CH Flashcards
CH, ARCH, CHIP, ICUS, CCUS
1
Q
Definition of CH
A
Clonal Haematopoiesis
* Clonal proliferation of HSC & progenitors
* Any cause
2
Q
Definition of ARCH
A
Age-related CH
* Aging and CH
* No cytopenias/haem malignancy
3
Q
Definition of CHIP
A
Clonal hematopoiesis of indeterminate potential
* CH and somatic mut (VAF>2%)
* No cytopenias/haem malignancy
4
Q
Definition of CCUS
A
Clonal cytopenia of undetermined significance
* CH and somatic mut (VAF>2%)
* Cytopenia (persistent and unexplained)
* No haem malignancy
5
Q
Definition of ICUS
A
Idiopathic cytopenias of undetermined significance
* Cytopenia (persistent and unexplained)
* No mutation/haem malignancy