Mitochondria

Question 1

Why did the Eykarote eat the bacteria to create a mitochondria?

Answer 1

Traditional thought is for the ATP production. WRONG

They initially kept the bacteria to prevent oxidative damage due to high O2 in cell. ATP usage developed later.

Question 2

True or false: The mitochondrial has its own DNA that encodes for all of the necessary proteins for it to function.

Answer 2

FALSE:

Mitochondrial DNA carries about 10%

Question 3

GIP is a protein on the outer membrane of the mitochondria. What kind of transport does it do?

Answer 3

Facilitated Diffusion

Question 4

How does a protein denature when it passes through TIM23/22 on the intermitochondrial membrane during transport to the matrix?

Answer 4

mtHsp70 binds to the N-terminus of the protein on the matrix side. Then using ATP it “pulls” the protein through little by little.

*think of hand over hand motion on a rope. The hands are mtHsp70s.

Question 5

Which mitochondrial protein is necessary for apoptosis?

Answer 5

Cytochrome C

Question 6

What are the levels of mitochondrial quality control

Answer 6

Molecular QC- detect if oxidative proteins are defective ( mAAA mIII)

Organellar QC- fusion/fission. Attempts to dilute bad enzymes. ALSO mitophagy-Degrade mitochondria

Cellular=apoptosis

Question 7

What are the fusion proteins for mitochondria?

Answer 7

OPA1 and Mfn

Your grandpa always brings muffins to the get together

Question 8

What are the fission proteins for mitochondria?

Answer 8

Fiz and Drp

So your fizzy drink drips away from you.

Question 9

What protein is defective in CMT (charcot-marrie-tooth)?

Answer 9

Need teeth to eat your Mfn

Question 10

What protein is defective in optic atrophy?

Answer 10

OPA (optic atrophy=op-a)