MOA of Drugs

Question 1

Inhibits cell wall synthesis by binding to PBPs (Penicillin binding proteins)

Answer 1

Beta lactam

Question 2

After binding to lipopolysaccharide (LPS) in the outer membrane of Gram-negative bacteria, it disrupt both the outer and inner membranes. The hydrophobic tail is important in causing membrane damage, suggesting a detergent-like mode of action.

Answer 2

Polymyxin B

Question 3

Inhibits cell wall synthesis by binding to D-ala D a-ala terminus of the nascent peptide

Answer 3

Glycopeptides

Like..

Vancomycin
Teicoplanin
Telavancin
Dalbavancin

Question 4

Inhibits the cell wall synthesis by inhibiting alamin racamase and D-ala D-alanyl ligase

Answer 4

Cycloserine

Question 5

Inhibition of thw binding of the aminoacyl tRNA to the mRNA prevents peptide elongation

Answer 5

Tetracyclines

Question 6

Inhibits protein synthesis by

1. Prevention of ion formation of the initiation complex
2. Cause misreading of mRNA complex
3. Formation of nonfunctional polysomes

Answer 6

Aminoglycosides

Question 7

Blocks the peptide exit tunnel –> dossociation of the peptidyl tRNA from the ribosome

Answer 7

Macrolides

Question 8

Inhibition of peptidyltransferase

Answer 8

Chloramphenicol

Question 9

Inhibits the 23S and 50S subunit

Answer 9

Oxazolidinones- Linezolid

Question 10

Inhibition of RNA polymerase (RNA synthesis)

Answer 10

Rifamycins like

Rifampicin
Rifabutin

Question 11

Inhibition of topoisomerase II (DNA gyrase)

Answer 11

Quinolones/Fluoroquinolones

Question 12

Inhibition of mycolic acid synthesis

Answer 12

Isoniazid

Question 13

Inhibition of RNA polymerase

Answer 13

Rifampicin

Question 14

Inhibits arabinoshl transferase

Answer 14

Ethambutol

Question 15

Inhibition of Dihydroptheroate sythetase

Answer 15

Sulfonamides

Question 16

Inhibition of enzyme dehydrofolate reductase

Answer 16

Pyrimethamine/Trimethoprim