MISC - Prelims Quiz Flashcards
The functional group present in the antifungal drug Clotrimazole
a. Triazole
b. Imidazole
c. Tetrazole
d. Thiazole
b. Imidazole
Another name for methylbenzene
a. Anisole
b. Aniline
c. Toluene
d. Styrene
c. Toluene
Name of a cresol in a 1,4 position
a. n-cresol
b. p-cresol
c. m- cresol
d. o-cresol
b. p-cresol
Which of the following is a halide?
a. CH3OCH3
b. CH3OH
c. CH3SH
d. CH3F
d. CH3F
General formula for esters
a. R-OH
b. R-O-R’
c. R-COOR’
d. R-COOH
c. R-COOR’
Which of the following is a purine?
a. Thymine
b. Uracil
c. Cytosine
d. Guanine
d. Guanine
Common name for methanal
a. Formaldehyde
b. Prionaldehyde
c. Butyl aldehyde
d. Acetaldehyde
a. Formaldehyde
Azido group
a. N-=N+=N-
b. -N=O
c. -NH-NH-
d. -N=N-
a. N-=N+=N-
Which of the following is a monocarboxylic acid?
a. Malonic acid
b. Acetic acid
c. Oxalic acid
d. Succinic acid
b. Acetic acid
An ortho-disubstituted benzene has its two substituents in a __________ relationship
a. 1,5
b. 1,3
c. 1,4
d. 1,2
d. 1,2
Which heterocyclic compound contains a 6-membered ring?
a. Azepine
b. Oxirane
c. Thiazole
d. Pyridine
d. Pyridine
Common name for para-dihydroxybenzene
a. Hydroquinone
b. Resorcinol
c. Catechol
d. Cresol
a. Hydroquinone
NH3
a. Primary amine
b. Secondary amine
c. Tertiary amine
d. Ammonia
d. Ammonia
IUPAC name for acetone
a. Butanone
b. Pentanone
c. Propanone
d. Hexanone
c. Propanone
Phenformin contains what functional group?
a. Guanidino
b. Carbamate
c. Sulfonamide
d. Urea
a. Guanidino
Cofactor for sulfation
a. UDPGA
b. Acetyl-CoA
c. PAPS
d. SAM
c. PAPS
Conjugation reaction that produces less polar metabolism
a. Acetylation
b. Sulfation
c. Glycine conjugation
d. Glucuronidation
a. Acetylation
An example of a reduction reaction
a. R-NH-NH-R -> R-N=N-R
b. R-NHOH -> R-NH2
c. R-NHOH -> R-NO
d. R-NO -> R-NO2
b. R-NHOH -> R-NH2
An example of oxidation reaction
a. CH3CH3 -> CH3CH2OH
b. CH3CHO -> CH3CH2OH
c. CH3CH2OH -> CH3CH3
d. CH3COOH -> CH3CHO
a. CH3CH3 -> CH3CH2OH
Reduction of an aldehyde produces:
a. Tertiary alcohol
b. Secondary alcohol
c. Carboxylic acid
d. Primary alcohol
d. Primary alcohol
Major pathway in adults for the metabolism of acetaminophen
a. Methylation
b. Sulfation
c. Acetylation
d. Glucuronidation
d. Glucuronidation
Reduction involves
a. Removal of hydrogen atoms
b. Gain of electrons
c. Addition of oxygen atom
d. All of the above
b. Gain of electrons
Rapid acetylators include:
a. Egyptians
b. Filipinos
c. Caucasians
d. African-Americans
b. Filipinos
Major biotransformation pathway for drugs containing an ester and amide functional group
a. Hydrolysis
b. Reduction
c. Oxidation
d. Methylation
a. Hydrolysis
Major conjugation pathway in cats
a. Acetylation
b. Glucuronidation
c. Methylation
d. Sulfation
d. Sulfation
Factors that can affect drug metabolism
a. Genetic factors
b. Age differences
c. Species differences
d. All of the above
d. All of the above
__________ drugs are more readily excreted in urine
a. Lipid soluble
b. Nonpolar
c. Unionized
d. Water soluble
d. Water soluble
Cofactor for glucuronidation
a. Gly
b. GSH
c. UDPGA
c. UDPGA
Oxidation of a secondary alcohol produces a/an:
a. Ketone
b. Carboxylic acid
c. Aldehyde
d. Alkane
a. Ketone
Results from the inability of infants to conjugate bilirubin with glucuronic acid
a. Kernicterus
b. Grey baby syndrome
c. Neonatal hyperbilirubinemia
d. Two of the above
d. Two of the above
The R-isomer of ibuprofen is responsible for its anti-inflammatory activity
a. True
b. False
b. False (S-ibuprofen is responsible for anti-inflammatory activity)
Levorphanol has antitussive activity while dextrorphan has analgesic activity
a. True
b. False
b. False (Levorphanol=analgesic; Dextrorphan=antitussive)
The physicochemical properties of a drug molecule are dependent not only on what functional groups are present in the molecule but also on the spatial arrangement of those functional groups
a. True
b. False
a. True
Not all possible enantiomers of a drug are pharmacologically active
a. True
b. False
a. True
The term product stereoselectivity is used to denote a preference for one stereoisomer as a substrate for a metabolizing enzyme or metabolic process
a. True
b. False
b. False (Substrate stereoselectivity)
When two substituents of higher priority are on the same sign of the double bond, this isomer is given the designation of trans or E
a. True
b. False
b. False (cis/Z)
Most sugars found in nature are dextrorotatory while most amino acids found in nature are levorotatory
a. True
b. False
a. True
Dextroamphetamine, Dextromethorphan, and Dexlansporazole are examples of drugs that rotate the plane of polarized light to the left
a. True
b. False
b. False (To the right)
A racemic mixture is optically inactive
a. True
b. False
a. True
Esomeprazole is the S-enantiomer of Omeprazole and Armodafinil is the R-enantiomer of Modafinil
a. True
b. False
a. True
