4 DD Common Bacterial pathogens

Question 1

The “big three pathogens”

Answer 1

MRSA
Pseudomonas
Anaerobes

Question 2

three most common organisms responsible for infective bacterial endocarditis:

Answer 2

1. Staphylococcus aureus
2. “Viridans” Streptococci
3. Coagulase negative Staphylococci

Question 3

Catalase Negative bacteria

Answer 3

1. Streptococcus pyogenes
   
   2. Steptococcus pneumoniae
   3. “Viridans” Streptococci
   4. Enterococcus faecalis/Enterococcus faecium

Question 4

Post-streptococcal diseases:

Answer 4

Pharyngitis (disease association)

• can result in:
  1. rheumatic “PHever” and
  2. glomerulonePHritis

Question 5

Disease association for streptococcus pneumoniae

Answer 5

BSMOPS

Bronchitis
Sinusitis
Meningitis
Otitis media
Pneumonia
Septicemia

Question 6

Glomerulonephritis

Answer 6

immune complex disease following skin/pharyngeal infection by Group A Strep (GAS)

• Streptococcal antigen-antibody complexes deposited in kidney → accumulate at the basement membrane → Complement mediated damage to kidney

Question 7

Rheumatic fever (RF):

Answer 7

autoimmune inflammatory disease that may follow Group A Strep (GAS) pharyngitis infection

• Result from production of self-reactive antibodies

Question 8

Typical recovery process of Strep, and what can go wrong

Answer 8

During strep, you produce antibodies → recognize and bind to Streptococcal antigens → recovery

• But sometimes . . . You produce antibodies → recognize bacterial antigens AND host antigens of myocardium and heart valves → progressive antibody mediated tissue damage (RF!)

Question 9

Symptoms of Rheumatic Fever (RF)

Answer 9

F J♥NES

i. Fever
ii. Joints - polyarthritis
iii. ♥ - carditis iv. Nodules (subcutaneous)
v. Erythema marginatum
vi. Sydenham Chorea

Question 10

different pneumococcal vaccines.

Answer 10

1. Adults- (pneumovax, PPSV23) “pneumonia vaccine”

2. Children- Hepta-valent (Prevnar) and newer 13-valent (Prevnar 13) vaccines in kids

Question 11

pneumovax, PPSV23

Answer 11

Adult pneumonia vaccine

○ Provides measurable protection against INVASIVE disease in elderly and immunocompromised adults.
- Ironically, does NOT provide protection against pneumonia.

Question 12

Hepta-valent (Prevnar) and newer 13-valent (Prevnar 13)

Answer 12

Successful Pneumococcal Vaccine in kids