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TT DD ex 3 and BL ex 2 > Moar Cancer stuffs - Non-Hodgkin lymphoma > Flashcards

Moar Cancer stuffs - Non-Hodgkin lymphoma Flashcards

1
Q

Types of mature lymphoid neoplasms

A
  1. Hodgkin lymphoma
  2. Non-Hodgkin lymphoma
  3. Plasma cell neoplasm
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2
Q

B Cell specific markers

A

CD19
CD22
CD20

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3
Q

T Cell specific markers

A

CD3
CD7
CD5

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4
Q

Germinal center B cell markers:

A

CD20
BCL6
CD10

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5
Q

Neoplastic follicle marker:

A

BCL1
- activate genes for cell cycle progression
BCL2
- suppress apoptosis

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6
Q

Types of Non-Hodgkin Lymphoma

A
  1. Burkitt lymphoma
  2. Follicular lymphoma
  3. Mantle cell lymphoma
  4. CLL/SLL
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7
Q

Types of Plasma cell neoplasm

A
  1. Monoclonal Gammaopathy of Undetermined Significance (MGUS)
  2. Plasmacytoma
  3. Plasma Cell myeloma (Multiple myeloma)
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8
Q

Non-Hogkin lymphoma

A

Malignancy derived from Mature B cells, T cells, NK cells

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9
Q

Translocation/Chromosomal abnormality of Burkitt lymphoma:

A

t(8;14)

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10
Q

Translocation/Chromosomal abnormality of Follicular lymphoma:

A

t(14;18)

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11
Q

Translocation/Chromosomal abnormality of Mantle cell lymphoma:

A

t(11;14)

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12
Q

Translocation/Chromosomal abnormality of CLL/SLL:

A

Del13q14

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13
Q

Cytogenetic marker of Burkitt lymphoma:

A

CD19
CD20

MYC

GC: CD10, BCL6

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14
Q

Cytogenetic marker of Follicular lymphoma

A

CD19
CD20

BCL2

GC:CD10, BCL6

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15
Q

Cytogenetic marker of Mantle cell lymphoma

A

CD19
CD20

BCL1 (cyclin D1),
CD5

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16
Q

Cytogenetic marker of CLL/SLL:

A

CD19
CD20 (weak)

CD23
CD5

17
Q

Which Non-Hogkin lymphoma is associated with EBV?

A

Burkitts lymphoma

  • Sporadic: 30%
  • Endemic: 95%
  • Immunodeficient: 24-40%
18
Q

Non-Hodgkin Lymphoma grade:

  1. Burkitt lymphoma
  2. Follicular lymphoma
  3. Mantle cell lymphoma
  4. CLL/SLL
A
  1. Burkitt lymphoma - High (aggressive)
  2. Follicular lymphoma - Low grade
  3. Mantle cell lymphoma - Low grade (More aggressive than FL and CLL)
  4. CLL/SLL: Low grade
19
Q

Histo findings of Burkitt Lymphoma

A

Starry sky pattern
basophilic cytoplasm
round nuclei

20
Q

Histo findings of FL

A

No tingible body macrophages (homogenous tumor)

Neoplastic follicles in lymph node cortex or medulla (not just cortex)

21
Q

Histo findings of Mantle cell lymphoma

A

larger than normal lymphocyte

22
Q

Histo findings of CLL/SLL:

A

lymphocytosis (in bm/lymph node) > 3 months
Prolymphocyte
Lymph node effacement
proliferation center replace germinal center

23
Q

Which Non-hodgkin lymphoma is usually assymptomatic?

A

Mantle cell lymphoma

CLL/SLL

24
Q

Which Non-hodgkin lymphoma displays a starry sky pattern?

A

Burkitt lymphoma

TT DD ex 3 and BL ex 2 (21 decks)

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