mm pp 3 Flashcards
Innate Response to Bacteria
Inflammation, Complement, Phagocytosis with neutrophils + Dendritic Cells + Macrophages
Adaptive Immune Response to Bacteria
B and T Cell activation, Ab Production (IgM, IgG, IgA)
Bacterial Compounds that Provoke the Immune Response
LPS (Endotoxin), Lipotechoic Acid, Glycolipids and Glycopeptides, Polyanions, Peptidoglycan Fragments
LPS
Endotoxin. Secretes IL-1, IL-6, TNF-Alpha, and chemokins.Cause Fever which increase DCs, Macrophages, and B-Cells.
Help Evade Immune Response
Capsules can prevent Phagocytosis, Virulence Factors can help evade IR, Toxins/Superantigens-Cytokine storm
IR to Virus
IFN Alpha and Beta; NK Cells-Cytotoxic for infected Cells; CD1:TH4 Cells-Inflammation, activate CD8, NK, and Macrophages; CD8’s- Cytotoxic; Antibodies- Neutralizing; Macrophages-Phagocytosis and APC
Many symptoms of viral infections are due to _________ to the virus
Effects of Immune Response
Immune Response to Fungi
PMNs, Macrophages, Antimicrobial Peptides, Ab and CD4s, TH1 and TH17
Immune Response to Parasites
IgE, Eosinophils, Mast Cells, Macrophages, PMN’s and CD4’s
How viruses evade IR
Change or hide Ags, Ag Variation, Virokine-Interfere with IFN and other cytokines, reduce expression of MHC 1
How Fungi evade IR
Very similar to host and as such are hard to recognize.
How parasites evade IR
Alter Ag’s, intracellular, Cysts, inhibit Phagocytosis
Hypersensitivities
Immediate (IgE) and Delayed(Cell Mediated)
Immunodeficiencies
Genetic and Aquired
Herd Immunity
Large Group Resistant=All resistant so it cant spread