Modern Medicine (1900-Present) Flashcards
Who was Paul Ehrlich?
Paul Ehrlich was a German doctor who joined Robert Koch’s research team in 1890.
He was fascinated by the way that the body produced antibodies (white blood cells) to fight off infectiom.
Why did Paul Ehrlich call white blood cells ‘magic bullets’?
Ehrlich called them ‘magic bullets’ because they targeted germs but did not kill other cells in the body
In 1889, what did Paul Ehrlich set out to find?
In 1889, Paul Ehrlich set out to find chemicals that could act as synthetic antibodies.
What bacterium was identified in 1905?
In 1905, the bacterium that causes the sexually transmitted disease syphilis was identified.
Ehrlich discovered dyes. What could these dyes do?
Ehrlich discovered dyes that could kill the malaria and sleeping sickness germs.
What did Ehrlich and his team try to search for? What did they hope it would do?
Ehrlich and his team decided to search for an arsenic compound that was a magic bullet for syphilis.
They hoped it would target the bacteria without poisoning the rest of the body.
How many magic bullet compounds did Ehrlich and his team try?
Over 600 compounds were tried, but none seemed to work.
Who joined Ehrlich’s team in 1909, what did he discover?
In 1909, Sahachiro Hata joined the team.
He retested the compounds and saw that compound number 606 actually appeared to work. Ehrlich called the new drug Salvarson 606.
When was Salvarson 606 first used on a human?
Salvarson 606 was first used on a human in 1911
In 1912, what did surgeon James McDonagh publish? What did it say about Salvarson 606?
In 1912, surgeon James McDonagh published a book about it, highlighting the immunity some may develop towards Salvarsan 606 and the effects on the body.
Why were some doctors not keen to use Salvarson 606?
Some doctors were not keen to use the new drug; it was not very soluble and was difficult and painful to inject into veins.
Some doctors believed that people would become promiscuous now that they knew syphilis could be cured.
Despite Ehrlich’s rigorous testing, there were many doctors who didn’t like the idea of giving their patient arsenic, in any form.
What did Gerhard Domagk discover in 1932?
Gerhard Domagk discovered that a red dye called prontosil, killed some blood poisoning germs in mice.
Who did Gerhard Domagk test Prontosil on? What happened?
In 1935, Domagk tested it on his own daughter when she pricked herself on an infected needle. Prontosil cured her.
What was the problem with sulphonamides?
Sulphonamides could still only kill a narrow range of germs.
Serious side-effects of sulphonamide drugs were discovered. What were the side effects?
Sulphonamide drugs can damage the liver and kidneys.
What did Alexander Fleming see many soldiers die from? When?
Alexander Fleming saw many soldiers die of septic wounds eased by staphylococcal bacteria when he was working in an army hospital during the First World War.
Searching for a cure for staphylococcal bacteria, what did Fleming find in 1922? What was the problem with it?
Searching for a cure, he identified the antiseptic substance in tears, lysozyme, in 1922 - but this only worked on some germs.
Describe how Fleming discovered penicillin
1) One day in 1928 he came to clean up some old culture dishes on which he had been growing staphylococci for his experiments.
By chance, a fungal spore had landed and grown on one of the dishes.
2) What caught Fleming’s eye was that the colonies of staphylococci around the mould had stopped growing.
The fungus was identified as Penicillium notatum.
It produced a substance that killed bacteria. This substance was given the name penicillin.
Why could Fleming not take his work on penicillin further?
Nobody was willing to fund further research, so Fleming was unable to take his work on penicillin further
In 1940, what was discovered about penicillin?
Penicillin was effective on mice
In 1939, who continued Fleming’s research on penicillin?
In 1939, Howard Florey, Ernst Chain and their team continued Fleming’s research on penicillin.
Why does penicillin need to be purified?
Penicillin needs to be purified because it is a natural product
What technique did Ernst Chain devise?
Ernst Chain devised the freeze-drying technique, which was an important part of the purification process
How did Florey and Chain make penicillin for their first chemical trial?
They made penicillin for their first clinical trial by growing penicillium notatum in every container they could find in their lab.