Anti-Inflammatory Agents

Question 1

Anti-Inflammatory drugs

Answer 1

Potent corticosteroids:
Pred. acetate 1%
Difluprednate (Durezol)
Dexamethasone

Soft steroids:
FML
Loteprednol
Pred. acetate 0.125%

NSAIDs:
Diclofenac
Ketorolac
Nepafenac
Bromfenac
Flurbiprofen

Question 2

What are the following drug combos?

Zylet
Maxitrol
Tobradex

Answer 2

Zylet (Tobramycin + loteprednol)
Maxitrol (
Tobradex (tobramycin + dexamethasone)

Question 3

Anti-Inflammatory: Corticosteroid MOA

Answer 3

Inhibits phospholipase A2 –> inhibits arachidonic acid pathway, decreases inflammatory mediators and capillary permeability
decreases immune response

Question 4

Anti-Inflammatory: Potent steroid indications

Answer 4

Uveitis

Question 5

Anti-Inflammatory: Soft steroid indications

Answer 5

Dry eye
Allergic conjunctivitis
Episcleritis
Thygeson’s

Question 6

Steroids: SEs

Answer 6

PSC
Increased IOP due to increased GAGs in TM
Increased risk of secondary infections
Delayed wound healing
Increased risk of glaucoma

Question 7

NSAIDs: MOA

Answer 7

Block COX I and COX II which inhibits conversion of arachidonic acid into prostaglandins and thromboxanes

Question 8

NSAIDs: Indications

Answer 8

Post-op cataract patients to decrease risk of CME, RCES, abrasions, etc.

Question 9

NSAIDs: SE

Answer 9

Corneal toxicity
Corneal melting
Stinging

Question 10

Only NSAID approved for topical tx of allergic conjunctivitis?

Answer 10

Ketorolac