MNGP

Question 1

Germline and myeloid

Answer 1

Myeloid neoplasm classification

I. Myeloid neoplasms with germ line predisposition without a preexisting disorder or organ dysfunction
* AML with germ line CEBPA mutation
* Myeloid neoplasms with germ line DDX41 mutation*

II. Myeloid neoplasms with germ line predisposition and preexisting platelet disorders
* Myeloid neoplasms with germ line RUNX1 mutation*
* Myeloid neoplasms with germ line ANKRD26 mutation*
* Myeloid neoplasms with germ line ETV6 mutation*

III. Myeloid neoplasms with germ line predisposition and other organ dysfunction
* Myeloid neoplasms with germ line GATA2 mutation
* Myeloid neoplasms associated with BM failure syndromes
* Myeloid neoplasms associated with telomere biology disorders
* JMML associated with neurofibromatosis, Noonan syndrome or Noonan syndrome-like disorders
* Myeloid neoplasms associated with Down syndrome*