Fluoxetine Hydrochloride (Antidepressant) Flashcards
What are the brand names of fluoxetine hydrochloride?
Prozac and Sarafem
What strength tablet Prozac is available?
10 mg, 20 mg, 60 mg
What strength Prozac capsules are available?
10mg, 20 mg, 40 mg
What strength delayed release Prozac capsules are available?
90 mg
What strength Prozac liquid suspension is available?
20mg/5mL (mint flavor)
What are the FDA approved indications for fluoxetine hydrochloride?
For the treatment of depression, OCD, bulimia nervosa, panic disorder
What is the dosage of Prozac when used to treat depression?
- Start with 10 mg per day, followed by increases every two weeks until clinical improvement is seen.
- Normal daily dose is range from 10 mg to 40 mg.
- Maximum daily dose is 80 mg.
- The full anti-depressant affect may not be seen till four weeks of treatment has passed.
- After 13 weeks of treatment with third 20 mg once a day, patients maybe switched to Prozac weekly 90 mg given once a week. Prozac weekly can be initiated seven days following the last daily 20 mg dose.
What is the dose of Prozac used for the treatment of OCD?
Start with 20 mg per day, followed by increases every two weeks until clinical improvement is saying. Doses over 20 mg per day should be given to divided doses in the morning and at noon.
What is the dose of Sarafem used for the treatment of panic disorders?
Start with 10 mg per day and increase to 20 mg per day after one week. Maximum daily dose is 60 mg.
What is the dose of Prozac used for the treatment of bulimia nervosa?
60 mg per day, administered in the morning.
What is the mechanism of action of fluoxetine?
Fluoxetine blocks in your arsenal uptake of serotonin, but not ignore FNF friend, into human platelets in the CNS. SSRI
What are the drug interactions of fluoxetine hydrochloride?
- May cause serious reactions with monoamine oxidase inhibitors, wait a minimum of 14 days after stopping an MAOI before starting therapy. Wait five weeks after stopping therapy before starting an MAOI.
- May increase for a thioridazine levels. Wait five weeks after stopping therapy before starting thioridazine .
- May increase plasma levels of tricyclic antidepressants, benzodiazepines, phenytoin, carbamazepine, and drugs metabolized by cytochrome P450II6.
- Adverse effects may occur when used with tryptophan or sumatriptan.
- Coadministration with aspirin or an NSAID may increase the risk of upper G.I. bleeding.
What are the contraindications fluoxetine?
- Contraindicated in patients taking MAOI or thioridazine.
- Antidepressants increase suicidal thoughts and actions in children, adolescents, and young adults.
- A rash occurring after initiating treatment may progress to more serious cutaneous systemic illness.
- Due to the possibility of suicide attempts, caution should be taken in dispensing large quantities of this medication.
- Use with caution in patients with liver disease.
- Abrupt discontinuation of therapy may cause adverse effects including dysphoric mood, irritability, agitation, dizziness, anxiety, confusion, insomnia and headache. Not indicated for therapy in patients under the age of seven years
- Pregnancy Category B
What are the address effects of fluoxetine?
Most common adverse effects include nausea, insomnia, anorexia, headache, nervousness, drowsiness, tremor, diarrhea, sweating, asthenia, decreased libido, abnormal ejaculation and fatigue.
What should the pharmacist tell the patient when counseling them on the use of Prozac?
- Pay close attention to any changes, especially sudden changes, in mood behaviors, thoughts, or feelings. Antidepressants my increased suicidal thoughts or actions.
- May cause drowsiness.
- Use caution while operating machinery or when mental alertness is required.
- Avoid alcohol while taking this medication.
- Up to two weeks may be needed before therapeutic affect her saying.
- Do not abruptly discontinue medication.
- Notify physician if rash or hives develop
- if a dose is missed, skip it and return to normal dosing schedule.
