Mnemonics Flashcards
my fabrite activity is ceramics. We made A small galaXy.
The spinning wheel made my fingers tingle and skin caked in red clay. I did it until the ceramic became dry. After it was finished, I loved it and peed a lil.
FABRY
Enzyme: alpha-galactosidase A
Build up: Ceramide Trihexoside
X-linked recessive inheritence
Early: peripheral neuropathy, angiokeratoma, hypohidrosis
Late: cardiovascular disease, renal failure
oh my Gosh, he is such a big Gucci bro (in crying voice). There is nothing in his bones.
Gaucher’s disease (the most common)
Enzyme: Glucocerebrosidase
BUildup: Glucocerebroside.
Tissue paper cytoplasm*
Symptoms: Bone necrosis* adult hepatoslenomegaly, pancytopenia or thrombocytopenia
A gang of 6 small Jews lost their job at general Motors for eating an onion sunday with cherry on top which made them dumb, blind, deaf and paralyzed.
Tay Sach’s Disease
Enzyme: hexosaminidase A
Buildup: GM2 Ganglioside
SMALL* no hepatosplenomegaly-differentiates it from Nieman Pick.
*Cherry red macula!
Autosomal recessive, presents at birth: motor weakness, seizures, vision and hearing loss, intellectual disability and paralysis. Death within 4 yrs of age
Dilated neurons with lipid filled vacuoles in CNS. Lysosomes with onion skin.
Pick your big nose with your sphinger. Took out a foamy booger with a lil blood on top and a little bit of brain too!
Niemann-Pick
Enzyme: Sphingomyelinase
Buildup: Sphingomyelin
also has cherry red macula (a, also in Ashikanze Jews
but BIG: hepatosplenomegaly.
Microcephaly, severe mental retardation, zebra bodies in inclusions
Foamy macrophages
Early death
Bro this glob of Krabbe meat is out of this world.
I’m ]ogleing it and its making me tingle with excitement
Krabbe Disease
Enzyme: beta Galactocerebrosidase
Buildup: galactocerebroside
Globoid Cell - glob of crab
Optic atrophy, death of oligodendrocytes, peripheral neuropathy.
X-marks the spot. I don’t care about you.
Hunter’s Disease
Enzyme : Iduronate sulfatase (L iduronate in Hurler)
Buildup: dermatan sulfate (scope is touching your skin)
- *X LINKED recessive ! (other is Fabrite)
- unlike Hurler, has no corneal clouding! (hunter needs to see.) Aggressive behavior.
1,2 buckle my shoe
3,4 kick down the door
5,6 pick up sticks
7-8 Keep it straight
Reflexes
S1,S2 - achilles
L3,L4 - patellar
C5-C6 - biceps,brachioradialis
C7,C8 -triceps
Down on all 4’s
Teat pore
Belly Butten
Dermatomes
L4=knees
T4-nipples
T10- belly button.
some say marry money but my brother says big brains matter most
Cranial nerves
- sensory
- sensory
- motor
- motor
- both
- motor
- both
- sensory
- both
- both
- motor
- motor
Must stay A-wake 2 dine .
Also cold air helps to stay awake so CET the AC to stay awake
2nd generation: nonsedating, do not cross the BBB
- DesloratADINE
- FexofenADINE (Allegra)
- LoraTADINE (Claritin)
- CETirizine (zyrtec)
- ACIVASTINE
1st gen: lipophilic- motion sickness, sleep aid
- diphenhydramine (Benadryl)
- clorpheniramine
- hydroxyzine
- promethazine
- dimehydrinate - (Dramamine)
Saying “Broca” vs saying “wernicke”
These two are opposites. So it comes down to which one is fluent (output intact) vs nonfluent (output fucked)
So Wernicke is much harder to say than Broca so Wernicke is fluent aphasia, Broca is non-fluent
argylL - robertsoN pupil
light-near dissociation
Pupils are small bilaterally and irregular
- pupils will not react to light!
- pupils WILL react to accommodation
associated with syphillus and diabetes
Uncle blows hemp and coke
Transtentorial Uncal herniation - clinical triad of
- blown pupil - CN3
- HEMiplegia - cerebral peduncles
- Coma - reticular formation - decreased consciousness
Don’t Eat Greasy Foods
Lateral to medial of deep cerebellar nuclei
Dentate, Emboliform, Globose, Fastigial
D1R
Dopamine 1 Receptor
D1R = DIRect pathway of Basal Ganglia
Dopamine always facilitates movement. Dopamine increase gabaergic output of the striatum onto the Gpi, disinhibition of the VL/VA thalamus
When you PARK your car it is at REST
Parkinsons has resting tremor in the distal appendages. Tremor is alleviated by intentional movement.
Parkinson TRAPS your body
Tremor (pill rolling at rest) Rigidity (cogwheel) Akinesia (or bradykinesia) Postural instability Shuffling gait
alCAPONE in COMTON
Catechol O methyl transferase inhibitors
Tolcapone - more potent, used in addition to levodopa/carbidopa (Sinemet) to increase plasma half life of levodopa.
Used for patients with late PD who have developed rest fluctuations.
- Tolcapone - potent, hepatotoxic**
- Entacapone - the more recommedned
Stalevo: levodopa, carbidopa, entacapone
dEcErEbratE
vs
decorticate
Decerebrate - lesion below the midbrain, all limbs extend.
Decorticate - lesion above the midbrain, lower limbs extends, upper limb flexes
Decorticate is closer to the cortex
Decerebrate is close to the cerebellum
Executive
Gate
Where you are in space
Executive - cerebellum, this monitors ongoing movement. It receives the plans from the motor cortex via the pontine nuclei. Then it monitors the ongoing movement, compares it to the plan, goes through SCP to correct for movement. If mistakes were made you learn, go through ION back to the lateral cerebellum.
Gate - basal ganglia - it is tonically on, inhibiting voluntary movement so if you lose it, all movements are coming out.
Vestibular nuclei can tell where your head is in space.
Ethosuximide EFGHIJ
Side effects of Ethosuximide
Fatigue GI distress Headache Itching and urticaria) stevens-Johnson syndrome
Sux to have Silent Seizures
Ethosuximide is first line for absence seizures
Hypothalamus
TAN HATS
- Thirst and water balance,
- Adenohypophysis (anterior pituitary - secretes hormones)
- Neurohypophysis (neuroendocrine cells project axons to posterior pituitary)
- Hunger
- Autonomic System
- Temperature
- Sexual urges
Hypothalamus:
If you zap your lateral area you shrink laterally
Lateral area of hypothalamus associated with hunger, destruction > anorexia, failure to thrive, stimulated by ghrelin, inhibited by leptin.
Hypothalamus A/C
lateral preoptic nucleus is the heat loss center. Anterior = cooling, parasympathetics
You need sleep to be *charismatic
Suprachiasmatic nucleus is responsible for the circadian rhythm and sleep.
If you zap your ventromedial area of hypothalamus, you grow ventrally and medially
Ventromedial area is responsible for satiety, destruction of it, (craniopharyngioma for example) leads to hyperphagia. Stimulated by leptin.
If you zap your posterior hypothalamus you become a poikilotherm
cold blooded like a snake. Lesion to the anterior part can result in hyperthermia, lesion in the caudal part can result in hypothermia when environmental temp is low or Poikilothemia (because the anterior part fiber coursing through the posterior parts get lesioned also.
Subcortical structures
want to go into THUB?
Thalamus
Hypothalamus
Upper brainstem
Basal forebrain.
NTs of diffuse projections
HANDS
the monoamines
Histamine - (Tuberomamillary) cell bodies in hypothalamus
Acetylcholine - Basal forebrain - Nucleus basalis of Meynert
Norepinephrine - Locus Coeruleus
Dopamine - VTA (especially projects to frontal lobe)
Serotonin - Raphe n.
-loss of these leads to confusion and drowsiness, not coma, ex. acetylcholine or histamine.
Alzheimer patients gallantly swim down the river
Galantamine
Donepezil
Rivastigmine
Are all anticholinesterases
Migraine: POUND
Pulsatile
One day duration, Unilateral,
Nausea
Disabling
Hairy Gummy Broken Baby
Phenytoin
Hirsuitsm
Gum hyperplasia
Osteomalcia - vit D deficiency
Baby - pregnancy teratogen category D
No Thing Beats Trying Anal
Prophylactic
NSAIDS
Triptans
B-adrenergic
Tricyclic
Anticonvulsants
PAM is 1 Horny Teen
Ptosis
Anhydrosis
Miosis
any lesion above T1.
Names of beta blockers
A-M (heart specific) B1
N-Z (nonselective) (includes B2)
Snout and Spin
EBM
High Sensitivity means you are getting everyone who actually has a disease (true positive)/(true positive + FALSE NEGATIVE). There is very few false negatives. This means if you get a negative test you can be certain they don’t have it “ruling OUT”
High specificity means you are getting everyone who doesn’t have the disease (true negatives)/(true negative + FALSE POSITIVE). So false positive are really low, if you get a positive you can be pretty certain they have it. “ruling IN”
Somepeople BS nomeningitis HAve GENeric SAd and BAd lies
Common causes of acute bacterial meningitis
S. pneumo
Group B strep agalactae
Neisseria meningitis
Haemophilus influenzae type B
Gram negative enteroviruses
Staph Aureus (uncommon)
Bacillus anthracis
THE Mighty King Proposes to Oprah
Thiopental Midazolam Ketamine Propofol Opiods
Intravenous anesthetics