mm pp 1 Flashcards
Medical Microbiology
The study of microorganisms that cause human disease
Antoni Van LeeuwenHoek (1632-1723)
Made the first simple microscope to view “animalcules” (microorganisms)
Koch and Pasteur
Credited with developing the Germ theory
Carolus Linnaeus
Developed system for naming and classifying plants, animals, and similar organisms together (Taxonomic systems)
Otto Muller
Grouped Leeuwenhoeks organisms into five categories: fungi, protozoa, alge, prokaryotes, small animals
Friedrich Henle(1840)
First proposed the germ theory
Louis Pasteur
Father of Microbiology
Robert Koch
Father of Microbiology Lab
John Snow (1854)
Studied Cholera
Koch’s Postulates
- Agent must be isolated and grown outside the host, 2. Suspected causative agent must be found in every case of the disease and be absent from healthy host, 3. When agent is introduced in healthy host, the host must get the disease, 4. Same agent must be re-isolated from diseased experimental host
Helicobacter Pylori
Gram Negative Bacteria that is thought to play a part in Ulcers and stomach lesions
Chemotherapy
Using chemicals to treat microbial infections
Paul Ehrlich (1910)
treated syphilis with arsenic compound
Alexander Fleming (1928)
Left out plates that caused penicillium chrysogenum to kill staph on a bacterial plate-helped with development of antibiotic (also discovered lysozyme)
Chain and Heatly in Florey’ lab (1940’s)
Developed a stable form for therapy with penecillin. Allies used it, Germans did not.
Gerhard Domagk (1935)
Sulfanilamide
Selman Waksman (1943)
Streptomycin
All currently used antivirals are _______
Synthetic
Anti-Microbial
General use-Kills microbes
Anti-Fungal
Kill Fungus
Anti-Parasitic
Kill Parasites
Microorganisms in Medical Microbiology
viruses, prokaryotes, fungi, parasites, prions
Prion examples
CJD, Bovine Spongioform Encephalopothy
Smallest Complex Pathogen with DNA or RNA genome (Also has a protein capsid and some have envelopes)
Virus
Size range of viruses
18-600 nm
How many different types of viruses are there?
3000+ viruses
How many different viruses infect humans and animals?
650+ viruses infect humans and animals
Viral Envelope is made of?
Lipids
Ivanovsky
TMV research
Reed
Yellow Fever Research
Rous
Rous Sarcoma Virus Research
Rabies Virus Shape
Bullet shape
Bacteria
Unicellular- Potentially Pathogenic prokaryotic organisms that reproduce asexually
Size of Bacteria
1-20 micrometer or larger
Two primary types of Bacteria
Gram positive and Gram Negative