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Boards - Oc Pharm > Misc. Oc Pharm Drugs > Flashcards

Misc. Oc Pharm Drugs Flashcards

1
Q

Anti-VEGF agents: MOA

A

Inhibit actions of VEGF: blocks vascular permeability and new blood vessel formation

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1
Q

Anti-VEGF agents (4)

A

Pegaptanib
Ranibizumab (Lucentis)
Bevacizumab (Avastin)
Aflibercept (Eylea)

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2
Q

Anti-VEGF agents: Indications (4)

A

CNVM, macular edema due to RVOs and diabetes, proliferative retinopathy, and NVG

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3
Q

Which Anti VEGF agent has a longer DOA and can stretch doses?

A

Aflibercept (Eylea)

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4
Q

Vitreolytic Agent

A

Ocriplasmin (Jetrea)

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5
Q

Vitreolytic Agent: Indication

A

ERM, VMT

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6
Q

Hyperosmotic Agents (3)

A

Glycerine
Mannitol
Sodium Chloride (Muro 128)

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7
Q

Hyperosmotic Agents: MOA

A

Unable to cross BAB: creates an osmotic gradient in which the plasma in the ciliary stroma is hypertonic compared to the aqueous, which lowers IOP

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8
Q

Hyperosmotic Agents: Indications (3)

A

lowering IOP in acute glaucoma, Reduce corneal edema (Fuch’s)
decrease risk of corneal erosions

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9
Q

GLYCERINE

  1. Indications
  2. Side effects/Contraindications
A
  1. Lower IOP in acute angle closure
  2. Increases blood sugar levels
    CI: DIABETICS

*Use Isosorbide instead

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10
Q

MANNITOL

  1. Indications
  2. SEs/Contraindications
A
  1. lower IOP in acute glaucoma
  2. Very potent, only used in hospital settings
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11
Q

Sodium Chloride (Muro 128)

  1. Indications
  2. SEs/Contraindications
A
  1. Fuch’s dystrophy with corneal edema (Endo count <500)
  2. CI: Dellen (dehydrated stroma)
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12
Q

Artificial Tears: Cyclosporine (Restasis) and Lifitegrast (Xiidra)

  1. MOA
  2. Indications
  3. SEs/Contraindications
A
  1. inhibits T cell activation by stopping production of Interleukin-2: decreased inflammation within the lacrimal gland
  2. Dry eye disease
  3. Burning, dysgeusia, decreased vision
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13
Q

Preservatives: BAK

A

Very common, can cause corneal toxicity
Increases drug penetration

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14
Q

Preservatives: Thimerosal

A

Rarely used
Preservative used in trifluridine (Viroptic)
Causes toxicity after 3 weeks of use

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15
Q

Preservatives: EDTA

A

Chelating agent that sequesters calcium.
Used for visually significant band keratopathy

16
Q

Common symptoms from preservatives (2)

A

Diffuse SPK
Conjunctival follicles

Boards - Oc Pharm (7 decks)

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