MISC 01 - Problem Set

Question 1

Ringer’s solution contains 0.33 g of calcium chloride per L. Express the concentration in terms of mEq of calcium chloride per liter. MW=147

Answer 1

4.49 mEq/L

Question 2

A 40-mL vial of a sodium chloride was diluted to a liter with sterile water. The concentration (w/v) of NaCl (MW 58.5) in the finished product was 0.58%. What was the concentration in mEq per mL of the original solution?

Answer 2

2.48 mEq/mL

Question 3

Ammonium chloride (MW 53.5) is to be used as a urinary acidifier with a dose of 150 mEq. How many 500-mg tablets should be administered?

Answer 3

16 tablets

Question 4

A physician wishes to administer 1,200,000 units of penicillin G potassium every 4 hours. If 1 unit of
penG potassium (MW 372) is 0.6 microgram, how many mEq of potassium will the patient receive in
a 24-hour period?

Answer 4

11.61 mEq

Question 5

A patient is to receive 10 mEq of potassium gluconate (MW 234) four times a day for 3 days. If the
dose is to be a teaspoonful of syrup vehicle. How many grams of potassium gluconate should be
used and what volume in mL should be dispensed to provide the prescribed dosage regimen?

Answer 5

28.08 g, 60 mL

Question 6

A person is to receive 36 mg of ammonium chloride per kg of body weight. If the person weighs 154
lb, how many mL of sterile solution of ammonium chloride containing 0.4 mEq should be administered? MW 53.5

Answer 6

117.76 mL

Question 7

A solution containing 5% dextrose in water injection. How many milliosmoles/L are represented in this concentration? MW 180.

Answer 7

277.78 mOsmol/L

Question 8

A solution contains 156 mg of potassium ions in 100 mL. How many mOsmol are represented per L of the solution? AW=39.

Answer 8

40 mOsmol/L

Question 9

A ringer’s solution contain 0.33g of calcium chloride per L. How many milliosmols of calcium are
represented in each liter of the solutions? MW = 147g

Answer 9

6.73 mOsmol/L

Question 10

How many milliosmoles of NaCl are represented in 1L of 3% hypertonic NaCl solution? Assume complete dissociation. MW 58.5

Answer 10

1025.64 mOsmol/L

Question 11

The solubility of sulfamethoxypyridazine (SMP) in a 10% by volume mixture of dioxane and 90% by volume of water is 1.8 mg/mL at 25°C.

Calculate:
a. molarity
b. molality
c. mole fraction of SMP.

The density of the liquid, dioxane, is 1.0313 g/mL, of the solution 1.0086 g/mL, of water 0.9970 g/mL,
and of the solvent mixture 1.0082 g/mL. The molecular weight of SMP is 280.32 g/mole, that of dioxane is 88.10, and that of water is 18.015.

Answer 11

a. 0.0064 M
b. 0.0064 m
c. 0.00013

Question 12

How much sodium chloride is required to render 100mL of a 1% solution of apomorphine hydrochloride isotonic with blood serum? It is found that a 1% solution of the drug has a freezing point lowering of 0.08°C. How will you prepare the solution?

Answer 12

0.76% w/v NaCl

Question 13

Calculate the approximate E value for a new amphetamine hydrochloride derivative (MW 187; L iso value 3.4).

Answer 13

0.31

Question 14

Calculate the approximate E value for a new amphetamine hydrochloride derivative (MW 187; L iso value 3.4).

Based from this previous problem, a solution contains 1.0 g apomorphine hydrochloride in a volume of 100 mL. What quantity of sodium chloride must be added to make the solution isotonic? If one desired to use dextrose instead of sodium chloride, how much dextrose would be required for this purpose?

Answer 14

0.59 g NaCl, 3.28 g Dextrose

Question 15

Prepare 200 mL of an isotonic aqueous solution of thimerosal (MW 404.84; L iso 3.4). The concentration of this antiinfective drug is 1:5000.

a. Calculate the E value.
b. Adjust the Isotonicity of the solution using NaCl.

Answer 15

0.14, 1.79 g NaCl

Question 16

Suppose that one wishes to make 30 mL of a 1% solution of procaine hydrochloride isotonic with body fluid. Adjust the Isotonicity using the two Class II methods. The E value of procaine hydrochloride is 0.21.

Answer 16

7 mL (White Vincent method); 2.10 mL (Sprowl’s method)

Question 17

Calculate the vapor pressure when 0.5 mole of sucrose is added to 1000 g of water at 20°C. The vapor pressure of water at 20°C is 17.54 mmHg.

Answer 17

17.38 mmHg

Question 18

A 0.200 m aqueous solution of a drug gave a boiling point elevation of 0.103°C. Calculate the approximate molal elevation constant for the solvent, water.

Answer 18

0.52 °C/m

Question 19

The freezing point of water on the scale of the Beckmann thermometer (this is an apparatus used to determine freezing point) is 1.11°C and the value for an aqueous solution of the solute is 0.120°C. What is the apparent Kf value if the concentration of the solution is 0.50 m?

Answer 19

1.98 °C/m

Question 20

One gram of sucrose, molecular weight 342, is dissolved in 100mL of solution at 25°C. What is the osmotic pressure of the solution?

Answer 20

0.72 atm