the diseases associated w/obesity?

A

1) HTN
2) High Blood Glucose/Diabetes
3) Insulin resistance, glucose intolerance
4) CVD
5) Cancers
6) Birth Defects
7) Daytime sleepiness
8) Sleep Apnea
9) Stroke
10) Depression
11) Arthritis – Osteoarthritis and Rheumatoid Arthritis

58
Q

What are the direct vs. indirect costs of obesity?

A

Direct cost: cost of physicians and additional allied health professionals, hospital and nursing home services, the cost of medications, home health care and other medical durables.

Indirect causes: lost productivity that results from illness and death

59
Q

Define obesity?

A

increased body weight caused by excessive accumulation of fat

60
Q

How does nrg expenditure differ in overnourished and undernourished individuals?

A

Obesity is a fine balance btwn the amount of nrg in and nrg expenditure.

  • Over nourished individuals have pos energy balance via less nrg expenditure and greater nrg input.
  • Undernourished or neg nrg balance is greater nrg expenditure (disease conditions etc) or due to malnourishment (under-eating).
61
Q

What are the two body shapes of obesity? Discuss which is generally allocated to which sex and where fat is mostly found

A
  1. Apple shaped
    - Android
    - Male type obesity
    - Central obesity, abdominal obesity
  2. Pear shaped
    - Gynoid
    - Female type obesity
    - Gluteofemoral type
62
Q

What are the 4 different ways to measure obesity?

A
  1. Body Mass Index (kg/m2)
  2. Waist Circumference
  3. Waist to Hip Ratio (WHR)
  4. % body fat (total body fat expressed as a % of total body weight)
63
Q

Describe the BMI and Risk of Comorbidities associated with

1) Healthy Weight
2) Overweight
3) Obese Class I
4) Obese Class II
5) Obese Class III

A

1) Healthy Weight
BMI: 18.5-24.9
Risk of Comorbidities: Normal

2) Overweight
BMI: 25-29.9
Risk of Comorbidities: Increased

3) Obese Class I
BMI: 30-34.9
Risk of Comorbidities: High

4) Obese Class II
BMI: 35-39.9
Risk of Comorbidities: Very high

5) Obese Class III
BMI: ≥40
Risk of Comorbidities: Extremely high

64
Q

When a relative index of weight over height is used, a _____ relationship is observed between relative weight and the presence of comorbidities such as type 2 diabetes and cardiovascular disease.

A

linear or curvilinear

65
Q

Caveats of BMI?

A
  • BMI only relationship between height and weight. Men can have same weight and height, but entirely diff body compositions (one with muscle, which weighs more than adipose tissue, and one with lots of adipose tissue)
66
Q

What waist circumference for men and women is considered obese?

A

Men: >102cm
Women: >88cm

67
Q

What waist to hip ratio for men and women is considered obese?

A

Men >0.9

Women >0.7

68
Q

What % body fat for men and women is considered obese?

A

Men: >18%
Women: >25%

69
Q

Why is waist circumference a better predictor of the change in visceral fat over time than the waist-to-hip ratio (WHR)?

A

E.g. adult woman with a normal BMI of 22 kg/m2, a WC of 72 cm, a hip girth of 95 cm, and a WHR of 0.76. Over time she gained substantial amount of body weight and body fat. Her WC inc substantially but her hip girth also increased considerably, so no change in WHR over the 20-year follow-up. But her abdominal fat accumulation inc substantially, and this change could have been predicted by monitoring the change in WC over time. However, due to the simultaneous increase in hip girth, a health care professional may only focus on the WHR, which would be misleading since the change in WHR could NOT appropriately TRACK the CHANGE in amount of VISCERAL FAT over time.

70
Q

What is the difference between modifiable and non-modifiable risk factors?

A
  • Modifiable risk factors are things we CAN change such as lipid values through medications, waist measurements through diet and exercise, diet etc.
  • Non-modifiable risk factors are risk factors that we CANNOT change such as age, gender and heritable factors.
71
Q

BMI showed a ______ association with risk of MI (myocardial infarction) which was substantially reduced after adjustment for _____ and non-significant after adjustment for ______

A
  • modest and graded
  • waist-to-hip ratio
  • other risk factors
72
Q

What is visceral fat vs. subcutaneous fat?

A
  • Visceral fat (intra-abdominal fat) is all fat located within the peritoneum at the L4-L5 level.
  • Fat outside of the peritoneum is abdominal subcutaneous adipose tissue/fat
73
Q

Why is a clinical index of the presence of metabolic abnormalities of visceral obesity needed in addition to a waist measurement? Example of a marker?

A
  • the shared variance between waist circumference and visceral fat is about 60-70%, indicating there’s considerable variation in visceral adipose tissue accumulation for a given waist circumference.
  • With waist circumference ALONE, we are not able to differentiate if the individual has an excessive amount subcutaneous fat or if it excessive visceral fat. Thus corresponding measures such as triglycerides, LDL, HDL levels are required to adequately assess the individual
  • the simplest metabolic marker being fasting TG concentration
74
Q

How can visceral adiposity be measured?

A

Computed tomography, scanning the abdomen at the level of L4–L5.

75
Q

Describe the leading theory as to how abdominal obesity elicits greater CVD risk

A

THE PORTAL THEORY:

An excessive amt of adipose tissue surrounding the visceral organs allows for a greater absorption of FFA from the adipose tissue. This excessive nrg flux in the form of FFA is cycled directly thru the liver because visceral adipose tissue is drained by the portal venous system, where there is subsequently a greater amount of VLDL lipoproteins released, which results in increased levels of LDL. Also, increased levels of FFA have also been associated with the mechanisms of insulin resistance.

76
Q

Draw a diagram of the hepatic portal system

A

a

77
Q

Draw a diagram of how visceral fat accumulation can lead to CVD

A

Visceral fat accumulation -> Portal FFA -> (Inc lipoprotein synthesis) and (Insulin resistance)

Inc lipoprotein synthesis -> Hyperlipidemia

Insulin resistance -> (Hyperlipidemia) + (Glucose intolerance) + (HTN)

Hyperlipidemia + Glucose intolerance + HTN -> CVD

78
Q

How can obesity act like a virus?

A
  • Obesity can spread from person to person, much like a “virus”.
  • People were most likely to become obese when a friend became obese.
  • Obesity is influenced by your social network.