MOD 4 - Hematology, Immunity/HIV Flashcards
Transport oxygen and carbon dioxide
Erythrocytes (RBC)
Protect against infection
Leukocytes (WBC)
Participate in clotting blood
Platelets (thrombocytes)
What are the three blood cells?
Erythrocytes (RBC)
Leukocytes (WBC)
Platelets (thrombocytes)
What is the name of the plasma component
Water
Circulates blood cells and noncellular components
Contributes to blood pressure
Relocates to other fluid compartments as needed
Water
Plasma Proteins
Albumin
Fibrinogen
Globulin
Clotting Factors
Affects intravascular osmotic pressure
Albumin
Plasma protein that participates in clotting blood
Fibrinogen
Carries other protein substances
Globulin
Convert a loose blood clot to a stabilized blood clot
Clotting factor
Nutrients of blood components
Glucose
Amini acids
Lipids
Vitamins
Electrolytes
Hormones
Wastes(carbon dioxide, drug metabolites
Provides a source of immediate energy
Glucose
Provide components for cell growth and repair
Amino Acids
A reserve for cellular energy in the absence of glucose
Lipids
Participate in essential physiologic functions
Vitamins
Facilitate a variety of biochemical actions
Electrolytes
Perform multiple endocrine functions.
Hormones
Prevent toxicity when biotransformed and excreted
Waste(carbon dioxide, drug metabolites)
Anemia S/S (inadequate RBC Volume)
Orthostatic hypotension
Thready pulses
Oliguria
Heart Murmur
Normal range RBC count for Men
4.6-6.2 (million/mm3)
Normal range RBC count for Women
4.2-5.4 (million/mm3)
Normal range WBC count for Men
5,000-13,000 (per mm3)
Normal range RBC count for Women
5,000-10,000 (per mm3)
Normal range Platelet count
150,000-450,000 (per mm3)
Increased immature lymphocytes
Normal or decreased granulocytes
Decreased erythrocytes
Decreased platelets
Acute lymphocytic leukemia (ALL)
Same as “ALL,” erythrocytes and platelet counts may be normal or low
Chronic lymphocytic leukemia (CLL)
Decrease in all myeloid-formed cells:
–monocytes
–granulocytes
–erythrocytes
–platelets
Acute myelogenous leukemia (AML)
Same as “AML,” a greater number of normal cells than in the acute form
Chronic myelogenous leukemia (CML)
Classification of Lymphedema
Grade 1 (Mild)
Grade 2 (Moderate)
Grade 3 (Severe)
Grade 1 (Mild)
Circumference of the affected limb is 2 cm, but not more than 4 cm larger than the unaffected limb; the patient is asymptomatic
Grade 2 (Moderate)
Circumference of the affected limb is 4 cm but not more than 8 cm larger than the unaffected limb;
symptoms:
Heaviness in the limb
Pain
Limited movement
Grade 3 (Severe)
Circumference of the affected limb is 8 cm greater than the unaffected limb, involves the entire limb
symptoms:
Infection or cellulitis
Inflammation of connective tissue in or close to the skin
Lymphomas
Hodgkin
Non-Hodgkin
Four types
Hodgkin
Two peaks of onset: ages 15-40 years and older than 55
Hodgkin
Reed-Sternberg cells
Hodgkin
40% of affected clients test positive for Epstein-Barr virus
Hodgkin
B-cell origin
Hodgkin
Usually starts in lymph nodes above the clavicle
Commonly in the neck and chest
15% are below the diaphragm
Spreads downward from the initial site
Hodgkin
More orderly growth from one node to adjacent nodes
More curable
Hodgkin
Thirty subtypes
Non-Hodgkin
Peaks after age 50
Non-Hodgkin
No Reed-Sternberg cells
Non-Hodgkin
More common in industrial countries
Common among clients with immunosuppressants
Non-Hodgkin
B and T cells origin
Non-Hodgkin
Common in the abdomen and tonsils
Can develop in areas other than lymph nodes (e.g., brain, nasal passages)
Non-Hodgkin
Less predictable growth
Spreads to extranodal sites
Less Curable
Non-Hodgkin
Stages of Hodgkin Disease
Stage 1
Stage 2
Stage 3
Stage 4
Single lymph node region
Stage 1
Two or more lymph node regions on one side of the diaphragm
Stage 2
Lymph nodes regions on both sides of the diaphragm, but extension is limited to the spleen
Stage 3
Bilateral lymph nodes affected and extension includes spleen plus one or more of the following;
Bones
Bone Marrow
Lungs
Liver
Skin
Gastrointestinal structures
Stage 4
Types of Lymphocytes in immune response
T - Cells
–Regulator T Cells
—-Helper T cells
–Suppressor T Cells
—-Effector T Cells
—-Cytotoxic T Cells
B - Cells
–Plasma cells
–Memory cells
Recognize antigens
Stimulate B cells to produce antibodies
Helper T Cells
Turn off an immune response
Suppressor T cells
Bind to and destroy invader cells
Stimulate the release of lymphokines
Cytotoxic T Cells
Produce antibodies
Plasma Cells