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TT DD ex 3 and BL ex 2 > Moar cancer stuff PCN and CHL > Flashcards

Moar cancer stuff PCN and CHL Flashcards

1
Q

Types of plasma cell neoplasm (PCN)

A
  1. MGUS
  2. Plasmacytoma
  3. Plasma cell myeloma (Multiple myeloma)
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2
Q

Types of CHL

A
  1. Nodular sclerosis
  2. Mixed cellularity
  3. Lymphocyte rich
  4. Lymphocyte depleted
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3
Q

Findings in MGUS

A

Monoclonal Ig in serum or urine
M protein < myeloma levels
no lytic bone lesions

  • NO CRAB symptoms/PCM evidence
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4
Q

MGUS is a precursor to…?

A

plasma cell myeloma (mult. myeloma)

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5
Q

Pt population of:

  1. MGUS
  2. Plasmacytoma
  3. Plasma cell myeloma (Multiple myeloma)
A
  1. MGUS: >50 yr
  2. Plasmacytoma: 5 yr old, Male (2/3)
  3. Plasma cell myeloma (Multiple myeloma): >50 yrs
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6
Q

Types of plasma cytoma

A
  1. plasmacytoma of bone

2. extraosseous plasmacytoma

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7
Q

plasmacytoma of bone findings

A

local tumor of bone w/ multiple myeloma like cells
no other lesions
No M protein (like MGUS and PCM)

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8
Q

extraosseous plasmacytoma findings

A

local mass lesions outside of bone/BM w/ 75% in upper resp. tract

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9
Q

Plasma cell myeloma findings

A

CRAB:
high Ca2+, renal insufficiency, anemia, bone lesion

M protein in serum or urine (mostly IgG)
Elevated creatinine
Rouleux on smear

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10
Q

Most frequent symptom of Plasma cell myeloma (multiple myeloma)

A

bone pain (back/extremities),

weakness/tired

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11
Q

CHL driven by?

A

Hodgkin Reed sternberg cells (RS or HRS),

which are B cell derived

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12
Q

Common markers of CHL

positive for? negative for?

A

CD15, CD30

Neg: CD19, CD20, CD45

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13
Q

Histo of CHL

A

multilobular nucleus
eosinophilic inclusions
large cytoplasms

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14
Q

Breakdown % of CHL

A
  1. Nodular sclerosis
    - 50-80%
  2. Mixed cellularity
    - 20-30%
  3. Lymphocyte rich
    - 5 %
  4. Lymphocyte depleted
    - 1%
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15
Q

Target population of:

  1. Nodular sclerosis
  2. Mixed cellularity
A
  1. Nodular sclerosis:
    - young adults, females
  2. Mixed cellularity:
    - Kids/elderly
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16
Q

EBV predominance in CHL:

  1. Nodular sclerosis
  2. Mixed cellularity
  3. Lymphocyte rich
  4. Lymphocyte depleted
A
  1. Nodular sclerosis
    - EBV in 10-25%
  2. Mixed cellularity
    - EBV in 75%
  3. Lymphocyte rich
    - no EBV
  4. Lymphocyte depleted
    - EBV + usually
17
Q

Whichh CHL is found to have broad collagen bands?

A

Nodular sclerosis

18
Q

Which CHL is found to have nodular growth pattern with residual germinal centers?

A

Lymphocyte rich

TT DD ex 3 and BL ex 2 (21 decks)

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