Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Hematopathology > Miscellaneous II > Flashcards

Miscellaneous II Flashcards

1
Q

CD4:CD8 ratio

A

BM not good sample for this- rather PB is optimal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Causes of dyserythropoiesis

A

NK/T cell neoplasm
LGL neoplasm
Aplastic anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Hypocellular MDS

A

Should see increased blasts (otherwise, don’t flat out call it!)
Could be an evolving aplastic anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Monoblasts by flow

A

Show decreased expression of CD14 and CD36 (also CD64)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

AML from MDS morphology

A

Often see a less packed marrow than de novo AML- still see background erythroid islands

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Burkitt lymphoma in HIV

A

Can look plasmacytoid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Vacuoles in Burkitt

A

Fat- oil red O positive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Vacuoles in Erythroleukemia

A

Glycogen- PAS positive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

c-MYC threshold IHC

A

50-70%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Look for Parvovirus when you see…

A

Anemia and erythroid hypoplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Percent dysplasia to call

A

at least 10%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Hematogones in MDS

A

decreased

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

MDS comment:

A

These findings (dyserythropoiesis) are non-specific, and may be seen in:

  • nutritional deficiency
  • meds
  • infection
  • autoimmune
  • low grade MDS
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Percent hypersegmented PMNs to call

A

Greater or equal to 6%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Granulocytic finding in Folate/B12 deficiency

A

giant band

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Assessing marrow cellularity

A

Better to do on a bad core than on a good clot section (clot section compresses fat and falsely increased cellularity)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Left-shifted erythroids vs lymphoblasts

A

left-shifted erythroids= more cytoplasm

lymphoblasts= less cytoplasm

18
Q

MPN with lots of mature neutrophils, lacking myelocyte bulge

A

Consider PMF, atypical CML, and CNL

19
Q

Cat-scratch lymphadenitis

A

Stellate microabscess formation

if inguinal LN, cannot distinguish from lymphogranuloma venereum

20
Q

Plasma cell neoplasm oral cavity

A

ALWAYS remember to order HHV8 and EBER

21
Q

NLPHL architecture

A

If see PTGC but no effacement- Do NOT call NLPHL (without effacement)

22
Q

Marrow s/p rituxin

A

can see T cells in the marrow (see Foucar paper)

23
Q

Increased CD8 T cells

A

Can see in reactive conditions too (throws off CD4:CD8)

24
Q

Burkitt

A
  • paucity of small lymphs
  • “jigsaw” appearance
  • DDx: ALL, blastic mantle cell, myeloid sarc
25
Q

Lymph node with histiocytes and/or granulomas

A

Aside from the usual AFB/GMS, consider also doing a PAS to look for Whipple’s disease (PAS+)

26
Q

Amyloidoma

A

AKA nodular amyloid:

  • asymptomatic elderly with nodule on chest xray w/o evidence of systemic disease
  • good prognosis, dont often progress to lymphoproliferative disorders
  • well circumscribed amyloid, often with T lymphocytes and plasma cells
  • granulomatous reaction to amyloid common, often calcification and ossification
27
Q

Nodular LP HL

A

LP cells are positive for BCL6, EMA, OCT2, BOB1; negative for CD15 and CD30 (BUT you can see CD30 positive large cells that are reactive immunoblasts unrelated to LP cells

28
Q

Percent IHC positivity for Hans algorithm

A

30%

29
Q

“Tumor Stage MF”

A

Even in the presence of an atypical T cell proliferation with loss of CD7 and CD5, you cannot call MF. This could still be REACTIVE! Need hx of MF to call MF/lymphoma.

30
Q

IHC for MCL

A

Should do both cyclin d1 and sox-11 because sox11 can also be positive in burkitt, lymphoblastic lymphoma, and blastoid variant of mcl (dont use it to distinguish these)

31
Q

Bcl2

A

Expressed in all low grade cell lymphomas- careful with nodular pattern of mcl

32
Q

FL by flow

A

Dim CD19

33
Q

FL marrow involvement

A

Almost always see by morphology. Due to paratrabecular location, the aspirate for flow may miss it, but usually the core will show.

34
Q

Buffy coat M:E

A

Can be falsely increased bc erythroids cluster together

35
Q

Disrupted cells on aspirate

A

Tend to be erythroid. Thats way you actually over estimate the M:E a little on aspirate vs core

36
Q

Weird FL

A

If FL starts expressing T cell markers like CD5, it must have either CD10 or t(14;18) to call it. Otherwise think about mantle cell or marginal zone. Also CD11c very rare in FL, more common in MZL

37
Q

Atypical CLL

A

???

38
Q

Iron stain helps you

A

Can tell erythroid precursors vs plasma cells; also helps you tell the M:E ratio better

39
Q

Very dysplastic looking mature PMNs (abnormal lobation, hypogranularity- really ugly), increased blasts and left shift on marrow

A

Can be due to GCSF- do not call high grade MDS

40
Q

Monocyte/macrophage/histiocyte associated markers

A

Lysozyme, CD14, CD68

41
Q

Hb H inclusions

A
  • seen 3 gene deletion alpha (Hb H) and may be positive in 2 gene deletion (alpha thal minor)
  • whole blood with brilliant cresyl blue causes oxidation and ppt of Hb h
  • golf ball pattern

Hematopathology (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions