Autonomic Drugs - Intro

Question 1

2 Parasympathetic Receptors

Answer 1

Muscarinic, Nicotinic

Question 2

Sympathetic cell bodies location

Answer 2

Thoraco-lumbar region

Question 3

Parasympathetic cell bodies location

Answer 3

Cranio sacral

Question 4

Parasympathetic pathway

Answer 4

Cell Bodies —> (Ach) CB —> (ach) SOA @ M3

Question 5

Sympathetic pathway

Answer 5

Cell bodies—> (Ach) CB —> epi/norepi SOA (b1, b2, a1, a2)

Question 6

Parasympathetic actions (4)

Answer 6

SLUD
salavation, lacrimation, urination, defecation

Question 7

Cholinergic Receptors in the eye (3)

Answer 7

Iris sphincter (M3) ciliary muscle (M2, M3) lacrimal gland (M2, M3)

Question 8

Adrenergic receptors in the eye (5)

Answer 8

Iris dilator (a1), TM (b2), ciliary muscle (b2), NPCE (b1, b2-active secretion), CB vessels(MACI) (a2)

Question 9

MOA - Cholinergic agonists

Answer 9

Increases ACh by decreasing Ache

Question 10

MOA - Cholinergic antagonists

Answer 10

Blocks ACh

Question 11

MOA - Adrenergic agonists

Answer 11

Target a1 and a2 receptors - released epinephrine @ SOA

Question 12

MOA - Adrenergic antagonists

Answer 12

Blocks beta receptors

Question 13

What happens at each of the following receptors?
1. Iris sphincter (M3)
2. Ciliary muscle (M2, M3)
3. Lacrimal gland (M2, M3)

Answer 13

1. Miosis
2. Accommodation
3. Increased tear production

Question 14

What happens at each of the following receptors?
1. Iris dilator (a1)
2. TM (b2)
3. Ciliary muscle (b2)
4. NPCE (b1, b2)
5. CB vasculature (a2)

Answer 14

1. Dilation
2. Relaxation/ increased outflow
3. Relaxation, opposes accommodation
4. Increases aqueous formation (active secretion)
5. Constricts, reduces aqueous formation