Bupropion Hydrochloride (Antidepressant)

Question 1

What are the brand names of bupropion hydrochloride

Answer 1

Wellbutrin, Forfivo XL, Zyban

Question 2

What immediate release tablet strengths are available for bupropion hydrochloride?

Answer 2

75 mg and 100 mg

Question 3

What sustained release tablet doses are available for buproprion hydrochloride?

Answer 3

100 mg, 150 mg, 200 mg

Question 4

What extended release tablet doses are available for bupropion hydrochloride?

Answer 4

150 mg, 300 mg, 450 mg

Question 5

What sustained release tablet doses are available under the name Zyban?

Answer 5

150 mg

Question 6

What is the FTA approved indication and dosage of bupropion hydrochloride?

Answer 6

Treatment of depression for the prevention of seasonal major depressive episodes in patients with seasonal affective disorder.

Immediate-release formulation: Start with 100 mg twice a day. Increase a dose of maximum of 100 mg per day no sooner than every three days to achieve maximum benefit. You sure daughter is 100 mg three times a day. Maximum daily dose is 450 mg per day. No single day should exceed 150 mg. He’s the lowest dose possible to achieve desired results.

Sustained-release formulation: Give up to 400 mg per day in two divided doses. Target dose is 300 mg per day.

Extended-release formulation: 150 to 300 mg given once per day

Question 7

What dose of pion Hydro chloride is used as an aid for smoking cessation?

Answer 7

Zyban is used as an aid to smoking cessation. Start with 150 mg daily for three days then increased to 150 mg twice a day.

Question 8

What is the mechanism of action of bupropion hydrochloride?

Answer 8

It is a week inhibitor of neuron uptake of norepinephrine and dopamine. And does not inhibit monoamine oxidase

Question 9

What are the drug interactions of bupropion hydrochloride?

Answer 9

• Toxicity is increased by monoamine oxidase inhibitor’s an L-Dopa.
• Bupropion may lower seizure threshold.
• Drugs which affect the CYP2B6 isoenzyme system may affect the propane plasma levels.
• Ritonavir and lopinavir reduce the plasma levels of bupropion.
• Bupropion is an inhibitor of CYP2D6 therefore it may increase plasma levels of tricyclic antidepressants, paroxetine, fluoxetine, sertraline, haloperidol, risperidone, thioridazine, metoprolol, propafenone, or flecanide

Question 10

What are the contraindications of bupropion hydrochloride?

Answer 10

• Contraindicated in patients with a seizure disorder, history of bulimia or anorexia nervosa, or within 14 days of therapy with a monoamine oxidase inhibitor.
• Antidepressants increase suicidal thoughts and actions and children, adolescents, and young adults.
• Wellbutrin has been associated with precipitating dose-related seizures. Seizure incidence increases tenfold between daily doses of 450 mg and 600 mg.
• May cause various psycho motor disturbances such as mania, psychosis, and hallucinations.
• Use with caution in patients with impaired liver or kidney function.
• Pregnancy Category C

Question 11

What are the adverse effects of bupropion hydrochloride?

Answer 11

Dizziness, constipation, weight loss, dry mouth, insomnia, sweating, agitation, and tremor.

Question 12

What should a RPh tell the patient when counseling them on the use of bupropion hydrochloride?

Answer 12

• Take at immediate release tablets at regular intervals no sooner than 3 to 4 times a day.
• Take extended release tablets in the morning if possible to avoid insomnia.
  Swallow SR and XL tablets whole, do not crush or chew.
• If a dose is missed, wait until the next scheduled dose do not double taxes.
• Do not take OTC medication w/o first consulting a physician or pharmacist.
• Refrain from consuming alcohol.
• Weight loss or gain may be temporary contact your physician bothersome.
• Pay close attention to any changes, especially sudden changes, and move behaviors, thoughts, or feelings. Antidepressants may increase suicidal thoughts or actions.
• Continued therapy of up to two weeks maybe need to show noticeable improvement