Modern Medicine Flashcards
How did Alexander Flemming discover penecillin?
1928
- mould (fungi) had grown on one of his petri dishes had killed the bacteria in the dish
- a spore from this mould grown in a room below him had floated into his lab and killed the germs
Why didn’t many people hear of his work?
- he didn’t inject penicillin into animals to prove it
- he published his findings in articles but no one would fund further research
- he initially thought it was just an antiseptic
Who began to research penicillin further?
1930s
-Howard Florey and Ernst Chain at Oxford uni
What factors helped in the mass development of penicillin?
World War II: huge quantities were needed to treat soldiers with infected wounds
Government funding: 1941
Florey met with the US Government who agreed to pay several huge chemical companies to make gallons of it
What short term impact did penicillin?
- by 1945 250,000 soldiers were treated
- around 15% of British and US soldiers would’ve died without penicillin
- after the war it helped to treat illnesses like pneumonia and tonsillitis
What other antibiotics followed?
- streptomycin 1944 (treated TB)
- tetracycline 1953 (skin infection)
- IVF treatment 1978
What has been the long term impact of the discovery of penicillin?
- led to new antibiotics being discovered
- huge Government sponsored programmes
- pharmaceutical industry had more finance to fund research
What negative impact did large pharmaceutical companies have?
- drug companies had sometimes taken short cuts and not tested drugs properly
e. g thalidomide (led to babies being born with deformities)
Why are more antibiotic-resistant bacteria increasing?
Give example of one?
- overuse (doctors prescribe them for minor illnesses
- effectiveness (bacteria evolve)
- patients pick up superbugs in hospitals
MRSA
How did WWI impact surgery?
- mobile x-rays units were used
- first blood banks set up in 1915
- blood transfusion (by 1917 blood was being stockpiled and stored up to 28 days)
- splints increase survival rate of a broken leg from 20% to 80%
How has war hindered medical progress?
- doctors are taken away from normal duties to treat war casualties
- medical research stopped
How did surgery progress after WWII?
- radiation therapy to target cancer
- 1952 first kidney transplant
- 1961 first heart pacemaker
- 1967 Dr Barnard undertook the first heart transplant operation (patient lived for 18 days)
- keyhole surgery (operations through small cuts and using fibre optic cameras)
- laser surgery (1987)
Was the Govt worried about the health of the nation?
- 40% of soldiers who had signed up for the Boer War had been unfit to enlist
- Govt worried that this evidence of poverty would harm the economy and strength of nation
What dod Charles Booth discover?
- published “Life and Labour of the people” in 1889
- it found 35% of London lived in abject poverty
- began to change people’s attitudes towards the poor
What did Seebohm Rowntree find?
- study “Poverty, A study in Town Life” in 1889
- showed that nearly 1/2 the working class people in York lived in poverty
- he coined the term “poverty line”