Mod 1: Intro to Immune System

Question 1

Function of Discrimination

Answer 1

Recognize self from non-self

Question 2

Function of Elimination

Answer 2

• Destroy non-self (pathogen)

- Destroy altered self-cells (ex: cancer)

Question 3

Autoimmunity & Hypersensitivity

Answer 3

Misdirected/overly active immune system

Question 4

Immunodeficiency

Answer 4

Underactive immune system ex: AIDS

Question 5

Antigen

Answer 5

Foreign protein

Question 6

Antibody

Answer 6

A protein produced in response to, and countering, a specific antigen

Question 7

What is the most important property in order for these defense mechanisms to work properly and protect us?

Answer 7

Balance

Question 8

Lymphatic System

Answer 8

Network of vessels that drain fluid (lymph)

Question 9

Circulatory System

Answer 9

Where the lymph comes from and goes after being filtered

Question 10

Immune System

Answer 10

Travels between systems

Question 11

5 Lymphoid Organs and Tissues

Answer 11

-Bone Marrow
-Lymph Nodes
-MALT
-Spleen
Thymus

Question 12

Which are Primary (maturation)?

Answer 12

• Bone Marrow

- Thymus

Question 13

Which are Secondary (activation)?

Answer 13

• Spleen
• MALT
• Lymph Nodes

Question 14

Site of hematopoiesis & B-cell development?

Answer 14

Red Bone Marrow

Question 15

Site of leukocyte development & produced fat and cartilage?

Answer 15

Yellow Bone Marrow

Question 16

Filled with lymphocytes, macrophages, & dendritic cells, filters lymph, first lymphoid structure encountered?

Answer 16

Lymph Nodes

Question 17

Initiates immune responses to

specific antigens encountered along all mucosal surfaces?

Answer 17

MALT

Question 18

Has red pulp filters the blood

& white pulp is the site of development of immune responses against antigens found in the bloodstream?

Answer 18

Spleen

Question 19

Site of T-cell development & maturation?

Answer 19

Thymus

Question 20

How is discrimination achieved?

Answer 20

MHC class I/II

Question 21

4 steps of elimination?

Answer 21

Pathogen, Recognition, Activation, Elimination

Question 22

Evolution of Lymphoid Tissues:

1. all vertebrates have
2. most vertebrates have
3. not many vertebrates generate lymphocytes here
4. not all vertebrates generate

Answer 22

1. GALT
2. Thymus/Spleen
3. Bone Marrow
4. Lymph Nodes

Question 23

Most efficient phagocyte of innate response & is located in tissues

Answer 23

Macrophage

Question 24

Contributor to coagulation wound healing, fibrinolysis & have inflammatory functions that influence adaptive and innate

Answer 24

Platelets (erythrocytes)

Question 25

Phagocyte located in blood, and penetrate tissues

Answer 25

Monocytes

Question 26

Located in granulocytes & play a role in the development of allergies

Answer 26

Mast cell

Question 27

Most abundant type of leukocyte and has characteristics of both granulocytes and phagocytes

Answer 27

Neutrophil

Question 28

Non-phagocytic granulocytes,

role in development of allergies

Answer 28

Basophil

Question 29

Phagocytic granules, defense against multicellular parasites like helminths

Answer 29

Eosinophil

Question 30

In innate & adaptive immunity, first cells of immune system

Answer 30

Dendritic Cell

Question 31

Granular lymphocytes, recognize tumor or virus-infected cells

Answer 31

Natural Killer Cell

Question 32

Non-phagocytic w/ specific receptors at cell surface called TLR

Answer 32

T-cell

Question 33

Produce and secrete highly specialized antibodies

Answer 33

Plasmocytes

Question 34

5 Types of Infectious Agents Examples

1. Cholera
2. Influenza
3. Vaginal Yeast Infection
4. Malaria
5. Schostosomiasis

Answer 34

1. Bacteria
2. Virus
3. Fungi
4. Protozoa
5. Helminths