Immunophenotypes Flashcards
Precursor B Lymphoblastic Leukemia/Lymphoma
DR, CD19, CD20-/+, CD34, CD10+/-, sIg-, TdT+
May co-express myeloid Ag in t(9;22)
Infants w/CD10-,CD15+ suspect 11q23
Burkitt
DR, CD19, CD20, CD22, CD10+/-, CD34-, TdT-, sIg+ (bright)
CLL/SLL
DR, CD19, CD20 (dim), CD5, CD23, CD45, CD22-, CD10-, FMC7-, CD11c+/-, CD25+/-, sIg (dim to negative)
If bright sIg+, CD20+ suspect Trisomy 12
B Prolymphocytic Leukemia
DR, CD19, CD20 (bright), CD22, CD5-, CD23-, CD10-, sIg+ (bright)
Mantle Cell Lymphoma
DR, CD19, CD20, CD5, CD22, sIg+, CD43, CD23-, CD10-
Follicular Lymphoma
DR, CD19, CD20, CD10, CD22, CD5-, CD23+/-, CD11c-, CD43-, sIg+ (bright)
20% of cases are CD10-
Marginal Zone Lymphoma
DR, CD19, CD20, CD22, CD11c, sIg+, CD43+/-, CD5-, CD23-, CD10-, CD25-, CD103-
sIgD rare
Splenic Marginal Zone Lymphoma
DR, CD19, CD20, CD22, CD11c, sIg+, CD43-, CD5-, CD23-, CD10-, CD25-
sIgD+
Lymphoplasmacytic Lymphoma
DR, CD19, CD20, CD22, sIg+, CD43+/-, CD5-, CD10-, CD23-
Hairy Cell Leukemia
DR, CD19, CD20 (bright), CD22, CD25, sIg+, CD11c (bright), CD103, CD5-, CD10-, CD23-
Plasma Cell Myeloma
CD45, CD38 (bright), cIg+, sIg+/-, DR-, CD19-, CD20-, CD22-
CD56 often
Precursor T Lymphoblastic Leukemia/Lymphoma
cCD3, CD4, CD8, TdT, CD10-/+
May co-express multiple myeloid Ag
T Prolymphocytic Leukemia
CD2, CD3, CD5, CD7, CD4+/-, CD8-/+
Dual CD4+/CD8+ or CD4-/CD8+ rare
MF/SS
CD2, CD3, CD5, CD4, CD7-/+, CD8-, CD25-
May have no aberrant phenotype
Adult T-Cell Leukemia/Lymphoma
CD2, CD3, CD5, CD4, DR, CD25 (bright), CD7-, CD8-
