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FCPath(SA)Haem - HaemOnc > DDx > Flashcards

DDx Flashcards

1
Q

DDx for AML with Dysplasia

A
  1. AML t(6;9)
  2. MECOM
  3. AML-MR
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2
Q

DDx for AML with Monocytoid appearance (M4/M5)

A
  1. NPM1
  2. KMT2A (adults)
  3. APL (microgranular)
  4. NUP98
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3
Q

DDx for AML with M7 fts

A
  1. t(1;22)
  2. NUP98
  3. MECOM
  4. KMT2A (kids)
  5. CBFa1::GLIS (RAM IMPT)
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4
Q

DDx for Basophilia

A
  1. Acute basophilic leukaemia
  2. t(6;9)
  3. AML t(9;22)
  4. CML-BP
  5. Mast cell leukaemia
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5
Q

Differential diagnosis of Eosinophilia (9)

A
  1. Reactive (Drugs, Allergy/Infection, Solid tumour/LPD)
  2. M/L with TK mutation
  3. CML
  4. AML inv16
  5. Mastocytosis
  6. MPN/Overlap
  7. B-ALL t(5;14)
  8. L-HES / M-HES
  9. CEL
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6
Q

DDx for B-ALL with Myeloid Markers

A
  1. BCR::ABL1 (CD13,CD33 and CD25)
  2. KMT2A (CD15 and CD65)
  3. IgH::IL3/t(5;14) (CD13, CD33 and CD123)
  4. ETV6::RUNX1/t(12;21) (CD13, CD33)
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7
Q

What is the differential diagnosis of SMZL?

A
  • CLL
  • Hairy cell leukemia
  • Mantle Cell Lymphoma
  • Follicular lymphoma
  • Lymphoplasmacytic lymphoma
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8
Q

DDx for B-cell neoplasms that do not express pan B-markers

2

A
  1. CLL
  2. PBL
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9
Q

DDx for CD19/CD10 Positive B-cell neoplasms (CD5-)

6

A
  1. B-ALL
  2. Haematogones
  3. FL
  4. BL
  5. DLBCL
  6. MM
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10
Q

DDx for CD19/CD5 Positive B-cell neoplasms (CD10-)

4

A
  1. CLL
  2. MCL
  3. B-PLL (SBLwPN)
  4. 5% of DLBCL
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11
Q

DDx for CD19 Positive B-cell neoplasms (CD5 and CD10-)

2

A
  1. HCLv
  2. MZL (SMZL, NMZL, MALT)
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12
Q

Cyclin D1 positivity

A

MCL

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13
Q

Annexin 1 Positivity

A

HCL

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14
Q

DDx for villous lymphocytes

5

A
  1. HCL
  2. SMZL
  3. HCLv
  4. BPLL
  5. SDRPL
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15
Q

DDx for HRS cells

6

A
  1. HL
  2. NLP HL and TCHR LBCL
  3. EBV+ DLBCL
  4. Peripheral T, NOS
  5. Anaplastic large cells Lymphoma
  6. 1’ DLBCL of CNS
  7. 1’ mediastinal LBCL
  8. 1’ Effusion lymphoma

Non neoplastic: Megs/Carcinoma

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16
Q

DDx for CD30+ lymphomas

HL, BCL(5), TCL(5)

A

I. cHL

II. BCL
* Anaplastic variant of DLBCL
* ALK+ LBCL
* PBL
* 1’ effusion lymphoma
* Lymphomatoid granulomatosis

III. TCL
* ATCL
* PTCL, NOS
* ALCL
* Extranodal NK/TCL
* Enteropathy ass. TCL

17
Q

CHL subtypes tend to have a male predominance, with the exception of which subtype?

A
  • Nodular sclerosing HL
    • slight female predominance
18
Q

What is the expression of OCT2 and BOB1

in CHL HS cells?

A
  • absence of the transcription factor (OCT2) and its cofactor (BOB1)

Note: EMA is also negative in most cases

19
Q

How can CHL lymphoma be mistaken for ALCL

and what IHC helps differentiate the two well?

A
  • if the CHL is rich in neopastic cells it can morphologically resemble ALCL
  • IHC
    • CHL = PAX5 (+)
      • EMA and ALK protein (-)
    • Detection of EBV (LMP1) favors CHL over ALCL as well
20
Q

What is one of the most difficult d/d

with CHL to differentiate?

A
  • DLBCL with anaplastic morphology and CD30 (+) cells
    • especially if it is within the mediastinum
21
Q

DDx for Intrainusoidal Growth Pattern

A
  1. TLGL
  2. NKLGL
  3. Hepatosplenic TCL
  4. SMZL
  5. SDRP Lymphoma
  6. SBCLwPN
22
Q

Presence of MYD88 mutations point to which entity instead of SMZL?

A

Lymphoplasmacytic lymphoma

Note: although rarely SMZL can have this mutation.

23
Q

Different causitive factors in MALT lymphoma?

A
  • Gastric - H.Pylori
    • t(18;14)
    • Treatment = Eradication of H. Pylori (PPI, Clarithromycin, Amoxil/Metronidazole)
    • If they do not respond = RadioTx/Chemo
  • Ocular - Chlamydia
  • Skin - B. Burgdorferi
  • Salivatory glands - Sjogren
  • Thyroid - Hashimotos
24
Q

DDx for Lytic Bone Lesions

Go Shimla

A
  1. Gauchers
  2. Osteosarcoma
  3. Systemic mastocytosis
  4. HL/HLH
  5. Infections
  6. Mets/MM
  7. Langerhans Histiocytosis
  8. Adult TCL
25
Q

DDx for MProtein

A
  1. PCNs
  2. CLL
  3. SMZL
  4. LPL
  5. MALT
26
Q

DDx for GC B-cell Neoplasms

A
  1. DLBCL
  2. BL
  3. FL
27
Q

What are the clinical spectrum of neoplastic diseases associated with HTLV-1 infection?

A
  • ATLL
  • LGL
28
Q

What are the non-neoplastic diseases associated with HTLV-1 infection ?

A
  • HTLV-1 associated myelopathy (tropical spastic paraparesis)
  • HTLV-1 associated infective dermatitis
  • Other HTLV-1 Inflammatory Disorders
    • Uveitis
    • Thyroiditis
    • Pnemonitis
    • Myositis
29
Q

DDx of EBV+ Neoplastic conditions

A
  1. HL
  2. BL
  3. DLBCL
  4. PBL
  5. Extranodal T/NK
  6. Angioimmunoblastic T
30
Q

DDx for HepC virus associated neoplasms

A
  1. SMZL
  2. LPL/WM
  3. Cryoglobulinaemia
31
Q

DDx for HHV8 virus associated neoplasms

A
  1. 1’ effusion lymphoma
  2. Multicentric castlemans
32
Q

DDx for massive splenomegaly

A
  1. CML and MPNs
  2. Malaria
  3. Gauchers
  4. Lymphomas
    • Splenic B-cell lymphomas (SDRPSBcL, SBCLwPN)
    • Hepatosplenic TCL
  5. Infective: TB, Schistosomiasis, Hepatitis
  6. Inflammatory: Sarcoidosis, RA, SLE
  7. Infiltration: Gauchers, Nieman Pick, Rosai Dorfman, Amyloid
  8. Sequestration: SC
33
Q
A
34
Q

If you think MDS-IB rule out…

A
  1. AML
  2. biTP53

FCPath(SA)Haem - HaemOnc (20 decks)

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