Cilia Flashcards
What are the functions of cilia?
Sensation and Motility
How many protofilaments make up a microtubule?
13
A doublet of microtubule surrounded by a ring of micro tubules makes________
A cilia.
A triplet of microtubule makes________
Basal Body
How do cilia form?
mother centriole is put into a ciliary vesicle. The vesicle does membrane fusion and creates a cilia.
What are the physical functions of cilia?
Creates a polarized localized signal and cell.
Also involved in sensing fluid flow and fluid mechanics.
What does Hedgehog do?
Limb formation, bone growth and neurogenesis
What makes left right body symmetry?
Cilia beat in a rotary motion that creates unidirectional current that carries transcription factors and signals.
How does ciliopathy contribute to PKD?
Defective cilia lead to defective Ca++ signaling and to cystogenesis.
What are the components of a cilia?
- Basal Bodies
- Axoneme
- Transition Zone
- Ciliary Membrane
What are Basal Bodies?
Cilia anchors
What is an axoneme?
Skeleton of the cilium. Formed by Doublets of microtubules.
What is the function of the transition zone of a cilia?
Limit diffusion of proteins into and out of cilium.
Sight of many ciliopathies.
When does centriole duplication occur?
G1-S
What kind of microtubule arrangement do motile cilia have?
9+2.
2 central microtubules surrounded by 9.
