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Pharmacology > ANS > Flashcards

ANS Flashcards

1
Q

Biosynthesis of cathecolamines

Location:

A

Sympathetic post ganglion
Adrenal medulla
CNS

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2
Q

Enzyme required to convert tyrosine to L-DOPA

A

Tyrosine hydroxylase

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3
Q

Enzyme needed to covert L-DOPA to Dopamine

A

L-DOPA decarboxylase

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4
Q

Enzyme needed to convert dopamine to NE

A

Dopamine-B-hydroxylase

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5
Q

Enzyme needed to convert NE to epinephrine

A

Phenylethanolamine-N-methytransferase

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6
Q

Responsible for the metabolism of catecholamines

A

MAOs and COMTs

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7
Q

Responsible for the metabolism of Acetylcholine

A

Acetylcholinestrases

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8
Q

Inhibits Formation of L-DOPA

A

Methyrosine

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9
Q

Dopamine storage inhibitor

A

Reserpine

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10
Q

Releasers of catecholamines

A 
Tyramine
Amphetamine
Ephedrine
ANGF
a-latro toxin
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11
Q

Inhibits Release of catecholamines

A

Guanethedine
Guanedrel
Bretylium

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12
Q

Reuptake inhibitors of catecholamines

A

TCAs
Cocaine
Robexetine

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13
Q

B1 > A1

Choices:
A. Epi
B. NE
C. Dopamine

A

B. NE

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14
Q

B1 = B2&raquo_space; A1

Choices:
A. Epi
B. NE
C. Dopamine

A

A. Epi

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15
Q

D1 > B1 > A1

Choices:
A. Epi
B. NE
C. Dopamine

A

C. Dopa

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16
Q

Metabolism of Epi and NE’s product

A

Vanillylmandelic acid or 3-methoxy-4-OH-madelic acid

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17
Q

Metabolism of Dopamine’s product

A

Homovanillic acid

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18
Q

1st line tx for anaphylactic shock

A

Epinephrine

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19
Q

1st line tx for septic shock

A

NE

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20
Q

aka adrenaline

A

Epinephrine

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21
Q

Aka levarterenol

A

Norepinephrine/ Noradrenaline

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22
Q

Mgt of septic and cardiogenic shock
Mgt of AHF
Diuresis

A

Dopamine

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23
Q

Adverse effect during a1 overstimulation

A

Digital necrosis

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24
Q

Adverse effect during B1 overstimulation

A

Ventricular tachyarrhythmia

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25
Q

aka isoprenaline

A

Isoproterenol

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26
Q

1st line tx for cardiogenic shock

A

Dobutamine

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27
Q

2 examples of SABA or short acting B agonist

A

Albuterol and Terbutaline

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28
Q

aka albuterol

A

Salbutamol

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29
Q

2 examples of Tocolytic B1 agonists

A

Ritodrine and isoxsuprine

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30
Q

Mgt of symptomatic bradycardia

A

Terbutaline

31
Q

Selective a1 agonists

P
P
M
T
O
N
A 
Phenylephrine
Propyhexedrine
Methoxamine
Tetrahydrozoline
Oxymetazoline
Naphazoline
32
Q

Selective a2 agonists

C
M
G
G

A

Clonidine
Methyldopa
Guanabenz
Guanfacine

33
Q

Only 4 safe antihypertensive drugs for pregant

A

Mommy Nife hates labor (MNHL)

Methyldopa
Nifedipine
Hydralazine
Labetalol

34
Q

Active metabolite of Methyldopa

A

a-methyl norepinephrine

35
Q

Selective D1 agonist used in the mgt of HTN crisis

A

Fenoldopam

36
Q

Centrally acting sympa drugs

P
P
P
A
M
A 
Phentermine
Phenmeyrazine
PPA- phenylpropanolamine
Amphetamine
Methylphenidate
37
Q

1st line tx in mgt of ADHD

A

Methylphenidate

38
Q

Centrally acting sympa drugs used in the mgt of anorexia

PPP

A

Phentermine
Phenmetrazine
PPA- Phenylpropanolamine

39
Q

Centrally acting sympa drugs used in the mgt of narcolepsy

AP

A

Amphetamine and phentermine

40
Q

Non selective a antagonist

A

Phenoxybenzamine

Phentolamine

41
Q

a2 atagonists

RY

A

Rauwolscine

Yohimbine

42
Q

Non selective Beta blockers

“NSTP”

A

Nadolol
Sotalol
Timolol
Propanolol

43
Q

B1 blockers aka cardioselective beta blockers

CBBEAAM “c-beam”

A 
Celiprolol
Bisoprolol
Betaxolol
Esmolol
Acebutolol
Atenolol
Metoprolol
44
Q

Beta blockers w/ ISA (intrinsic sympathomimetic activity)

Celi-CAPP-Lab

A 
Celiprolol
Carteolol
Acebutalol
Pindolol
Penbutol
Labetalol
45
Q

Beta blockers with membrane stabilizing effect aka local anesthetic effect

Prop(esor) Met Pin (nag) Ace sa Lab

A 
Propanolol
Metoprolol
Pindolol
Acebutalol
Labetalol
46
Q

B blockers with a1 blocking effect

i Lab Carbs

A

Labetalol

Carvedilol

47
Q

Most Cardioselective b blocker

A

Nebivolol

48
Q

Biosynthesis of Ach

Location

A

All pre-ganglionic
Cholinergic, post ganglion
CNS
Somatic nerve

49
Q

Enzyme needed to produce Ach from choline and acetyl coa

A

Choline acetyltransferase

50
Q

Inhibitor of Active uptake of choline

A

Hemicholinium

51
Q

Inhibits storage of Ach

A

Vesamicol

52
Q

Releaser of Ach

A

a-latro toxin

53
Q

Release inhibitor of ach

A

Botulinum toxin

54
Q

Location of Nm receptor

A

Neuromuscular end plates

55
Q

Location of Nn

A

Ganglion

56
Q

M selective choline ester (direct acting parasympa drug)

A

Betanechol

57
Q

Non selective choline ester (direct acting parasympa drug)

A
M
C

A

Ach
Metacholine
Carbachol

58
Q

Non selective alkaloid (direct acting parasympa drug)

A

Arecoline

59
Q

N selective alkaloid (direct acting parasympa drug)

A

Nicotine
Varenicline
Lobeline

60
Q

M selective alkaloid (direct acting parasympa drug)

A

Muscarine and Pilocarpine

61
Q

Aka eserine

A

Physostigmine

62
Q

Aka ambenonium

A

Pyridostigmine

63
Q

Used in dx of myasthenia gravis

A

Edrophonium

64
Q

Used in tx of myasthenia gravis

A

Pyridostigmine

65
Q

Tx for atropine poisoning

A

Pilocarpine

66
Q

Tx for sjorogen’s syndrome

A

Pilocarpine

67
Q

Tx for organophosphate poisoning

A

Pralidoxime or Diacetylmonoxime (DAM)

-aka Enzyme regenerators

68
Q

Tx for AE of parasympa drugs

A

Atropine or enzyme regenerators like DAM and pralidoxime

69
Q

M1 blockers

A

Pirenzipine

Telenzepine

70
Q

M3 blockers

G
H
C
D

A

Glycopyrrolate
Hyoscine N butyl Bromide
Clidinium
Dicycloverine/Dicyclomine

71
Q

Ganglionic/ Nn blockers

A

Hexamethonium
Mecamylamine
Trimethaphan

72
Q

Depolarizing Non competetive Neuromuscular/ Nm blocker

A

Succinylcholine

73
Q

Non Depolarizing - competetive Neuromuscular/ Nm blocker (ISOQUINOLONES)

A

Atracurium
Mivacurium
Cisatracurium
Tubocurarine

74
Q

Non Depolarizing - competetive Neuromuscular/ Nm blocker (STEROIDS)

A

Rocuronium
Pancuronium
Vecuronium

Pharmacology (6 decks)

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