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Boards - Oc Pharm > Glaucoma Drugs > Flashcards

Glaucoma Drugs Flashcards

1
Q

Pilocarpine:

  1. Decrease aqueous production
  2. Increase uveoscleral outflow
  3. Increase cornealscleral outflow?
A
  1. Increase corneoscleral outflow
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2
Q

Brimonidine/Apraclonidine:

  1. Decrease aqueous production
  2. Increase uveoscleral outflow
  3. Increase cornealscleral outflow?
A
  1. Decrease aqueous production
  2. Increase uveoscleral outflow
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3
Q

Beta Blockers:

  1. Decrease aqueous production
  2. Increase uveoscleral outflow
  3. Increase cornealscleral outflow?
A
  1. Decrease aqueous production
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4
Q

CAIs:

  1. Decrease aqueous production
  2. Increase uveoscleral outflow
  3. Increase cornealscleral outflow?
A
  1. Decrease aqueous production
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5
Q

Prostaglandins:

  1. Decrease aqueous production
  2. Increase uveoscleral outflow
  3. Increase cornealscleral outflow?
A
  1. Increase uveoscleral outflow
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6
Q

Latanoprostene bunod (Vyzulta):

  1. Decrease aqueous production
  2. Increase uveoscleral outflow
  3. Increase cornealscleral outflow?
A
  1. Increase uveoscleral outflow
  2. Increase cornealscleral outflow
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7
Q

Rho kinase inhibitors (Rhopressa):

  1. Decrease aqueous production
  2. Increase uveoscleral outflow
  3. Increase cornealscleral outflow?
A
  1. Decrease aqueous production
  2. Increase cornealscleral outflow
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8
Q

CAIs

A

Acetazolamide/Methazolamide
Dorzolamide
Brinzolamide
Simbrinza (Brimonidine + Brinzolamide)

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9
Q

CAI: MOA

A

Blocks carbonic anhydrase which aids in increasing aqueous production

Bicarbonate increasing Na and Cl flux in the posterior chamber(CB)

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10
Q

CAI: contraindications

A

Sulfa allergies

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11
Q

CAI: Side effects

A

burning upon instillation, metallic taste

safe for asthma and COPD

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12
Q

CAI: Oral Acetazolamide (Diamox)

  1. Drug type
  2. Indications
  3. MOA
  4. SEs and contraindications
A
  1. CAI
  2. Acute glaucoma (angle closure)
  3. CAI
  4. APLASTIC ANEMIA, metallic taste, metabolic acidosis, thrombocytopenia. myopic shift, IIH

CI: severe COPD, SULFA ALLERGY, pregnancy

*CI in severe COPD due to metabolic acidosis

combat metabolic acidosis by hyperventilating: COPD pts cant hyperventilate

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13
Q

Prostaglandin analogs

A

Latanoprost
Bimatoprost
Travoprost
Tafluprost (PF)
Latanoprostene bunod

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14
Q

Prostaglandin analogs: MOA

A

Acts of FP receptors on ciliary muscle which cause reduction of neighboring collagen, decreasing resistance w/in the uveoscleral meshwork

Activates phospholipase c which alters hair follicles

Bedtime dosing

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15
Q

Prostaglandin analogs: CIs

A

Pts at risk for CME
Cases of active inflammation (uveitis, HSK)

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16
Q

Prostaglandin analogs: SEs

A

Iris heterochromia, eyelash growth, skin darkening around eyes, sunken in appearance of eyes, hyperemia

17
Q

How to find target IOP

A

Tmax x .3
TP = Value above - Tmax

18
Q

Latanoprostene bunod

  1. Drug type
  2. Indications
  3. MOA
A
  1. Prostaglandin analog
  2. Glaucoma
  3. Acts on uveoscleral pathway to increase outflow: release NO which increases outflow through the TM pathway
19
Q

Rho Kinase Inhibitor drug

A

Netarsadil (Rhopressa)
Rocklatan (netarsadil + latanoprost)

20
Q

Rho Kinase Inhibitor: MOA

A
  1. Inhibits rho kinase, which increases smooth musccle contraction w/in the TM
  2. Antifibrotic - reverses functional damage in the TM
  3. Vasodilation: reduces episcleral venous pressure
  4. Inhibits norepinephrine transporter w/in CB, which decreases aqueous production

Dosed QHS

21
Q

Rho Kinase Inhibitor: SEs

A

Hyperemia, Subconj. hemes, whorl keratopathy

Boards - Oc Pharm (7 decks)

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