Mod 13 Heme Flashcards
type of leukemia that causes progressive loss of neutrophil function.
chronic myeloid leukemia
Appears with Reed-Sternberg cells, solid tumor in lymphoid tissue, malignancy of B cells
Hodgkin’s lymphoma
Thrombocytosis
excessive number of platelets, more than 750,000/uL, which can cause excessive clotting can occur with disturbances in blood flow and endothelial damage from
Thrombocytopenia
low number of platelets, fewer than 100,000/uL which can cause bleeding.
Hypercoagulability
INCREASED PLATELET ACTIVITY
* Atherosclerosis
* Diabetes mellitus
* Elevated blood lipid and cholesterol levels
* Increased number of platelets
* Smoking
* Splenectomy
ENHANCED COAGULATION FACTOR FORMATION
* Atrial fibrillation
* Cancer
* Heart failure
* Immobility
* Postsurgical state
* Pregnancy and postpartum period
* Use of oral contraceptives
Decreased platelet production
result from suppression of bone marrow, as occurs in aplastic anemia, or from replacement of bone marrow by cancer cells, as in leukemia. Reduced synthesis of platelets can also occur with HIV infection, exposure to radiation, or use of antineoplastic drugs.
There may be normal production of platelets with excessive pooling of platelets in the spleen
Hemophilia type A
Deficiency of factor VIII, recessive, doesn’t clot properly, Males>, bleeding usually does not occur unless trauma provokes it
Symptoms: compartment syndrome, joint pain, stiffness
Hemophilia type B
Lack of factor IX, doesn’t clot properly, less severe than A, recessive, Males>
Von Willebrand Disease
genetic disorder that causes a deficiency or defect of vWF.
decreased platelet adhesion and reduced levels of active factor VIII, which result in defective clot formation
Disseminated Intravascular Coagulation
both clot formation and bleeding episodes in critically ill patients
resultant clinical condition is characterized by episodes of both coagulation and hemorrhage
Eti: Sepsis
