Mirtazapine (Antidepressant) Flashcards
What are the brand names of mirtazapine?
Remeron
What strength mirtazapine tablets are available?
7.5 mg, 15 mg, 30 mg, 45 mg
What strength mirtazapine ODT tablets are available?
15mg, 30 mg, 45 mg
What is the approved indication and dosage of Remeron?
- Indicated for the treatment of depression.
- The recommended starting dose is 15 mg per day given in a single dose, preferably at bedtime. Maintenance dose range is 15 to 45 mg per day. Dosage changes should occur at intervals of 1 to 2 weeks due to Remeron’s long elimination half-life.
What is the mechanism of action for mirtazapine?
The mechanism of action 0f mirtazapine may be due to its action as an antagonist of central presynaptic alpha-2 adrenergic inhibitory autoreceptors and heteroreceptors, an action that is postulated to result in an increase in noradrenergic and seretonergic activity.
What are the drug interactions of mirtazapine?
- May have additive effect with CNS depressant drugs.
- Combination with MAO inhibitor’s may result in serious and sometimes fatal reactions.
- Coadministration with aspirin or NSAIDs may increase the risk of upper G.I. bleeding
What are the contraindications of Remeron?
- Antidepressants increase suicidal thoughts and actions in children, adolescents, and young adults.
- Rare cases of agranulocytosis have occurred during treatment.
- If a patient develops a sore throat, fever, stomatitis, or other signs of infection, along with a low WBC, treatment should be discontinued and the patient monitored.
- Do not use with a mega inhibitors or within 14 days of initiating or discontinuing MAO I therapy. Patient at high risk of suicide should be supervised during initiation of therapy.
- Abrupt discontinuation of therapy may cause adverse effects including dysphoric mood, irritability, agitation, dizziness, anxiety, confusion, insomnia, and headache.
- Pregnancy category C
What are the address effects of mirtazapine?
Drowsiness, dry mouth, increased appetite, constipation, weight gain, dizziness, fleas syndromes, and abnormal dreams.
The following adverse effects have been reported in 2% or less of patients in controlled studies: back pain, peripheral edema, myalgia, tremor, confusion, dyspnea, and urinary frequency.
What should the pharmacist tell the patient when counseling them on the use of Remeron?
- Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. Antidepressants may increase suicidal thoughts or actions.
- May cause drowsiness. Use care when operating machinery or when mental alertness is required.
- Avoid alcohol while taking this medication.
- Up to two weeks maybe needed it before therapeutic effects are seen.
- Do not abruptly discontinue medication.
- Contact a physician if you develop a sore throat, fever, stomatitis, or other signs of infection.
- If a dose missed, skip it and return to normal dosing schedule.
- SoluTabs must be used immediately upon opening individual tablet blisters.