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Pharmacology > Autacoids > Flashcards

Autacoids Flashcards

1
Q

Enzyme required in the formation of histamine

A

L-histidine decarboxylate

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2
Q

Precursor of histamine

A

L-histidine

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3
Q

Local hormones wherein the site of secretion is near the site of action

A

Autacoids

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4
Q

For examples of autacoids

H
S
E
B

A

Histamine
Serotonin
Eicosanoids
Bradykinin

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5
Q

Function of this H receptor is vasodilation,brochodilation, pain & itch, local edema

A

H1

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6
Q

Function of this H receptor is gastric Acid secretion

A

H2

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7
Q

Function of this H receptor is inhibition of H release

A

H3

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8
Q

Used in pulmonary stress test and determination of gastric acid secretion

A

Histamine

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9
Q

H1 agonist
H3 antagonist
Used in mgt of vertigo

A

Betahistine

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10
Q

Components of cold medications

A

Aklylamines like brompheniramine and chlorpheniramine

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11
Q

Most potent H2 blocker

A

Famotidine

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12
Q

Least potent H2 blocker

A

Cimetidine

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13
Q

1st line tx for acid peptic diseases

A. PPIs
B. H2 blockers

Choose 1

A

PPIs

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14
Q

1st line tx in the mgt of acute GI ulcer bleeding

A. PPIs
B. H2 blockers

Choose 1

A

H2 blockers

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15
Q

AE of cimetidine

A

Antiandrogenic effects

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16
Q

Precursor of serotonin

A

Tryptophan

17
Q

5 HT means

A

5-hydroxytryptamine / serotonin

18
Q

5-HT1a function

A

Inhibition of further release of H

19
Q

5-HT1B and 5-HT1D function

A

Vasoconstriction

20
Q

5-HT2a function

A

Oxytocic effect

21
Q

5-HT3 function

A

Chemoreceptor trigger zone
Vomiting center
Emesis

22
Q

5-HT1A partial agonist (anxiolytic)

A

Buspirone

23
Q

5-HT 1B/ 1D agonist

A

“Triptans” like sumatriptan, zolmitriptan, etc.

24
Q

5-HT2a agonist

A

Ergotamine
Ergonovine
Ergometrine

25
Q

5-HT2a antagonist

A

Methy sergide

26
Q

Mgt of post partum bleeding

A

Ergonovine

27
Q

5-HT3 antagonists

A

“Setrons”

Ondasetron, etc.

28
Q

Tx in the mgt of chemotherapy-induced N&V

A

5-HT3 antagonists

29
Q

Mgt of constipation

A

5-HT4 agonists like

Tegaserod
Prucalopride

30
Q

5,8,11,14-eicosatetraenoic acid

A

Arachidonic acid

31
Q

Arachidonic acid has ______ unsaturations

A

4

32
Q

Major source of arachidonic acid

A

Phospholipids

33
Q

Minor source of arachidonic acid

A

Phosphatidyl inisitol

34
Q

Enzyme needed to convert phospholipids into arachidonic acid

A

Phospholipase 2 (PLA2)

35
Q

Enzyme needed to convert phosphatidyl inositol into arachidonic acid

A

Phospholipase C

36
Q

Enzyme needed to convert arachidonic acid into leukotrienes

A

5-LOX aka 5 Lipoxygenase

37
Q

Enzyme needed to convert arachidonic acid into prostaglandin

A

COX aka Cyclooxygenase

Pharmacology (6 decks)

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