MKSAP Heme/Onc

Question 1

Patients with mild forms of hereditary spherocytosis can be monitored and should receive ________

Answer 1

supplemental folate

severe dz (transfusion dependent, symptomatic, massive splenomegaly) = splenectomy

Question 2

hereditary spherocytosis is caused by

Answer 2

deficiencies of the erythrocyte membrane proteins that anchor the cytoskeleton to the plasma membrane

Question 3

direct antiglobulin test looks for

Answer 3

warm acquired autoimmune hemolytic anemia

hemolytic anemia + spherocytes on peripheral smear

Question 4

ADAMTS13 activity test looks for

Answer 4

microangiopathic hemolytic anemia

hemolytic anemia + schistocytes on peripheral smear

Question 5

What is the next step in management for a patient with new hormone receptor–positive, human epidermal growth factor 2–negative breast cancer?

Answer 5

Multigene recurrence assay

tests probability of reccurence –> low risk, just needs hormone tx, high risk needs hormone tx + chemo

Question 6

next test in patient with anemia after CBC

Answer 6

reticulocyte count and peripheral blood smear

• then iron studies

Question 7

For patients receiving highly emetogenic (causing n/v, like cisplatin) chemotherapy, the combination of ______ are guideline recommended.

Answer 7

serotonin antagonists (zofran)
neurokinin-1 receptor antagonists
glucocorticoids
olanzapine

Question 8

Diagnosis?

Answer 8

CML

Question 9

treatment of pure red cell aplasia 2/2 parvovirus in immunocompromised patient

Answer 9

IVIG

Question 10

normocytic anemia
decreased reticulocytes
giant proerythroblasts
intranuclear viral inclusions

Answer 10

pure red cell aplasia 2/2 to parvovirus B19 infection

Question 11

what breast cancer prevention drugs can you use in patients with previous DVT?

Answer 11

aromatase inhibitors (exemestane and anastrozole)

Question 12

low mean corpuscular volume
elevated red cell distribution width
peripheral blood smear showing microcytosis and anisopoikilocytosis

Diagnosis?

Answer 12

Iron deficiency anemia

If all present, do not have to order ferritin

Question 13

diarrhea in a patient on immunotherapy

dx?

tx?

Answer 13

immunotherapy-induced colitis

high dose IV steroids (methylprednisolone)