Mitosis Flashcards
Check point
controlled by a gate keeper genes which act like guards and require a signal to go to the next phase
Cyclin
family of proteins that control cells through cell cycle like kineases
maturation promoting factors
- start mitosis by dissolving the nuclear membrane
- condense chromatin
- begin spindle fiber formation
- degrade cyclin
Gaps
G1- allows cell to go to synthesis
G2-regulates passage into mitosis ensures proper DNA replication
G0-no signal where they do not replicate
Survivan
produced to allow cell to survive, without these proteins cell can go into apoptosis
cohesion
act of sticking together to form a whole
differentiated
specialized cell growth- normal somatic cells
contact inhibition
cells know when to stop growing when the size has been filled
Hayflick Limit
telomeres shorten with each nuclear division limiting the number of possible DNA replications
telomerase
prevents the shortening of telomeres
cellular adhesion molecules
CAMS allow binding with other cells or with the extracellular matrix
metastasize
cells break off and go everywhere because no cams so they break off to other organs
progeria, progerin
rapid aging due to errors due to defects in DNA repair mechanisms bc of high level of protein progerin
-autosomal
Werner Syndrome
rapid aging which causes premature death after midlife and this is autosomal recessive
Achondroplasic Dwarfism
mutation of resistant fibroblast growth factor receptors in long bone cells growth stunts mitosis
dominant
